UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325

Cognitive impairments in patients with bipolar aff ective disorder (clinical features, diagnosis, therapy

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In the Section

Index UDK:

Abstract

It was performed an examination of 120 patients with bipolar affective disorder (BAD), including 40 patients (33.3 %) with predomination of depressive symptoms (F31.3—5, F31.6) (BAD-D), 30 patients (25.0 %) with predomination of maniacal symptoms (F31.0—2, F31.6) (BAD-M), and 50 patients (41.7 %) in euthymic period (F31.7) (BAD-E).

It was determined that cognitive impairments in BAD were manifested as a wide range of psychopathological phenomena which were more prevalent in patients with BAD-M and BAD-D and were less prevalent in patients with BAD-E. Peculiarities of the BAD phenomenological structure for diff erent phases of the disease were detected. Patients with BAD-M had such manifestations of cognitive impairments as a increased selfesteem (56.7 %) and speed of thoughts (86.7 %), an exaggeration of their achievements and abilities (73.3 %), impairments of executive functions, fi rst of all, in problems with a decision making (83.3 %).

In patients with BAD-D cognitive impairments were registered as rigidity of thinking (52.5 %), impairments with concentration (95.0 %) and executive functions (planning and decision making) (85.0 %).

Peculiarities of cognitive impairments in diff erent BAD phases were important criteria for diagnosis of this pathology and should be taken into account in therapeutic processes and rehabilitation of such patients. A consideration of characteristics of cognitive functioning depending on BAD phase allows improving effi cacy of treatment for this category of patients.

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References

  1. Aleksandrov, A. A. Bipolar affective disorder: diagnosis, clinic, course of the disease [Text] / A. A. Aleksandrov // Medical News. - 2007. - №12. - C. 7-12.
  2. Kozhina, A.M. Modern strategies in the treatment of bipolar affective disorder [Text] / A.M. Kozhina, L.M. Gaychuk // Psycheskoe zdorovye [Mental health] - 2009. - T. 3-4 (24-25). - P. 60-62.
  3. Maruta, N. A. Bipolar disorders: prevalence, medical and social consequences, diagnostic problems [Electronic resource] / N. A. Maruta // Neuro News. - 2011. - No. 2 (29). - Mode of access : http://www.neuro.health-ua.com/article/439.html.
  4. Ocheretyana, N. Bipolar disorder: clinical review [Text] / N. Ocheretyana // Zdorovye Ukrainy. - 2011. - № 4 (19). - P. 36-37.
  5. Haustova, E. A. Modern aspects of diagnosis and treatment of bipolar depression [Text] / E. A. Haustova, V. G. Bezsheiko, A. P. Romaniv // Neuro - 2012. - №1(36). - С. 38-42.
  6. The state of mental health of the population and prospects for the development of psychiatric care in Ukraine [Text] / M.K. Khobzey, P.V. Voloshyn, N.O. Maruta et al.
  7. Chaban, O. S. Bipolar depression: problems of diagnosis and therapy [Text] / O. S. Chaban, E. A. Haustova // Neuro News. - 2011. - №5(32). - С. 18-22.
  8. Is unrecognized bipolar disorder a frequent contributor to apparent treatment resistant depression [Text] / R. Correa, H. Akiskal, W. Gilmer et al. // J. Affect. Disord. — 2010. — V. 127. — P. 10—18.
  9. Trotta, A. Do premorbid and post-onset cognitive functioning differ between schizophrenia and bipolar disorder? A systematic review and meta-analysis [Text] / A. Trotta, R. M. Murray, J. H. MacCabe // Psychol. Med. — 2014. — Vol. 1. — P. 1—14.
  10. A systematic review of the evidence of the burden of bipolar disorder in Europe [Electronic Resource] / L. Fajutrao, J.  Locklear, J. Priaulx, A. Heyes // Clin. Pract. Epidemiol. Ment. Health. — 2009. — Vol. 5. — P.: 3. Available at. — Mode of access : URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646705/
  11. Cognition and functioning in bipolar depression [Text] / N.    Kapczinski, J.  C. Narvaez, P. V. Magalhães et  al.  // Rev. Bras. Psiquiatr. — 2016. — Feb 5. — doi: https://doi.org/10.1590/1516-4446-2014-1558 
  12. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 [Text] / R. Lozano, M. Naghavi, K. Foreman, et al. // The Lancet. — 2013. — Т. 380. — № 9859. — Р. 2095—2128.
  13. Robinson, L. J. Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence [Text]  / L. J. Robinson, I. N. Ferrier // Bipolar Disorders. — 2006. — Vol. 8. — P. 103—116.
  14. Vieta, E. Clinical management and burden of bipolar disorder: results from a multinational longitudinal study (WAVE-bd) [Text] / E. Vieta // International Journal of Neuropsychopharmacology. — 2013. — №16. — P. 1719—1732.