Post-stress mental disorders caused by military operations in the east of Ukraine are becoming one of the most important internal barriers during adaptation to peaceful life. Due to the accumulation of new stresses associated with social maladaptation on this substrate. We conducted a comprehensive survey of 299 patients with non-psychotic mental disorders, both sexes (mean age — 30.6 ± 4.7 years). The first study group consisted of 96 servicemen of the Armed Forces of Ukraine who were directly involved in hostilities in the Joint Forces Operation zone (66 men and 30 women); group II — 98 volunteers whose activities are related to the support of the soldiers in the Joint Forces Operation zone (44 men and 54 women); group III — 105 internally displaced persons (52 men and 53 women). The clinical structure of post-stress disorders in the examined patients was presented by: posttraumatic stress disorder (F43.1); adjustment disorders (prolonged anxietydepressive reaction) (F43.21); anxiety disorders: generalized anxiety disorder (F41.1); panic disorder (F41.0). The data obtained during the study formed basis for the development of a comprehensive personalized program for the correction of non-psychotic mental disorders and rehabilitation of combat stress victims with the differentiated use of psychopharmacotherapy, psychotherapy and psychoeducation.