UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2023 » Volume 31, issue 1 (114) » CLINICAL AND GENETIC ASPECT OF RESISTANT DEPRESSION IN ADOLESCENTS

CLINICAL AND GENETIC ASPECT OF RESISTANT DEPRESSION IN ADOLESCENTS

Authors

Type of Article

  • Scientific Article

In the Section

  • DIAGNOSIS AND TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND DRUG-RELATED DISORDERS

Key words

Index UDK:
  • 616.89-008.454-053.6:159.922.73

Abstract

The work considers and distinguishes the psychopathological symptom complexes of depression in adolescents that are resistant to therapy: anxious, obsessive, behavioral. The level of spontaneous and induced mutagenesis in the blood lymphocytes of adolescents with depression was determined in vitro, which was twice the level of chromosomal aberrations after introducing a mutagen into the culture mixture, which indicates a pronounced individual and group hidden chromosomal instability of patients with depression. The constants of the lack of effectiveness of therapeutic intervention in adolescents with depression were determined (infantilism, personal anxiety, cognitive component of depression, noncompliance, addictions, comorbidity of depression with anorexia nervosa, suicidal behavior, recurrent depression, insufficient titration of antidepressant medication, unpleasant side effects of antidepressants).

Pages

  • 70-76

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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