UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2019 » Volume 27, issue 2 (99) » Amyloidosis of the central nervous system: common features of various diseases

Amyloidosis of the central nervous system: common features of various diseases

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Type of Article

  • Scientific Article

In the Section

  • MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS

Key words

Index UDK:
  • 616.894-053.9

Abstract

The elucidation of the molecular mechanisms of the pathological process is an essential condition for the effective therapy and prevention of the disease. During the last decades the medical and social problems caused by so-called misfolding diseases were becoming acute increasingly. Among such diseases a special place belongs to Alzheimer’s, Parkinson’s and Creutzfeldtd — Jakob’s diseases, which are related to the amyloidosis of the central nervous system. All of them are characterized by progressive and irreversible degeneration of brain tissue, which is associated with the deposition of β-structured protein aggregates and the death of nerve cells. Scientifi c achievements of the recent years reveal the general features of the mechanisms of formation and course of these diseases, substantiate the provision on the formation of the embryo of protein aggregation as a key process that leads the course of the disease to a qualitatively new, irreversibly progressive level.

Pages

  • 15-19

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The Scientific and Practical Journal of Medicine

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