UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2013 » Volume 21, issue 4 (77) » THE POPULATION AND GENETIC ANALYSIS OF FORMATION OF ADDICTIVE STATES AND ESTIMATION OF POSSIBILITIES FOR COUNTERACTION TO THEIR PROLIFERATION

THE POPULATION AND GENETIC ANALYSIS OF FORMATION OF ADDICTIVE STATES AND ESTIMATION OF POSSIBILITIES FOR COUNTERACTION TO THEIR PROLIFERATION

Authors

Type of Article

  • Scientific Article

In the Section

  • PROBLEMATIC ARTICLES

Key words

Index UDK:
  • 616.89-008.441.13-036.22

Abstract

The aim of the study is estimation of possibilities for counteraction to proliferation of addictive states by complex analysis of dynamics of epidemiological data, and also balance genetic and environmental determinants in formation of narcological profi le disorders among representatives of diff erent generations of inhabitants of Ukraine. It is analyzed the offi cial medical statistics concerning dynamics of the registered prevalence of addictive states caused by use of psychoactive substances (PAS) for 1954—2012. 447 patients with addictive states of diff erent origin are surveyed, including: 181 alcohol depended persons; 60 opiate depended persons; 23 psychostimulants depended persons and 183 persons with others (including combined) dependences, and also 2735 members of their families (the relatives of І and ІІ relationship degrees). The analysis phenotypic dispersions on the basis of presence of addictive states caused by use PAS (or prenosological abusings of PAS) with defi nition of specifi c weight of genetic and environmental determinant of formation of the specifi ed conditions is carried out. It is established, that diff erent generations of citizens of Ukraine (potential users of PAS) during last decades lived in conditions with essentially diff ering levels of prevalence of addictive states. Accumulation of cases of tobacco smoking and drunkenness in families of the surveyed patients is revealed. It is shown, that the balance environmental and genetic determinant of formation of conditions of dependence is variable value in time. It is proved, that during life of last three generations of inhabitants of Ukraine specifi c weight of environmental component of this balance has essentially grown, and genetic has decreased. The conclusion that these changes are caused by environment saturation with various PAS, and also their advertising is drawn. Thereof even those people who have no essential genetic predisposition to pathological addiction get to it now. It is off ered to consider current specifi c weight of environmental component as an indicator of theoretically achievable level of effi ciency of actions for counteractions to addictive states, and the indicator of practically achievable level is the lowest value of this component for all period of time accessible to supervision

Pages

  • 5-11

Year / Issue

Download PDF

References

  1. Minko, A. I. Narcology [Text] / A. I. Minko, I. V. Linsky / 2nd edition, revised and supplemented. - M. : EXMO Publishing House, 2004. - 736 с.
  2. Frances, R. J. Clinical Textbook of Addictive Disorders [Text] / R. J. Frances, S. I. Miller, A. H. Mack A. H. — Guilford Press, 2011. — 684 p.
  3. Galanter, M. The American Psychiatric Publishing Textbook of Substance Abuse Treatment [Text] / M. Galanter, H. D. Kleber. — American Psychiatric Pub., 2008. — 752 p.
  4. Guzikov, B. M. Addictive behavior of adolescents as a path to drug addiction, substance abuse and early alcoholism [Text] / B. M. Guzikov // Review of psychiatry and medical psychology named after V. M. Bekhterev. V. M. Bekhterev. - 1991. - № 2. - С. 116-118.
  5. Liskovsky, Y. V. Genetic risk of alcoholism development [Text] / Y. V. Liskovsky. In: Alcohol intoxication and dependence: mechanism of development, diagnostics, treatment. - Minsk : Belarus, 1988. - С. 148-153.
  6. Epidemics of alcoholism and drug and substance abuse in the mirror of medical statistics of the Ministry of Health of Ukraine [Text]: Analytical and statistical handbook 1990-2008 / P.V. Voloshin, M.V. Golubchikov, I.V. Linsky, O.I. Minko [et al: "Pleyada, 2009. 168 p.
  7. Mental and behavioral disorders due to alcohol and other psychoactive substances in Ukraine. The state of drug treatment for the population of Ukraine [Text]: Informational and analytical review for 1990-2010 / M.K. Khobzey, O.M. Kolyakova, O.M. Zinchenko [et al: "Pleyada, 2011. 138 p.
  8. Indicators of population health and use of health care resources in Ukraine for 2011: a collection of the Ministry of Health. [Electronic resource]. - Access mode: http://medstat.gov.ua/ukr/main.htm
  9. Indicators of population health and use of health care resources in Ukraine for 2011: a collection of the Ministry of Health. [Electronic resource]. - Access mode: http://medstat.gov.ua/ukr/main.html
  10. AUDIT — The Alcohol Use Disorders Identification Test. Guidelines for Use in Primary Care. Second Edition [Text] / T. F. Babor, J. C. Higgins-Biddle, J. B. Saunders [et al.] — World Health Organization. Department of Mental Health and Substance Dependence, 2001.
  11. Linskij I. V., Minko A. I., Artemchuk A. F. i dr. Metod kompleksnoj ocenki addiktivnogo statusa individa i populyacii s pomoshh’yu sistemy’ AUDIT-podobny’x testov. Vіsnik psixіatrії ta psixofarmakoterapії. 2009. No. 2 (16). S. 56—70.
  12. Faulconer, D. S. Introduction to the genetics of quantitative traits [Text] / D. S. Faulconer. - Moscow: Agropromizdat, 1985. - 486 с.
  13. Atramentova, L. A. Introduction to psychogenetics [Text] : textbook / L. A. Atramentova, O. V. Filiptsova. - Moscow: Flinta: MSPI, 2008. - 472 с.
  14. Atramentova, L. A. Genes and behavior [Text] / L. A. Atramentova, O. V. Filiptsova. - Kharkov : "Likhtar"; "Sovremennaya Printa", 2008. - 496 с.
  15. Lapach S. N., Chubenko A. V., Babich P. N. Statisticheskie metody' v mediko-biologicheskih issledovaniyah s ispol'zovaniem Excel. Kiev : Morіon, 2000. 320 s.
  16. Linskiy I.V., Minko A.I., Artemchuk A.F. i dr. Addiktivnyy status i metod yego kompleksnoy otsenki pri pomoshchi sistemy AUDIT-podobnykh testov [Addictive status and a method for its comprehensive assessment using a system of AUDIT-like tests]. Psikhicheskoye zdorovye [Mental health]. 2010. No. 6. S. 33—45. (In Ukrainian).

Journal’s Indexing:

UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

ДУ «ІНПН імені
П.В. ВОЛОШИНА
НАМН УКРАЇНИ»