24 healthy adults as well as 69 patients with asthenic manifestations (43 patients with chronic ischemia of brain and 26 patients with different types of multiple sclerosis) were examined with using of an original computer modification of tapping. The results of the study showed that parameters of serial motor reactions and their relationship in healthy adults were indicated the stability of the brain functional state and significant influence of cortex regulatory systems on its dynamics according to tasks that are performed. Examination materials of patients indicated the significant reduction of ability of cortex regulatory influences on subcortical non-specific systems under load conditions, reduction of level of interhemispheric interaction as well as availability of non-adaptive changes with reduction of functional state of different types in dynamics of examination. These manifestations were correlated with clinical symptoms severity.

The proposed option of tapping has shown its ability to determine of common features and differences of asthenic syndrome in patients with chronic ischemia and multiple sclerosis in connection with the development of pathological conditions and processes of its compensation. This is very important especially in the early stages of the disease and may be used for assessment of the effectiveness of therapy.