The article presents the results of a comprehensive clinical and psychopathological study of the characteristics of clinical manifestations, the perception of mental and somatic diseases, as well as the features of social and personal functioning and quality of life of patients with schizophrenia with obesity, which served as the basis for developing strategic areas of therapy for patients of this group. Were highlighted the strategic direction of treatment of patients with obesity and schizophrenia: holding antipsychotic therapy, taking into account the presence of obesity, mastering the skills of controlling food intake and lifestyle correction; development of skills to control stress and own psychopathological state, as well as increase social competence and social and personal functioning of patients.