UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2024 » Volume 32, issue 1 (118) » CLINICAL SIGNIFICANCE OF IMMUNOLOGICAL INDICATORS IN THE REMOTE PERIOD AFTER TRAUMATIC BRAIN INJURY

CLINICAL SIGNIFICANCE OF IMMUNOLOGICAL INDICATORS IN THE REMOTE PERIOD AFTER TRAUMATIC BRAIN INJURY

Authors

Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 616.01/-099-:616.831-001-08

Abstract

The article describes the clinical significance of immunological indicators in the remote period after traumatic brain injury (TBI). Immunological indicators take a key role in determining the clinical outcomes in the remote period of TBI, as they reflect the state of the body’s immune reactivity and correlate with the body’s ability to recover. Changes in both humoral and cellular immunity have been observed in patients with TBI. Variations in immunological parameters can serve as predictors for assessing the rehabilitative potential of patients after TBI.

Pages

  • 19-23

Year / Issue

Download PDF

References

  1. Voss JD, Connolly J, Schwab KA, Scher AI. Update on the Epidemiology of Concussion/Mild Traumatic Brain Injury. Curr Pain Headache Rep. 2015 Jul;19(7):32. doi: https://doi.org/10.1007/s11916-015-0506-z. PMID: 26049775.
  2. LoBue C, Munro C, Schaffert J, Didehbani N, Hart J, Batjer H, Cullum CM. Traumatic Brain Injury and Risk of Long-Term Brain Changes, Accumulation of Pathological Markers, and Developing Dementia: A Review. J Alzheimers Dis. 2019;70(3):629-654. doi: https://doi.org/10.3233/JAD-190028. PMID: 31282414.
  3. Singaravelu Jaganathan K, Sullivan KA. Traumatic Brain Injury Rehabilitation: An Exercise Immunology Perspective. Exerc Immunol Rev. 2022;28:90-97. PMID: 35452396.
  4. Failla MD, Wagner AK. Models of Posttraumatic Brain Injury Neurorehabilitation. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and  Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 35. PMID: 26269917.
  5. Needham EJ, Helmy A, Zanier ER, Jones JL, Coles AJ, Menon DK. The immunological response to traumatic brain injury. J Neuroimmunol. 2019 Jul 15;332:112-125. doi: https://doi.org/10.1016/j.jneuroim.2019.04.005. Epub 2019 Apr 11. PMID: 31005712.
  6. Postolache TT, Wadhawan A, Can A, Lowry CA, Woodbury M, Makkar H, Hoisington AJ, Scott AJ, Potocki E, Benros ME, Stiller JW. Inflammation in Traumatic Brain Injury. J Alzheimers Dis. 2020;74(1):1-28. doi: https://doi.org/10.3233/JAD-191150. PMID: 32176646; PMCID: PMC8190673.
  7. Bolte AC, Dutta AB, Hurt ME, Smirnov I, Kovacs MA, McKee CA, Ennerfelt HE, Shapiro D, Nguyen BH, Frost EL, Lammert CR, Kipnis J, Lukens JR. Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. Nat Commun. 2020 Sep 10;11(1):4524. doi: https://doi.org/10.1038/s41467-020-18113-4. PMID: 32913280; PMCID: PMC7483525.
  8. Shively SB, Wannamaker BB, Willis AM, Brugge JF, Ness J. Editorial: Traumatic Brain Injury and Autoimmune Disease. Front Neurol. 2021 Jun 18;12:702431. doi: https://doi.org/10.3389/fneur.2021.702431. PMID: 34220697; PMCID: PMC8249800.
  9. Kobeissy F, Moshourab RA. Autoantibodies in CNS Trauma and Neuropsychiatric Disorders: A New Generation of Biomarkers. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 29. PMID: 26269907.
  10. VanItallie TB. Traumatic brain injury (TBI) in collision sports: Possible mechanisms of transformation into chronic traumatic encephalopathy (CTE). Metabolism. 2019 Nov;100S:153943. doi: https://doi.org/10.1016/j.metabol.2019.07.007. PMID: 31610856.
  11. Abou-Donia MB, Abou-Donia MM, ElMasry EM, Monro JA, Mulder MF. Autoantibodies to nervous system-specific proteins are elevated in sera of flight crew members: biomarkers for nervous system injury. J Toxicol Environ Health A. 2013;76(6):363-80. doi: https://doi.org/10.1080/15287394.2013.765369. PMID: 23557235.
  12. Abudukelimu A, Barberis M, Redegeld FA, Sahin N, Westerhoff HV. Predictable Irreversible Switching Between Acute and Chronic Inflammation. Front Immunol. 2018 Aug 7;9:1596. doi: https://doi.org/10.3389/fimmu.2018.01596. PMID: 30131800; PMCID: PMC6090016.
  13. Shi K, Zhang J, Dong JF, Shi FD. Dissemination of brain inflammation in traumatic brain injury. Cell Mol Immunol. 2019 Jun;16(6):523-530. doi: https://doi.org/10.1038/s41423-019-0213-5. Epub 2019 Mar 7. PMID: 30846842; PMCID: PMC6804599.
  14. Sofroniew MV. Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators. Neuroscientist. 2014 Apr;20(2):160-72. doi: https://doi.org/10.1177/1073858413504466. Epub 2013 Oct 8. PMID: 24106265.
  15. Streit WJ. Microglial response to brain injury: a brief synopsis. Toxicol Pathol. 2000 Jan-Feb;28(1):28-30. doi: https://doi.org/10.1177/019262330002800104. PMID: 10668987.
  16. Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S232-40. doi: https://doi.org/10.1038/sj.bjp.0706400. PMID: 16402109; PMCID: PMC1760754.
  17. Freire MAM, Rocha GS, Bittencourt LO, Falcao D, Lima RR, Cavalcanti JRLP. Cellular and Molecular Pathophysiology of Traumatic Brain Injury: What Have We Learned So Far? Biology (Basel). 2023 Aug 17;12(8):1139. doi: https://doi.org/10.3390/biology12081139. PMID: 37627023; PMCID: PMC10452099.
  18. Shi Z, Yu P, Lin WJ, Chen S, Hu X, Chen S, Cheng J, Liu Q, Yang Y, Li S, Zhang Z, Xie J, Jiang J, He B, Li Y, Li H, Xu Y, Zeng J, Huang J, Mei J, Cai J, Chen J, Wu LJ, Ko H, Tang Y. Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes. Neuron. 2023 Mar 1;111(5):696- 710.e9. doi: https://doi.org/10.1016/j.neuron.2022.12.009. Epub 2023 Jan 4. PMID: 36603584.
  19. Ladak AA, Enam SA, Ibrahim MT. A Review of the Molecular Mechanisms of Traumatic Brain Injury. World Neurosurg (2019) 131:126–32. doi: https://doi.org/10.1016/j.wneu.2019.07.039
  20. Edwards KA, Pattinson CL, Guedes VA, Peyer J, Moore C, Davis T, Devoto C, Turtzo LC, Latour L, Gill JM. Inflammatory Cytokines Associate With Neuroimaging After Acute Mild Traumatic Brain Injury. Front Neurol. 2020 May 19;11:348. doi: https://doi.org/10.3389/fneur.2020.00348. PMID: 32508732; PMCID: PMC7248260.
  21. Malik S, Alnaji O, Malik M, Gambale T, Farrokhyar F, Rathbone MP. Inflammatory cytokines associated with mild traumatic brain injury and clinical outcomes: a systematic review and meta-analysis. Front Neurol. 2023 May 12;14:1123407. doi: https://doi.org/10.3389/fneur.2023.1123407. PMID: 37251220; PMCID: PMC10213278.
  22. Vedantam A, Brennan J, Levin HS, McCarthy JJ, Dash PK, Redell JB, Yamal JM, Robertson CS. Early versus Late Profiles of Inflammatory Cytokines after Mild Traumatic Brain Injury and Their Association with Neuropsychological Outcomes. J Neurotrauma. 2021 Jan 1;38(1):53-62. doi: https://doi.org/10.1089/neu.2019.6979. Epub 2020 Aug 5. PMID: 32600167; PMCID: PMC7757539.
  23. Brundin L, Erhardt S, Bryleva EY, Achtyes ED, Postolache TT. The role of inflammation in suicidal behaviour. Acta Psychiatr Scand. 2015 Sep;132(3):192-203. doi: https://doi.org/10.1111/acps.12458. PMID: 26256862; PMCID: PMC4531386.
  24. Fazel S, Wolf A, Pillas D, Lichtenstein P, Långström N. Suicide, fatal injuries, and other causes of premature mortality in patients with traumatic brain injury: a 41-year Swedish population study. JAMA Psychiatry. 2014 Mar;71(3):326-33. doi: https://doi.org/10.1001/jamapsychiatry.2013.3935. PMID: 24430827; PMCID: PMC4058552.
  25. Mackelprang JL, Bombardier CH, Fann JR, Temkin NR, Barber JK, Dikmen SS. Rates and predictors of suicidal ideation during the first year after traumatic brain injury. Am J Public Health. 2014 Jul;104(7):e100-7. doi: https://doi.org/10.2105/AJPH.2013.301794. Epub 2014 May 15. PMID: 24832143; PMCID: PMC4056207.
  26. Ismael S, Ahmed HA, Adris T, Parveen K, Thakor P, Ishrat T. The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury. Neural Regen Res. 2021 Jan;16(1):49- 57. doi: https://doi.org/10.4103/1673-5374.286951. PMID: 32788447; PMCID: PMC7818859.
  27. O’Brien WT, Pham L, Symons GF, Monif M, Shultz SR, McDonald SJ. The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target. J Neuroinflammation. 2020 Apr 6;17(1):104. doi: https://doi.org/10.1186/s12974-020-01778-5. PMID: 32252777; PMCID: PMC7137518.
  28. Bao W, Lin Y, Chen Z. The Peripheral Immune System and Traumatic Brain Injury: Insight into the role of T-helper cells. Int J Med Sci. 2021 Sep 9;18(16):3644-3651. doi: https://doi.org/10.7150/ijms.46834. PMID: 34790036; PMCID: PMC8579286.
  29. Amick JE, Yandora KA, Bell MJ, Wisniewski SR, Adelson PD, Carcillo JA, Janesko KL, DeKosky ST, Carlos TM, Clark RS, Kochanek PM. The Th1 versus Th2 cytokine profile in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatr Crit Care Med. 2001 Jul;2(3):260-264. doi: https://doi.org/10.1097/00130478-200107000-00013. PMID: 12793952.
  30. Barr T, Livingston W, Guardado P, Baxter T, Mysliwiec V, Gill J. Chapter 8 Military Personnel With Traumatic Brain Injuries and Insomnia Have Reductions in PTSD and Improved Perceived Health Following Sleep Restoration: A Relationship Moderated by Inflammation. Annu Rev Nurs Res. 2015;33:249-66. doi: https://doi.org/10.1891/0739-6686.33.249. PMID: 25946388.

Journal’s Indexing:

UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

ДУ «ІНПН імені
П.В. ВОЛОШИНА
НАМН УКРАЇНИ»