UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325

Stable complexes of neuropsychiatric symptoms in patients with vascular dementia with different localization of brain pathological focuses

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Abstract

The aim of the study was to determine the stable complexes of neuropsychiatric symptoms inherent in patients with vascular dementia with different localization of brain damage.

157 people with a diagnosis of vascular dementia were examined. Group 1 included 22 people with localization of the pathological process in the frontal lobe, group 2 — 18 patients with lesions of the temporal lobe, group 3 — 17 patients with lesions of the parietal lobe, group 4 — 15 patients with lesions of the occipital lobe, group 5 — 68 people with total defeat. All contingents are post-stroke patients over 50 years old, the average age is 68.12 years.

Research methods: clinical-psychopathological, clinical-instrumental, experimental-psychological, anamnestic, clinical-statistical.

The stable complexes (clusters) of neuropsychiatric symptoms inherent in patients with vascular dementia with different localization of brain lesions were determined.

Revealing the following stable associations “localization — cluster”: frontal lobe — subpsychotic cluster (delusion — hallucinations — euphoria — agitation — depression); temporal lobe — asthenoanxiotic cluster (anxiety — irritability — agitation — sleep disturbances — apathy); parietal lobe — excitable-depressive cluster (depression — agitation — irritability — sleep disturbances); occipital lobe — affectocentric cluster (anxiety — depression — agitation — irritability); total defeat — asthenopathoideatoric cluster (apathy — irritability — agitation — anxiety — delirium).

The identification of the association allows one to confidently determine the nature of the expected neuropsychiatric symptoms immediately after obtaining neuroimaging data regarding the localization of the lesion, which creates optimal conditions for the timely formation of a program of appropriate therapeutic interventions.

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References

  1. Mild behavioral impairment as a marker of cognitive decline in cognitively normal older adults / Creese B., Brooker H., Ismail Z. [et al.] // The American Journal of Geriatric Psychiatry. 2019. Vol. 27 (8). P. 823—834. DOI: https://doi.org/10.1016/j.jagp.2019.01.215.
  2. The progression of neuropsychiatric symptoms in Alzheimer’s disease during a five-year follow-up: Kuopio ALSOVA Study  / Hallikainen I., Hongisto K., Välimäki T. [et  ]  // Journal of Alzheimer’s Disease. 2018. Vol. 61, no. 4. P. 1367—1376. DOI: https://doi.org/10.3233/JAD-170697.
  3. Course of neuropsychiatric symptoms in dementia: 5‐year longitudinal study / Vik-Mo AO, Giil L  M, Ballard  [et  al.]  // International journal of geriatric psychiatry. 2018. Vol. 33, no. 10. P. 1361—1369. DOI: https://doi.org/10.1002/gps.4933.
  4. Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease / Borda M. G., Soennesyn H., Steves C. J. [et al.] // Dementia and Geriatric Cognitive Disorders Extra.2019. Vol. 9, no. 1. P. 176—183. DOI: https://doi.org/10.1159/000496537.
  5. Poulin S. P., Bergeron D., Dickerson B. C. Risk factors, neuroanatomical correlates, and outcome of neuropsychiatric symptoms in Alzheimer’s disease  // Journal of  Alzheimer’s Disease. 2017. Vol. 60, no. 2. P. 483—493. DOI: https://doi.org/10.3233/JAD-160767.
  6. Linnemann C., Lang U. Pathways Connecting Late-Life Depression and Dementia  // Frontiersin Pharmacology. 2020. Vol. 11. P. 279. DOI: https://doi.org/10.3389/fphar.2020.00279.
  7. The individual course of neuropsychiatric symptoms in  people with Alzheimer’s and Lewy body dementia: 12-year longitudinal cohort study / Vik-Mo A. O., Giil L. M., Borda M. G. [et al.] // The British Journal of Psychiatry. 2020. Vol. 216, no. 1. P. 43—48. DOI: https://doi.org/10.1192/bjp.2019.195.
  8. Survival time and differences between dementia with Lewy bodies and Alzheimer’s disease following diagnosis: A meta-analysis of longitudinal studies / Mueller C., Soysal P., Rongve  [et al.] // Ageing research reviews. 2019. Vol. 50. P. 72—80. DOI: https://doi.org/10.1016/j.arr.2019.01.005.
  9. Time course of neuropsychiatric symptoms and cognitive diagnosis in  National Alzheimer’s Coordinating Centers volunteers  / Wise    A., Rosenberg  P.  B., Lyketsos  C.  G., Leoutsakos  J.-M.  // Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 2019. Vol.  11. P.  333—339. DOI: https://doi.org/10.1016/j.dadm.2019.02.006.
  10. Shevchenko-Bitensky K. V. Clinical and psychopathological structure of hallucinatory-paranoid disorders in moderate vascular dementia // Ukrainian Journal of Psychoneurology. 2019. Vol. 27, Issue 2 (99). С. 63-67. URL: http://nbuv.gov.ua/UJRN/Uvp_2019_27_2_16.
  11. A comparison of psychiatric symptoms in vascular dementia and Alzheimer’s disease / Sultzer D. L., Levin H. S., Mahler M. E. [et ] // The American journal of psychiatry. 1993. Vol.  150, Issue 12. P. 1806—1812. DOI: https://doi.org/10.1176/ajp.150.12.1806.
  12. Deardorff W. J., Grossberg G. T. Behavioral and psychological symptoms in Alzheimer’s dementia and vascular dementia // Handbook of clinical neurology. Elsevier, 2019. Vol. 165. P. 5—32. DOI: https://doi.org/10.1016/B978-0-444-64012-3.00002-2.
  13. Aymedov K.V., Voloshchuk D.A. Evaluation of the effectiveness of comprehensive medical and social support for patients with vascular dementia // Archives of Psychiatry. 2016. Т. 22, № 3. С. 20-27. URL: http://nbuv.gov.ua/UJRN/apsuh_2016_22_3_6.
  14. O’Brien J. T., Thomas A. Vascular dementia // The Lancet. 2015. Vol. 386, no. P. 1698—1706. DOI: https://doi.org/10.1016/S0140-6736(15)00463-8.
  15. Levada O. A. Specific cognitive and psychopathological syndrome complex of stages of development of subcortical vascular dementia // Archives of Psychiatry. 2013. VOL. 19, NO. 27-32. URL: http://nbuv.gov.ua/UJRN/apsuh_2013_19_3_5.
  16. Cheddock Scale. URL: http://math.semestr.ru/corel/cheddok.php.