UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2019 » Volume 27, issue 2 (99) » Dysfunction of bloodbrain barrier and intrathecal immune response in patients with clinically isolated multiple sclerosis syndrome

Dysfunction of bloodbrain barrier and intrathecal immune response in patients with clinically isolated multiple sclerosis syndrome

Authors

Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 616.831-009.81

Abstract

The study is devoted to the evaluation of blood-brain barrier dysfunction and intrathecal synthesis of immunoglobulin G in patients with clinically isolated syndrome (CIS) of multiple sclerosis. The presence of oligoclonal bands and immunoglobulin G indicates an increased risk of multiple sclerosis in patients with CIS, regardless of the presence of other risk factors. An observational study of an intranasal response in patients with CIS was performed for the fi rst time in Ukraine. Based on the evaluation of cerebrospinal fl uid and blood parameters in 19 adult patients, it was found that 68 % of patients had an impairment of permeability of the blood-brain barrier. Synthesis of intrathecal immunoglobulin G is present in two thirds of cases.

Pages

  • 20-22

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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