UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2020 » Volume 28, issue 1 (102) » The individual characteristics of the patients with nonspecifi c back pain aff ecting the dynamics of pain syndrome in the treatment with non-steroidal anti-infl ammatory drugs

The individual characteristics of the patients with nonspecifi c back pain aff ecting the dynamics of pain syndrome in the treatment with non-steroidal anti-infl ammatory drugs

Authors

Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 616.8-009.7:[617.546]-07-08-039.73-036.8

Abstract

The eff ect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of patients with non-specifi c back pain is variable, from complete ineff ectiveness to the occurrence of side eff ects. The eff ect of NSAIDs is aff ected by various factors, including individual characteristics of the patient. The aim of the study was to improve the diagnostic approach to patients with non-specifi c back pain to identify individual indicators that can aff ect the effi cacy and safety of NSAID therapy. The study involved 139 patients — men and women aged 30 to 60 years — with acute nonspeci fic back pain. All patients took meloxicam or celecoxib for 10 days, then observed during 90 days. On the 1st, 10th, 30th and 90th days the patients were assessed on scales — Visual Analog Scale ( VAS), Beck Depression Inventory. In the 1st and 10th days in 20 patients we determined the levels of interleukin 1 (IL-1β), interleukin 6 (IL-6), interleukin 10 (IL-10).

The patients with arterial hypertension (p = 0,0053), diabetes (p = 0.04), depression (p = 0.01) had signifi cantly worse treatment outcomes. Reduction in the levels of IL-1β and the ratio IL-6/IL-10 led to a significant reduction in pain intensity in patients with back pain.

The prescription of NSAIDs for patients with back pain should be assessed from the perspective of the individual patient, including the presence of comorbidity, emotional or genetic markers, and so on, which should increase the efficiency and safety of NSAIDs treatment.

Pages

  • 21-25

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References

  1. Theken K. N. Variability in analgesic response to non-steroidal anti-inflammatory drugs // Prostaglandins & Other Lipid Mediators. 2018; 139: 63—70. DOI: https://doi.org/10.1016/j.prostaglandins.2018.10.005.
  2. Is there an  association between diabetes  and neck pain and lower back pain? Results of a population-based study / R. Jimenez-Garcia, J. L. del Barrio, V. Hernandez-Barrera [et al.] // J Pain Res. 2018; 11: 1005—1015. DOI: https://doi.org/10.2147/JPR.S158877.
  3. Frequent pain  in  older people with and without  diabetes — Finnish community based study / M. Karjalainen, J. Saltevo, M. Tiihonen [et al.] // BMC Geriatrics. 2018 Mar 15; Vol. 18 (1): 73. DOI: https://doi.org/10.1186/s12877-018-0762-y.
  4. The association between obesity and back pain in  nine countries: a  cross-sectional study  / Koyanagi A., Stickley  , Garin N. [et al.] // BMC Public Health. 2015; 15: 123. DOI: https://doi.org/10.1186/s12889-015-1362-9.
  5. The effects of  lifestyle intervention for hypertension on  low back pain: a  randomized controlled trial  / Mattila  , Malmivaara A., Kastarinen M. [et al.] // Spine (Phila Pa 1976). 2007 Dec 15; 32 (26): 2943—7. DOI: https://doi.org/10.1097/BRS.0b013e31815cda33.
  6. Blood pressure and risk of headache: a prospective study of 22 685 adults in Norway / Hagen K., Stovner L. J., Vatten L. [et ]  // J  Neurol Neurosurg Psychiatry. 2002; 72  (4): 463—6. DOI: https://doi.org/10.1136/jnnp.72.4.463.
  7. Prevalence of clinical hypertension in patients with chronic pain compared to nonpain general medical patients / [Bruehl S., Chung O. Y., Jirjis J. N., Biridepalli S.] // Clin J Pain. 2005; 21 (2): 147—53. DOI: https://doi.org/10.1097/00002508-200503000-00006.
  8. al’Absi Mustafa, Buchanan Tony W. , Lovallo William R. Pain perception and cardiovascular responses in men with positive parental history for hypertension // Psychophysiology. 1996; 33 (6): 655—661. DOI: https://doi.org/10.1111/j.1469-8986.1996.tb02361.x.
  9. Heuch I., Hagen K., Zwart J.-A. Does high blood pressure reduce the risk of chronic low back pain? The Nord-Trøndelag Health Study // Eur J Pain. 2014 Apr; 18 (4): 590—8. DOI: https://doi.org/10.1002/j.1532-2149.2013.00398.x.
  10. The association of depression and anxiety with pain: a study from NESDA / de Heer E. W., Gerrits M. M., Beekman A. T. [et al.] // PLoS One. 2014; 9 (10): e106907. DOI: https://doi.org/10.1371/journal.pone.0106907.
  11. Symptoms of Depression and Risk of New  Episodes of  Low  Back Pain: A  Systematic Review and Meta-Analysis  / Pinheiro M. B., Ferreira M. L., Refshauge K. [et al.] // Arthritis Care Res (Hoboken). 2015; 67 (11): 1591—603. DOI: https://doi.org/10.1002/acr.22619.
  12. Potential Risk Factors of Persistent Low Back Pain Developing from Mild Low Back Pain in Urban Japanese Workers / Ko Matsudaira, Hiroaki Konishi, Kota Miyoshi [et al.] // PLoS One. 2014 Apr No. 9  (4): e93924. URL: https://doi.org/10.1371/journal.pone.0093924.
  13. Expectations about recovery from acute non-specific low back pain predict absence from usual work due to chronic low back pain: a systematic review // [Hallegraeff J. M., Krijnen W. P., van der Schans C. P., de Greef M. H.] // J Physiother. 2012; 58 (3): 165—72. DOI: https://doi.org/10.1016/S1836-9553(12)70107-8.
  14. Странчунский Л. С., Козлов С. Н., Кукес В.Г. Петров В. И. Нестероидные про ти во воспалительные средства : методи ческое пособие. 2008. 54 с.
  15. Uçeyler N., Rogausch J. , Toyka K. V., Sommer C. Differen tial expression of  cytokines in  painful and painless neuropathies  // Neurology. 2007. 69: 42—49. DOI: https://doi.org/10.1212/01.wnl.0000265062.92340.a5.
  16. A cohort study comparing the serum levels of pro- or anti-inflammatory cytokines in patients with lumbar radicular pain and healthy subjects / Kun Wang, Jun-Ping Bao, Shu Yang [et al.] // Eur. Spine J. 2016. 25: 1428—1434. DOI: https://doi.org/10.1007/s00586-015-4349-4.
  17. Deng, X., Zhao F., Kang B. & Zhang X. Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration // Exp. Ther. Med. 2016. 11: 1425—1432. DOI: https://doi.org/10.3892/etm.2016.3079.
  18. Inflammatory serum protein profiling of patients with lumbar radicular pain one year after disc herniation / Aurora Moen, Anne-Li Lind, Måns Thulin [et  ]  // Int. J. Inflam. 2016. DOI: https://doi.org/10.1155/2016/3874964.
  19. Association between the plasma levels of mediators of inflammation with pain and disability in  the elderly with acute low back pain: data from the Back Complaints in  the Elders (BACE)—Brazil study / Bárbara de Queiroz; Daniele Pereira; Renata Lopes [et al.] // Spine 2016. 41: 197—203. DOI: https://doi.org/10.1097/brs.0000000000001214.
  20. Gadient, R. A. & Otten U. H. Interleukin-6 (IL-6)— a mole cule with both beneficial and destructive potentials // Prog. Neurobiol. 1997. 52: 379—390. DOI: https://doi.org/10.1016/s0301-0082(97)00021-x.
  21. Cunha, F. , Poole S., Lorenzetti B. B. & Ferreira  S.  H. The  pivotal role of  tumour necrosis factor alpha in  the development of inflammatory hyperalgesia // Br. J. Pharmacol. 1992 107: 660—664. DOI: https://doi.org/10.1111/j.1476-5381.1992.tb14503.x.
  22. Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues / Mohammed    Shamji Lori A., Setton Wingrove Jarvis [et  al.]  // Arthritis Rheum. 2010. 62: 1974—1982. DOI: https://doi.org/10.1002/art.27444.
  23. Association between baseline IL-6 and 1-year recove ry in lumbar radicular pain / E. I. Schistad, A. Espeland, L. M. Pedersen // Eur. J. Pain. 2014. 18: 1394—1401. DOI: https://doi.org/10.1002/j.1532-2149.2014.502.x.
  24. Spanogiannopoulos P., Bess E. , CarmodyR. N. & Turnbaugh  P.  J. The  microbial pharmacists within us: a  metagenomic view of xenobiotic metabolism // Nat. Rev. Microbiol. 2016. 14 (5): 273—287. DOI: https://doi.org/10.1038/nrmicro.2016.17.
  25. Commensal microbiota is fundamental for the development of inflammatory pain / Amaral F.  , Sachs D., Costa V. V. [et al.] // Proc Natl Acad Sci USA. 2008. 105 (6): 2193—2197. DOI: https://doi.org/10.3410/f.1104696.560763.
  26. A role for gut microbiota and the metabolite-sensing receptor GPR43 in a  murine model of  gout  / Angélica T. Vieira Laurence Macia, Izabela Galvão [et al.] // Arthritis Rheum. 2015. 67 (6): 1646—1656. DOI: https://doi.org/10.1002/art.39107.
  27. Bacteria activate sensory neurons that modulate pain and inflammation / Isaac M. Chiu, Balthasar A. Heesters, Nader Ghasemlou [et al.] // Nature. 2013. 501 (7465): 52—57. DOI: https://doi.org/10.1038/nature12479.
  28. Mayer E. , Tillisch K., Gupta A. Gut/brain axis and the microbiota // J. Clin. Invest. 2015. 125  (3): 926—938. DOI: https://doi.org/10.1172/jci76304.

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UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

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