UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2022 » Volume 30, issue 2 (111) » THE EFFECTIVENESS OF REHABILITATION PROGRAMS FOR THE MOBILIZATION OF COMPENSATORY-ADAPTIVE NEUROPLASTICITY PROCESSES IN PATIENTS WITH PARKINSON’S DISEASE ACCORDING TO INDICATORS OF NEUROTROPHIC FACTORS

THE EFFECTIVENESS OF REHABILITATION PROGRAMS FOR THE MOBILIZATION OF COMPENSATORY-ADAPTIVE NEUROPLASTICITY PROCESSES IN PATIENTS WITH PARKINSON’S DISEASE ACCORDING TO INDICATORS OF NEUROTROPHIC FACTORS

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Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

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Index UDK:
  • 612:82:616.831-001-858-008.6

Abstract

The purpose of the study: is to objectively evaluate the effectiveness of non-drug rehabilitation programs for patients with Parkinson’s disease (PD) based on indicators of specific neurotrophic factors.

Sixty-one patients with PD: study group — 33 patients, comparison group — 28 people. There were 33 patients in the experimental group and 28 in the comparison group. The patients of the experimental group did daily physical exercises for two months, unlike the representatives of the comparison group.

Patients of both groups were examined for the serum level of the neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF) and cerebral dopamine neurotrophic factor (CDNF).

In patients with PD of the comparison group, the synchronous dynamics of CDNF and GDNF indicators occurred and characterized the individual course of the disease. On the other hand, in the experimental group, asynchrony of changes of these neurotrophic factors in blood serum was observed under conditions of physical exertion.

Summarizing the data obtained, it is necessary to consider many factors that can affect the level of neurotrophic factors. There is probably a genetically determined heterogeneity of the Parkinson’s disease phenotype, which is also expressed by the features of the synchronous dynamics of CDNF and GDNF parameters. It follows that the initial assessment of these parameters in patients with PD is optimal to identify those for whom motor rehabilitation will cause a long and stable positive effect and ensure the course of the disease according to a favourable type

The multidirectional and asynchrony of changes in neurotrophic factors in blood serum under conditions of physical exertion indicates the "sensitivity" of the system of neurotrophic factors to rehabilitation measures, even if they are used for a short time. Since long-term rehabilitation programs provide positive dynamics in the design of neurotrophic factors, a sufficient duration and regularity of non-drug rehabilitation programs are advisable.

Pages

  • 18-23

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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