UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2023 » Volume 31, issue 4 (117) » THE CONTENT OF GLUCOSE IN THE CEREBROSPINAL FLUID IN PATIENTS WITH DELIRIUM TREMENS WITH COGNITIVE IMPAIRMENTS OF VARYING SEVERITY

THE CONTENT OF GLUCOSE IN THE CEREBROSPINAL FLUID IN PATIENTS WITH DELIRIUM TREMENS WITH COGNITIVE IMPAIRMENTS OF VARYING SEVERITY

Authors

Type of Article

  • Scientific Article

In the Section

  • DIAGNOSTICS AND THERAPY OF MENTAL AND BEHAVIORAL DISORDERS

Key words

Index UDK:
  • 616.853-008.441.13-06

Abstract

The purpose of the work is to determine the glucose content in the cerebrospinal fluid (CSF) and assess the state of the blood-brain barrier (BBB) in patients with delirium tremens (DT) with cognitive impairments (CI) of varying severity

182 men in the acute period of DT were treated. The age of the patients ranged from 22 to 70 years. All patients had manifestations of CI. Two observation groups were formed from patients with DT: with moderately pronounced CI (104 people) and with significantly pronounced CI (78 people). Both groups included patients with manifestations of “classic” DT (diagnosis code according to ICD-10 F10.4) and with signs of various variants of severe DT (F10.43). The DRS R-98 — Delirium Rating Scale — Revised-98 were used to characterize the clinical manifestations of white fever. The duration of the period of mental disorders was additionally assessed. CSF was obtained by lumbar puncture. The concentration of glucose in blood and CSF was determined by the glucose oxidase method. A temporary increase in the level of glucose in the blood is typical for patients with DT, so 7.8 mmol/l was chosen as the upper limit of blood glucose in the study

The state of the BBB was assessed by the simultaneous use of two indicators, namely, the proportion of creatinine content in the CSF relative to its content in the blood, as well as the proportion of urea content in the CSF relative to its content in the blood. The obtained data were processed by the methods of mathematical statistics using Excel 2016 spreadshee

It was established that in patients with DT, an increase in the expressiveness of CI is accompanied by a relative increase in the concentration of glucose in the CSF, which does not go beyond the reference values. The condition of the BBB is assessed as satisfactory. An increase in the concentration of glucose in the CSF in patients with DT correlates with an increase in the characteristic biorhythmic variability of CI. The existence of a previously unknown small cohort of patients with DT with the most pronounced CI, in which the level of glucose in the CSF exceeds that in the blood, has been registered.

Pages

  • 65-71

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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