Post-traumatic stress disorder (PTSD) combined with mild traumatic brain injury (mTBI) is associated with persistent impairments in cognitive functioning, emotional regulation, and behavioral adaptation, significantly limiting functional recovery. Standard pharmacological treatments often demonstrate limited efficacy in this population, highlighting the need for integrated therapeutic approaches.

Objective. To evaluate the effectiveness of combining Acceptance and Commitment Therapy (ACT) with transcranial direct current stimulation (tDCS) in reducing PTSD symptoms and improving cognitive and affective functioning in patients with PTSD and blast-related mTBI.

The study included patients diagnosed with PTSD and mild traumatic brain injury. A combined intervention consisting of structured ACT sessions and a course of tDCS targeting prefrontal cortical regions was applied. Cognitive functioning, emotional regulation, and PTSD symptom severity were assessed before and after the intervention.

The combined ACT and tDCS intervention was associated with a significant reduction in PTSD symptom severity, as well as improvements in attention, executive functions, and emotional stability. The findings suggest a synergistic effect of psychotherapeutic and neuromodulatory interventions.

The integrated ACT + tDCS model represents a promising treatment approach for patients with PTSD and mTBI, contributing to improvements in cognitive and affective functioning. Further studies are needed to refine treatment protocols and assess long-term outcomes.