In people with post-traumatic stress disorder (PTSD), dependence on psychoactive substances appears 2—3 times more often than without it. Alcohol intake, which subjectively causes a feeling of reduced anxiety and flashbacks, temporarily increases Gamma-aminobutyric acid, the amygdala (fear center) becomes hyperactive, and the prefrontal cortex, which is responsible for control and rational thinking, begins to work worse and reduces arousal. A conditioned reflex alcohol = relief is formed, which leads to increased doses of alcohol and forms dependence in a patient with PTSD. A vicious circle is created: PTSD exacerbates alcoholism, alcoholism exacerbates PTSD. This circle can be broken with the right, comprehensive approach, taking into account a special approach to the diagnosis and treatment of a patient with a comorbid pathology. In the study, adaptability in patients with comorbid (combined) post-traumatic stress disorder (PTSD) and alcohol dependence is critically reduced

The purpose of the study — determining the general level of adaptability and quality of life in patients with combined pathology (PTSD + alcohol use disorders).

According to literary sources, the data were obtained using the “Adaptivnist-200” questionnaire and quality of life assessment scale according to Mezzich et al.

It was found that integral indicators of quality of life were the worst in conditions of isolated PTSD (9.35 ± 0.50) and combined with alcohol use disorders (7.76 ± 0.75) compared to the comparison and control groups (p > 0.05 with comparison group and p < 0.05 with control group). Patients with PTSD (main groups: MG1 and MG2) rated their performance of social roles the worst (19.94 and 12.00; pMG1 — MG2 < 0.05 vs. 10.00 points in comparison group; pMG1 — CompG 0.05). The best quality of life for combatants with PTSD combined with alcohol use disorders was observed in interpersonal interaction (4.53 points), and in conditions of isolated PTSD — in self-care and independence of action (3.88 points).