UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2024 » Volume 32, issue 3 (120) » PULSE THERAPY WITH CORTICOSTEROIDS IN PATIENTS WITH MULTIPLE SCLEROSIS: ADVERSE EVENTS AND WAYS TO OVERCOME THEM

PULSE THERAPY WITH CORTICOSTEROIDS IN PATIENTS WITH MULTIPLE SCLEROSIS: ADVERSE EVENTS AND WAYS TO OVERCOME THEM

Authors

Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 616.832-004.12:616.8-085.2/.3

Abstract

Pulse therapy with methylprednisolone remains the standard treatment for exacerbations of multiple sclerosis (MS). The appointment of glucocorticoids can cause a number of undesirable phenomena and complications, one of which is the development of steroid myopathy and pronounced general weakness. As a way to reduce the expressiveness of these violations, «Metacartin» was used. The study included 57 patients with a reliable diagnosis of multiple sclerosis at the stage of exacerbation of the pathological process. There were 32 (56.14 %) patients with the relapsing-remitting course (RRC) of MS, and 25 (43.86 %) with the secondaryprogressive course (SPC). All patients were randomly divided into two groups: I — 33 (57.89 %) patients who underwent a course of pulse therapy with methylprednisolone followed by the introduction of «Metacartin», and II — 24 (42.11 %) patients who received only pulse therapy methylprednisolone therapy. Group I included 23 patients with RRP and 10 patients with SPC MS. 15 patients with RRC and 9 patients with SPC MS were included in the II group. The study showed the effectiveness of combination of pulse-therapy with methylprednisolone and the drug "Metacartin", the prescription of which reliably reduced the severity of "muscular" symptoms when pulse therapy was prescribed.

Pages

  • 18-25

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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