UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2021 » Volume 29, issue 2 (107) » Peculiarities of neuroregulatory mechanisms of adaptation under alcohol dependence (experimental study)

Peculiarities of neuroregulatory mechanisms of adaptation under alcohol dependence (experimental study)

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Type of Article

  • Scientific Article

In the Section

  • DIAGNOSTICS AND TREATMENT OF MENTAL AND DRUG ADDICTION DISORDERS

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Abstract

Neurophysiological and biochemical markers of alcohol dependence were identified in a study conducted in laboratory rats at the systemic and molecular levels. It has been shown that long-term alcohol consumption is accompanied by an increase in dopamine levels in the ventral tegmental area and a decrease in GABA and BDNF levels in the hippocampus and serum and leads to attenuation of neocortex control of the limbic emotional-motivational system of the brain. Disturbance of the mechanisms of structural and functional organization of wake-sleep processes and regulation of emotional reactions, which is reflected in the suppression of slow-wave sleep, reduction of paradoxical sleep, inhibition of positive emotional centers, the development of anxiety and depression have been determined.

Pages

  • 36-40

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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