The purpose of the work is to explore the features of the relationship between the severity of psychosocial disadaptation and aff ective symptoms in women with depressive disorders of diff erent genesis, in order to further defi ne the highly specifi c targets of differentiated psychosocial rehabilitation for this contingent of patients.

252 women who were diagnosed with depressive disorder were examined: 94 persons with depressive disorder of psychogenic origin (F43.21), 83 women with endogenous depression (F32.0, F32.1, F32.2, F32.3, F33.0, F33.1, F33.2, F33.3, F31.3, F31.4, F31.5) and 75 patients with depressive disorder of organic genesis (F06.3).

To identify and measure the severity of psychosocial disadaptation, we have developed an original scale for a comprehensive assessment of the degree of psychosocial maladaptation in various spheres. The features of the manifestation of affective symptoms were determined according to the scale of depression and anxiety M. Hamilton.

The severity of psychosocial disadaptation was the lowest in the psychogenic nature of depression, the more severe in the endogenous and the most severe — in the organic genesis.

The degree of psychosocial maladaptation in patients with depressive disorders reveals obvious associations with the severity of aff ective symptoms. At the same time, such associations are not absolute, and for some forms of depression and certain spheres of psychosocial maladaptation are not statistically signifi cant. This testifi es to more complex mechanisms of psychosocial disadaptation in depressive disorders, and the need to study other factors that may have an eff ect on the state of disadaptation, in addition to the severity of aff ective symptoms.