The paper presents the results of a comprehensive study of the characteristics of the psychopathological state of patients with epilepsy and depressions of various genesis (organic, psychogenic and endogenous) in the interi ctal period. Were investigated the severity and structure of psychopathological manifestations, as well as separately the level and structure of anxiety in patients with epilepsy depending on the form of depression in a comparative aspect with patients with epilepsy without signs of depression. According to the selected forms of depression, are analyzed the severity and structural features of depressive symptoms. Was established that patients with depressions are characterized by more pronounced and diverse psychopathological manifestations, in the structure of which, apart from depressive manifestations, anxious and psychosomatic symptoms are formed (with organic and psychogenic depressions); as well as asthenic manifestations, a decrease in the level of interpersonal interaction and obsessive-compulsive symptoms (with endogenous depressions). Is determined the highest level of psychopathological distress in patients with epilepsy with endogenous depressions.