203 patients were examined, including 75 with dementia at Alzheimer’s disease (AD), 73 with vascular dementia (VD) and 60 patients with mixed dementia (MD). Patients were divided into main and control group by the factor of presence/absence of signs of suicidal behavior (intentions, attempts, thoughts, anti-vital mood, statements). Among patients with AD, 36 patients were the main group, 39 were the control group; at VD 39 patients were main group, 34 were control group; in mixed dementia, 30 patients were included in the main group, 30 patients were in the control group.

It has been found that in 56 % of cases with dementia due to Alzheimer’s disease, in 65 % with vascular dementia and 56 % with mixed dementia of the clinical picture, suicidal behavior (SB) is observed.

The complex of factors of SB risk/anti-risk and suicide-genesis mechanisms in dementia, that became the targets for development of differentiated program for medical and psychological rehabilitation and prevention (MPRP) patients with SB in dementia were distinguished.

The suicide-genesis concept in dementia which determines the mechanisms of the formation of suicidal behavior under the influence of clinical and intra-personal indexes, was worked out.

Accounting the formation mechanisms and SB predictors, special features of clinical and psychopathological, clinical and phenomenological SB demonstration in various types of dementia the complex and differentiated MPRP program and SB prevention, realized on the basis of complex approach including usage of psychopharmacological, psychotherapeutic, psychoeducational psychosocial actions was worked out and tested.

The result of the developed system testing proved its high efficiency, which is supported by the positive dynamics of clinical and psychopathological indexes of suicide status and level of independence in the everyday life of patients with SB in dementia.