UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2026 » Volume 34, issue 1 (126) » EXPERIMENTAL RESEARCH OF THE EFFECT OF ANTAGOMIR-137 ANTAGONIST ON THE LEVEL OF ALCOHOL MOTIVATION UNDER CONDITIONS OF PROLONGED AD LIBITUM ACCESS TO ETHANOL SOLUTION

EXPERIMENTAL RESEARCH OF THE EFFECT OF ANTAGOMIR-137 ANTAGONIST ON THE LEVEL OF ALCOHOL MOTIVATION UNDER CONDITIONS OF PROLONGED AD LIBITUM ACCESS TO ETHANOL SOLUTION

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Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 612.825:612.8:577.21+615.9

Abstract

Using nonlinear laboratory male rats after preventive chronic ad libitum alcoholization, individual indicators of the level of ethanol preference (%) and the average daily dose of its consumption (g/kg) were studied in a 2-bottle test. It was shown that in the paradigm of continuous contact with a 15% ethanol solution and drinking water, 100%(!) of experimental animals of a random micropopulation acquired various pathological cravings, which were divided into three categories according to the intensity of ethanol consumption, such as: with low motivation — 21.43% ((4.74±0.93)%; (0.57±0.13) g/kg); those who moderately consume alcohol — 60.71% ((30.31±2.93) %; (1.43±0.21) g/kg); highly motivated — 17.86% ((60.10±5.02)%; (2.56±0.27) g/kg). Using this model under conditions of ethanol deprivation, a randomized study of the effect of the liposomal form of the AntagomiR-137 on the severity of alcohol motivation was carried out by course intranasal administration. A certain positive effect was determined in the form of a decrease in the amount of ethanol consumption against the background of actualization of its preference. It is assumed that this is due to changes in the expression of miR-137 through the use of its AntagomiR, which is its competitor, preventing complementary pairing with target genes, which can lead to pathogenetic modulation of mechanisms for correcting alcohol motivation and does not exclude the existence of its "therapeutic" potential, which may be the basis for the development of new methods of treating disorders associated with excessive use of psychoactive substances.

Pages

  • 11-17

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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