The article presents the features of the structure of heredity factors and their influence on the clinical and psychopathological image of recurrent depression. The study involved 87 patients with recurrent depression. Based on the results of socio-demographic, clinical-genealogical, clinical-psychopathological, psychometric studies, a high level of family related depression factors were established at all stages and levels of relationship in the genealogy of patients with recurrent depressive disorders. It is shown that in the proband genealogy, there is a high percentage of observed patients mainly of the 1st degree of relationship, by a psychiatrist. Among the inherited burden of somatic pathology in the genealogy of patients with recurrent depressive disorders, hypertension, heart disease and endocrine pathology prevail. When analyzing the information obtained, it was determined that the proportion of factors such as observation by a psychiatrist for the 1st and 2nd degrees of relationship, depressive disorders mainly for 2nd degree of relationship, suicidal behavior for the 1st and 2nd degrees of relationship and the predominance of recurrent disorder in the clinical picture of hypochondriacal and apathetic syndromes, affects the course and clinical picture of recurrent depression. The information received should be considered as diagnostic and preventive measures in the provision of care for this category of patients