UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2019 » Volume 27, issue 3 (100) » The role of single nucleotide polymorphism Val66Met in BDNF gene in the formation of end points after ST segment elevation myocardial infarction

The role of single nucleotide polymorphism Val66Met in BDNF gene in the formation of end points after ST segment elevation myocardial infarction

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Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

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Index UDK:
  • 616.127-005.8-092:575.113.2-021.25

Abstract

The purpose of this study was to research the possible associations of single-nucleotide polymorphism of Val66Met BDNF gene with the occurrence of endpoints after 6 months of follow-up after a myocardial infarction with ST elevation segment — ST segment elevation myocardial infarction (STEMI). To participate in the study, 256 patients which met all the inclusion criteria were hospitalized in the department of intensive care, State Institution “L. T. Malaya Therapy National Institute NAMSU” from January 2016 to February 2019. Blood fl ow to all patients was restored at the level TIMI III. The frequency of genotypes Val66Met gene for BDNF in STEMI patients (n = 256) was the following: 66ValVal — 74.2 % (n = 190), 66ValMet + 66MetMet — 25.8 % (n = 66). The study of single-nucleotide polymorphism of Val66Met gene BDNF (rs6265) was performed by real-time polymerase chain reaction using the “TacMan TMSNP Genotyping Assays” production of Thermo Fisher Scientifi c Assay IDC_11592758_1. The emotional state of the patients and its relationship with stress were assessed with the questionnaire “Depression, Anxiety and Stress Scale-21”. It turned out that the 66ValMet + 66MetMet polymorphism of the BDNF gene, stress and anxiety 10—14 days before the event, as well as reduced left ventricular ejection fraction, are associated with an unfavorable prognosis of the combined end point 6 months after STEMI and are its independent predictors.

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  • 19-25

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References

  1. Depression and coronary heart disease: 2018 ESC position paper of the working group of  coronary pathophysiology and microcirculation developed under the auspices of  the ESC Committee for Practice Guidelines  / Vaccarino V., Badimon L., Bremner J. D. [et al.] ; ESC Scientific Document Group Reviewers // European Heart Journal, 2018. 28. DOI: https://doi.org/10.1093/eurheartj/ehy913.
  2. Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes / Manni L., Nikolova V., Vyagova D. [et al.] // Int J Cardiol. 2005. Vol. 102(1), No. 22. P. 169—171. DOI: https://doi.org/10.1016/j.ijcard.2004.10.041.
  3. Jiang H., Liu Y., Zhang Y., Chen Z. Y. Association of plasma brain-derived neurotrophic factor and cardiovascular risk factors and prognosis in angina pectoris  // Biochem Biophys Res Commun. 2011. Vol. 415(1), No. 11. P. 99—103. DOI: https://doi.org/10.1016/j.bbrc.2011.10.020.
  4. Skaper S. D. The neurotrophin family of neurotrophic factors: an overview // Methods Mol Biol. 2012. Vol. 846. P. 1—12. DOI: https://doi.org/10.1007/978-1-61779-536-7_1.
  5. The role of neurotrophins in psychopathology and cardiovascular diseases: psychosomatic connections / László A., Lénárt L., Illésy [et  al.]  // J  Neural Transm (Vienna).  2019 Vol.  126(3). P. 265—278. DOI: https://doi.org/10.1007/s00702-019-01973-6.
  6. Emanueli C., Meloni M., Hasan W., Habecker B. A. The biology of neurotrophins: cardiovascular function // Handb Exp Pharmacol. 2014. Vol. 220. P. 309—328. DOI: https://doi.org/10.1007/978-3-642-45106-5_12.
  7. Kermani P., Hempstead B. Brain-derived neurotrophic factor: a newly described mediator of  angiogenesis  // Trends Cardiovasc Med. 2007. Vol. 17, Issue 4. P. 140—143. DOI: https://doi.org/10.1016/j.tcm.2007.03.002.
  8. Physical training and hypertension have opposite effects on endothelial brain-derived neurotrophic factor expression  / Prigent-Tessier A., Quirié A., Maguin-Gaté K. [et al.] // Cardiovascular Research, 2013. Vol. 100(3), No. 1. P. 374—382. URL: https://doi.org/10.1093/cvr/cvt219.
  9. Brain derived neurotrophic factor is an  endothelial cell survival factor required for intramyocardial vessel stabilization / Donovan M. J., Lin M. I., Wiegn P. [et al.] // Development. 2000. Vol. 127(21). P. 4531—4540.
  10. Brain-derived neurotrophic factor gene polymorphisms are associated with coronary artery disease-related depression and antidepressant response / Liu Y. Q. Su G. B., Duan C. H. [et al.] // Mol Med 2014. Vol.  10(6). P.  3247—3253. DOI: https://doi.org/10.3892/mmr.2014.2638.  PMID: 11023857.
  11. The BDNF val66met polymorphism affects activitydependent secretion of BDNF and human memory and hippocampal function / Egan M. F., Kojima M., Callicott J. H. [et al.] // Cell. 2003. Vol. 112(2), No. 24. P. 257—269. DOI: https://doi.org/10.1016/s0092-8674(03)00035-7.
  12. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) / Ibanez B., James S., Agewall S. [et al.] ; ESC Scientific Document Group // Eur Heart J. 2018. Vol. 39(2). P. 119—177 DOI: https://doi.org/10.1093/eurheartj/ehx393.
  13. 2016 ESC/EAS Guidelines for the Management of Dyslipidemias / Catapano A. , Graham I., De  Backer G. [et  al.]  ; ESC Scientific Document Group // Eur Heart J. 2016 Oct 14; Vol. 37(39): 2999—3058. URL : https://doi.org/10.1093/eurheartj/ehw272.
  14. 2018 ESC/ESH Guidelines for the management of arterial hypertension / Williams , Mancia  G., Spiering W. [et  al.]  ; ESC Scientific Document Group  // Eur  Heart J. 2018. Vol. 39 (33). P. 3021—3104. DOI: https://doi.org/10.1093/eurheartj/ehy339.
  15. 2016 ESC guidelines f or the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC / Ponikowski P., Voors A. A., Anker S. D. [et al.] ; ESC Scientifi c Document Group // Eur J Heart Fail. 2016. Vol. 18. P. 891—975. DOI: https://doi.org/10.1093/eurheartj/ehw128.
  16. Caporali A., Emanueli C. Cardiovascular actions of neurotrophins // Physiol Rev. 2009 Jan; 89(1): 279—308. DOI: https://doi.org/10.1152/physrev.00007.2008.
  17. Taşçı İ., Kabul H. K., Aydoğdu A. Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases // Anadolu Kardiyol Derg. 2012. Vol. 12(8). P. 684—688. DOI: https://doi.org/10.5152/akd.2012.221.
  18. Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort / Jiang R., Babyak M. A., Brummett H. [et  al.]  // Am  Heart J. 2017. Vol.  190. P.  40—45. DOI: https://doi.org/10.1016/j.ahj.2017.05.002.
  19. BDNF expression of macrophages and angiogenesis after myocardial infarction / Hong J.  , Park H.  M., Byun K.  H. [et al.] // Int J Cardiol. 2014. Vol. 176(3), No. 20. P. 1405—1408. DOI: https://doi.org/10.1016/j.ijcard.2014.08.019.
  20. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation / Feng N., Huke S., Zhu [et  al.]  // Proc Natl Acad Sci  U  S  A. 2015. Vol.  112(6), No.  10. P. 1880—1885. DOI: https://doi.org/10.1073/pnas.1417949112.
  21. Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway / Okada S., Yokoyama M., Toko H. [et al.] // Arterioscler Thromb Vasc Biol. 2012. Vol. 32(8). P. 1902—1909. DOI: https://doi.org/10.1161/ATVBAHA.112.248930.
  22. Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice  / Halade G. V., Ma Y., Ramirez T.  [et  al.]  // Am J Physiol Heart Circ Physiol. 2013. Vol. 305(12). P. 1830—1842. DOI: https://doi.org/10.1152/ajpheart.00224.2013.
  23. BDNF Val66Met polymorphism is associated with unstable angina / Jiang H., Wang R., Liu Y. [et al.] // Clin Chim Acta. 2009. Vol. 400(1—2). P. 3—7. DOI: https://doi.org/10.1016/j.cca.2008.10.017.
  24. Coronary artery disease and depression: possible role of brainderived neurotrophic factor and serotonin transporter gene polymorphisms / Bozzini S., Gambelli P., Boiocchi C. [et al.] // Int J Mol Med. 2009. Vol. 24(6). P. 813—818. DOI: https://doi.org/10.3892/ijmm_00000297.
  25. BDNF Val66Met polymorphism, life stress and depression: A meta-analysis of gene-environment interaction  / Zhao  , Chen L., Yang J. [et al.] // J Affect Disord. 2018. Vol. 227. P. 226—235. DOI: https://doi.org/10.1016/j.jad.2017.10.024.
  26. BDNFVal66met polymorphism: a potential bridge between depression and thrombosis / Amadio P., Colombo G. I., Tarantino E. [et al.] // Eur Heart J. 2017. Vol. 38(18), No. 7. P. 1426—1435. DOI: https://doi.org/10.1093/eurheartj/ehv655.
  27. Exploring the association between BDNF Val66Met polymorphism and suicidal behavior: Meta-analysis and systematic review / González-Castro T. B., Salas-Magaña M., Juárez-Rojop I. E. [et al.] //. J Psychiatr Res. 2017. Vol. 94. P. 208—217. DOI: https://doi.org/10.1016/j.jpsychires.2017.07.020.
  28. Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients / Aldoghachi A. F., Tor   S., Redzun S.  Z. [et  al.]  // PLoS ONE. 2019. Vol.  14(1). e0211241. URL: https://doi.org/10.1371/journal.pone.0211241.
  29. BDNF val66met polymorphism and depressive disorders in patients with acute coronary syndrome / Kang  , Bae  K. Y., Kim S. W. [et al.] // J Affect Disord. 2016. Vol. 194. P. 1—8. DOI: https://doi.org/10.1016/j.jad.2016.01.033.
  30. The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress / Alexander N., Osinsky R., Schmitz A. [et al.] // Psychoneuroendocrinology. 2010. Vol. 35(6). P. 949—953. DOI: https://doi.org/10.1016/j.psyneuen.2009.12.008.

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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