UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2020 » Volume 28, issue 1 (102) » Prognostic value and clinical laboratory assessment of connective tissue exchange disorders in the course of children’s traumatic brain injury

Prognostic value and clinical laboratory assessment of connective tissue exchange disorders in the course of children’s traumatic brain injury

Authors

Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 616.831-001-018.2-07-053.2

Abstract

The author of this paper has carried out clinical laboratory assessment of connective tissue disorders with the purpose of the prognostic value of the course of closed craniocerebral injury of children with diff erent severity.

115 children with closed craniocerebral injury with different severity in the age from 3 to 17 were examined. There were 90 boys and 25 girls among them. The average age of children was (13.5 ± 4.5) years.

The distribution of children into groups was carried out according to the clinical forms of traumatic brain injury.

The author has accomplished analysis of certain phenotypological signs among patients of clinical groups. The analysis has demonstrated that the most significant phenotypic markers of patients were: postural disorder (anterior curvature / lateral curvature), hypermobility of the joints, platypodia and myopia.

Biochemical research methods were used to assess the condition of the connective tissue. The content of connective tissue markers has been analyzed (glucosaminoglycans in the blood serum and daily excretion of oxyproline in the urine).

The author has studied biochemical changes on the basis of a comparative analysis of undiff erentiated connective tissue disease (UCTD) phenotypic mar kers among the patients of the clinical groups, which demonstrate that the patients had a decrease of general glucosaminoglycans in the blood serum in the presence of UCTD markers, and their redistribution towards a decrease or increase in the I fraction against the background of a signifi cant decrease in the III fraction and an increase in the uronic acids excretion. An increase in oxyproline was observed due to an increase in collagen catabolism. The changes in the metabolism of proteoglycans and collagen, established during the analysis of the results of biochemical studies, indicate instability and insuffi - ciency of connective tissue structures of the patients’ body with various signs of dysplasia.

Pages

  • 30-35

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References

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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