UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2023 » Volume 31, issue 4 (117) » THE STUDY OF RELATIONSHIPS BETWEEN CLINICAL SYNDROMES AND GENE POLYMORPHISMS OF ACE AND AT2R1 GENES IN PATIENTS WITH CHRONIC VASCULAR ENCEPHALOPATHY

THE STUDY OF RELATIONSHIPS BETWEEN CLINICAL SYNDROMES AND GENE POLYMORPHISMS OF ACE AND AT2R1 GENES IN PATIENTS WITH CHRONIC VASCULAR ENCEPHALOPATHY

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Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 616.831:575.174.015.3

Abstract

This article presents the results of the study of relationships between clinical presentation and polymorphism of the ACE and AT2R1 genes in patients with chronic vascular encephalopathy (CVE). The 145 patients with chronic vascular encephalopathy (CVE) were examined in order to analyze the clinical presentation of the disease. The molecular genetic research was performed in 18 patients. After the complete clinical and neurological examination, such frequency of the syndromes was found: cephalalgic (70.34 %), extrapyramidal (60.00 %), vestibular (61.38 %), asthenic (53.79 %) syndromes, and syndrome of cognitive disorders (66.21 %). When assessing the dependence of the clinical syndromes most often found in patients with CVE on the I/D polymorphism of the ACE gene, it was established that 90.91 % of patients with cephalalgic syndrome, 81.82 % of patients with asthenic syndrome, and 90.91 % of patients with extrapyramidal syndrome are carriers of the D/D genotype. In contrast, all patients with the absence of cephalalgic, extrapyramidal, and asthenic syndromes had the I/I ACE gene genotype. No significant correlations were found between the presence/absence of clinical syndromes and the frequency distribution of genotypes and alleles of the A1166C polymorphic variant of the AT2R1 gene in patients with CVE.

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  • 5-10

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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