In order to determine the psychological characteristics of the personality of patients with epilepsy and comorbidity depressions, were analised of characterological features, personality characteristics defining socio-psychological adaptation, forms of manifestation of aggressiveness in patients with organic, psychogenic and endogenous depressions in the interictal period of epilepsy. It has been established that patients with epilepsy and depression are characterized by the anadaptive nature of personal organization: persistent pessimism, decreased contact tendencies, rigidity of affective reactions, propensity to develop and accumulate hostile reactions with insuffi cient active realization of aggressive tendencies. The results of the study should be taken into account as targets in psychotherapeutic and psychoprophylactic work with patients with epilepsy.