UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2022 » Volume 30, issue 3 (112) » CLINICAL AND PATHOGENETIC PATTERNS OF THE OCCURRENCE OF SOMATIC DISORDERS IN PATIENTS WITH DELIRIUM TREMENS

CLINICAL AND PATHOGENETIC PATTERNS OF THE OCCURRENCE OF SOMATIC DISORDERS IN PATIENTS WITH DELIRIUM TREMENS

Authors

Type of Article

  • Scientific Article

In the Section

  • DIAGNOSIS AND TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND DRUG-RELATED DISORDERS

Key words

Index UDK:
  • 616.853.-008.441.13-06

Abstract

The aim of the study was to study in patients with delirium tremens (DT) changes in the content of non-ionic osmotically active substances in the blood serum, namely the total concentration of glucose and urea, depending on the presence and number of somatic complications. A total of 570 men with DT were included in the study. The age of the patients ranged from 18 to 68 years. In 54 patients, a state of alcohol withdrawal with severe somatovegetative manifestations (diagnosis code F10.3 according to ICD-10) was stated, in 211 people — the presence of “classic” DT (F10.4), and in 305 patients — different variants of severe DT (F10.43). All patients were divided into 4 groups. Observation group 1 consisted of 222 people with DT, whose mental illness was not accompanied by the development of somatic complications. Group 2 included 193 patients with DT, who had one somatic complication during their illness. Observation group 3 consisted of 104 patients who had two somatic complications. Group 4 included 51 patients with DT, each of whom had three or four somatic complications. Four types of somatic complications were taken into account: impaired liver function; impaired renal function; development of acute pneumonia; the development of acute pancreatitis.

We were able to mathematically describe a previously unknown relationship between the level of osmoticity caused by non-ionic osmotically active substances in blood serum and the number of somatic complications in patients with DT. It is expressed by the following formula: Ur + Gl = 1 mmol/l (1.79N + 9.97), where: Ur is the concentration of urea in blood serum, mmol/l; Gl is the concentration of glucose in the blood serum, mmol/l; Ur + Gl — concentration of non-ionic osmotically active substances in blood serum, mmol/l; 1,79 — dimensionless proportionality factor; N is the number of somatic complications in one patient, a dimensionless value; 1 mmol/l — the coefficient necessary to comply with the dimensions of the left and right parts of the formula; 9.97 is a constant, the size of which depends on the chosen system of units. It has been shown that somatic complications take the second place among the clinical manifestations (after indicators of the severity of the mental status) in terms of their impact on the survival of patients with DT.

Pages

  • 98-104

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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