The aim of the work is a comparative analysis of the prevalence and structure of affective, somatovegetative and cognitive psychopathological reactions in patients with diffuse alopecia of various genesis.

In compliance with the principles of biomedical ethics, on the basis of informed consent, we clinically examined 153 patients with diffuse alopecia. Within the framework of its diagnosis, two groups with different etiopathogenetic mechanisms were distinguished: the metabolic form (45 people), and the mixed form (108 patients), which has a heterogeneity of etiological and number of pathogenetic factors, among which a separate stressful psychoemotional factor is distinguished.

It was established that in patients with diffuse alopecia, psychopathological reactions from all spheres of mental response are recorded — affective, cognitive and somatovegetative, however, their prevalence varies depending on the sphere and genesis of alopecia.

The highest prevalence of psychopathological symptoms is observed in cognitive functioning — impaired concentration of attention was found in 67.4 % of the examined, of which 78.7 % among people with mixed and 40.0 % — with metabolic alopecia, p > 0.05), while for sensitivity — there is a significant difference depending on the genesis of alopecia (35.2 % in people with mixed, 17.8 % with metabolic alopecia, p < 0.05).

The obtained data will become the basis for further research into the relationship between psychopathological manifestations and personal and psychosocial factors of patient functioning, the results of which will become the basis for the development of differentiated approaches to the management of patients with diffuse alopecia within the framework of a multidisciplinary biopsychosocial approach to the medical and psychological rehabilitation of this contingent.