UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325

Concept of minimal cerebral dysfunction genesis and possible approaches for it prevention

Type of Article

In the Section

Index UDK:

Abstract

Complex investigation of 106 children (72 boys and 34 girls) with diff erent clinical variants of minimal cerebral dysfunction (MCD), from 5 to 10 years of age has been done. Attention defi - cit with hyperactivity syndrome was revealed in 74 patients

t was approved that the main etiologic factors of MCD are early (anteperinatal) CNS lesions, which cause abnormal maturation of certain cerebral structures, and which are presented in more or less severe way at diff erent developmental stages in 74.53 ± 4.25 % of children.

Rationality and effi cacy of neurometabolic therapy in children with MCD have been shown due to positive clinical and electroencephalographic dynamics.

Concept of MCD genesis and prevention of it development has been worked out.

Pages

References

  1. Martyniuk V.Y., Zinchenko S.M. Minimal cerebral dysfunction: a textbook. Kyiv: Intermed, 2011. 168 с.
  2. Zavadenko, N. N. Hyperactivity and attention deficit in childhood. Moscow, 2005. 256 с.
  3. Morozova E. A., Morozov D. V. Perinatal pathology of the central nervous system in the genesis of the development of attention deficit hyperactivity disorder and its treatment // Journal of Neurology and Psychiatry. С. С. Korsakov. 2008. Т. 108, № 2. С. 70-72.
  4. Faraone, S. V., Mick Molecular genetics of  attention deficit hyperactivity disorder  // Psychiatr Clin North Am  Mar. 2010. № 33(1). P. 159—180.
  5. Gizer, I. R., Ficks C., Waldman I. Candidate gene studies of  ADHD: a  meta-analytic review  // Hum  Genet. 2009. №  126. P. 51—90.
  6. Sharp, S. I., McQuillin A., Gurling H. M. Genetics of attentiondeficit hyperactivity disorder (ADHD) // Neuropharmacology. 2009. № 57. P. 590—600.
  7. Lou, H. C. Etiology and pathogenesis of ADHD: significance of prematurity and perinatal hypoxic-haemodinamic encephalopathy // Acta Paediatr. 1996; 85: 1266—71.
  8. Domitrak, S. V. Minimal brain dysfunction (risk factors, clinical, neurophysiological and neuropsychophysiological aspects, treatment) : author's thesis for the degree of Candidate of Medical Sciences. Irkutsk, 2012. 20 с.
  9. ADHD: increased dopamine receptor availability linked to attention deficit and low neonatal cerebral blood flow / H.   Lou, P. Rosa, O. Pryds [et al.] // Acta Paediatr. 1996; 85: 1266—71.
  10. Nigg, G. What causes ADHD? New  York  ; London  : The Guilford Press, 2006; 422.
  11. Diagnostic and Statistical Manual of Mental Disorders (4th edition Revision) (DSM-IV-TR). American Psychiatric Association. Washington, DC, 2000; 943.