As a result of the study of cognitive functions in patients with alcohol dependence with diff erent treatment regimens and practically healthy persons (control group СG), it was elucidated that before treatment cognitive disorders in patients of both groups were manifested by a violation of regulatory functions, a low level of attention resistance was revealed in comparison with СG; psychopathological manifestations were more represented in the group of patients who received additional metabolic and neuroprotective therapy (group ІІ). After treatment, the positive dynamics of cognitive performance was determined by the increased level of sour memory and forgiving of the received information in patients receiving detoxifi cation therapy; among patients of group II, there was an increase in the speed of the tests of all scales. Therapeutic tactics chosen for both groups of patients significantly reduced the manifestations of psychopathological symptoms in the early stages of the treatment process.