The clinical-psychopathological features of nonpsychotic mental disorders (NMD) in patients with rheumatoid arthritis (RA) depending on the duration of the disease are described in the article. On the basis of a comprehensive clinical psychopathological study data were obtained on the structure of NMD in RA: in the main group with a total duration of rheumatoid arthritis up to 5 years (MG I) in comparison with the main group with duration of rheumatoid arthritis from 5 to 10 years (MG II), were predominantly disorders of adaptation on 11.9 %: 27.3 % in MG I and 15.4 % in MG IІ (p < 0.05); somatoform disorder was more often diagnosed with an advantage of 11.3 % with 23.6 % in MG I and 12.3 % in MG II (p < 0.04); anxious-phobic disorder was dominated by 15.4 %: 20.0 % in MG I and 4.6 % in MG II (p < 0.006), and in the MG II, compared with the MG I, the mixed anxiety-depressive disorder was more often diagnosed with an advantage of 34.2 %, namely 61.5 % and 27.3 % (p < 0.0001). On the measure of the development of RA, the general indexes of the level of depression increased from 9,16 points to 10.84 point(p < 0.05) and general indexes of the level of anxiety — from 11,10 points to 13,12 point (p < 0.05). The system of diagnostic of NMD in patients with RA has been scientifi cally substantiated, developed and implemented, as a result of the conducted clinical and psychopathological research.