UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2018 » Volume 26, issue 2 (95) » The peculiarities of metabolic changes in patients in recovery and residual periods of aneurysmal subarachnoid haemorrhage

The peculiarities of metabolic changes in patients in recovery and residual periods of aneurysmal subarachnoid haemorrhage

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Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 612.015.39: 576.311.347-02:616.831-005.1-036.6

Abstract

The aim of this study was to explore the indicators of apoptosis, necrosis, mitochondrial dysfunction and oxidative stress in patients in early and late recovery and residual periods of aneurysmal subarachnoid haemorrhage (aSAH). We examined 82 patients, divided them into groups according to age, sex, catamnesis, hemorrhage form, aneurysm localization and surgical treatment method. By the method of fl ow cytofl uorometry we defi ned the elevation of white blood cells (WBC) in apoptosis and necrosis — by 2,88 and 1,96 times. The level of WBC with reduced mitochondrial membrane potential increased by 2,17 and the level of reactive oxygen species (ROS) was higher by 2,82 times. The statistically reliable diff erence was absent in patients of different age and hemorrhage form. But in groups which were divided due to sex, catamnesis, aneurysm localization and surgical treatment method we received statistically reliable results. Significantly higher indicators of apoptosis were observed in the female group. Mythochondrial dysfunction was higher in recovery period. Patients, who underwent endovascular surgery method showed higher level of ROS than those who had not any surgical treatment. Those who had vertebrobasilar localization of aneurysm showed signifi cantly higher apoptosis level

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  • 19-21

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References

  1. Grasso G., Alafaci C., Macdonald R. L. Management of aneurysmal subarachnoid hemorrhage: State of the art and future perspectives  // Surgical Neurology International. 2017; 8: 11. doi: 10.4103/2152-7806.198738.
  2. Risk of rupture of an intracranial aneurysm based on patient characteristics: a case-control study  / [Vlak    H., Rinkel  G.  J., Greebe P., Algra A.] // Stroke. 2013. Т. 44. No. 5. С. 1256—1259.
  3. Aronowski J., Hall C. E. New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies // Neurol Res. 2005; 27: 268—79.
  4. Intracranial Hemorrhage — Mechanisms of Secondary Brain Injury / Lok J., Leung W., Murphy S. [et al.] // Acta Neurochirurgica Supplement. 2011; 111: 63—69.
  5. Qu , Chen W., Hu  R., Feng H. The  Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria // Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, Article ID 2592935. doi:https://doi.org/10.1155/2016/2592935.
  6. Oxidative stress in the human brain after subarachnoid hemorrhage / Gaetani P., Pasqualin A., Baena R. [et al.] // J Neurosurg. 1998; 89: 748—754.
  7. Cerebrospinal fluid superoxide dismutase and serum malondialdehyde levels in patients with aneurysmal subarachnoid hemorrhage: preliminary results / Kaynar M. Y., Tanriverdi T., Kemerdere R. [et al.] // Neurol Res. 2005; 27: 562—567.
  8. Antioxidant status and alpha1-antiproteinase activity in subarachnoid hemorrhage patients / Marzatico F., Gaetani P., Tartara F. [et al.] // Life Sci. 1998;63:821—826.
  9. Globa M. V., Moroz V. V., Veksler V. V. Features of cerebral vasospasm in ruptured arterial aneurysms of the vertebral-basilar basin // Proceedings of the IV Congress of Neurosurgeons of Ukraine, Dnipropetrovsk, May 27–30, 2008. P. 175. Dnipropetrovsk, May 27-30, 2008. P. 175.
  10. Features of intracranial hemorrhages from ruptured arteriovenous malformations / [L. A. Dzyak, K. V. Mitrofanov, E. V. Mizyakina, E. S. Tsurkalenko] // Pathology. 2009. Vol. 6, No. 3. Pp. 40–48.
  11. Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage / Hasegawa Y., Suzuki  , Sozen T. [et al.]. In: Early Brain Injury or Cerebral Vasospasm / Feng H., Mao Y., Zhang J.  H. (eds)  // Acta Neurochirurgica Supplements. 2011. Vol. 110/1. P. 43—8.
  12. Matz P. G., Copin J. C., Chan P. H. Cell death after exposure to subarachnoid hemolysate correlates inversely with expression of CuZn-superoxide dismutase // Stroke. 2000; 31: 2450—1.
  13. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage / Park S., Yamaguchi M., Zhou C. [et al.] // Ibid. 2004; 35: 2412—4.
  14. Prunell F., Svendgaard N.-A., Alkass  K., & Mathiesen T. Delayed cell death related to  acute cerebral blood flow changes following subarachnoid hemorrhage in  the rat brain  // Journal of Neurosurgery. 2005. 102(6), 1046—1054. https://doi.org/10.3171/jns.2005.102.6.1046.
  15. Sehba, F. A., Pluta, R. M., & Zhang, J. Metamorphosis of Subarachnoid Hemorrhage Research: from Delayed Vasospasm to Early Brain Injury // Molecular Neurobiology. 2011. 43 (1), 27—40. URL : https://doi.org/10.1007/s12035-010-8155-z.
  16. Interference of apoptosis in the pathophysiology of subarachnoid hemorrhage / Palade C., Ciurea A. V., Nica D. A. [et al.] // Asian Journal of Neurosurgery. 2013; 8(2): 106—111. doi:https://doi.org/10.4103/1793-5482.116389.
  17. Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis / Nieuwkamp D. J., Setz L. E., Algra A. [et al.] // The Lancet Neurology. 2009. Т. 8. No. 7. С. 635—642.

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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