Post-traumatic stress disorder (PTSD) is one of the most important stress-related psychiatric conditions among military personnel, and its co-occurrence with personality disorders worsens the disease course and prognosis. The study aimed to identify the clinical and psychopathological features of PTSD in these patients and to assess how underlying personality pathology affects disease progression and treatment outcomes.

In a prospective open-label clinical study (January 2025 — January 2026), military personnel diagnosed with and comorbid PD were examined. Personality pathology was screened using the PDQ-4+ questionnaire, and symptom severity was measured with PCL-5 (PTSD), PHQ-9 (depression), and GAD-7 (anxiety) scales. Participants received combined treatment (pharmacotherapy and psychotherapy), after which their symptom dynamics were evaluated. Cluster analysis of PTSD symptom profiles and multiple regression methods were applied to identify factors influencing treatment results.

The results showed a high initial severity of PTSD symptoms and significant anxiety levels in the cohort. Cluster analysis revealed the largest post-treatment changes in the "arousal/reactivity" symptom cluster. The findings indicate that PTSD in military personnel with personality disorders is characterized by clinically significant symptom polymorphism and variable pathodynamics, and that premorbid personality pathology affects the rate of symptom reduction during therapy. These data emphasize the need for personalized treatment approaches in line with current guidelines for managing stress-related disorders.