We have studied the features of multiple sclerosis course and clinicaldiagnostic diff erences between family and sporadic forms of multiple sclerosis (MS). Using the method of questionnaire and clinic neurological examination on the model of Kharkiv region, we carried out a comparative analysis of different courses of sporadic and family forms of MS. We have examined thirty-seven patients, including 40 persons with family forms and 87 with sporadic ones. Analysis of diff erent time stages for diff erent types of MS course showed the signifi cant diff erences in the clinical structure between sporadic and family forms of the disease. These differences involve such important prognostic clinical indicators as severity and duration of onsets, the completeness and duration of clinical remissions after the onset, the specifi cities of the recurrent stage's course regarding the recurrent and secondary progressive courses of MS, and also the pathways of progression phases forming, the variants of progression for progressive courses (PC) of MS (secondary and primary-progressive), the severity of disability according the EDSS scale. Different patterns of clinical indicators, that were determined in diff erent forms of MS, indicate a more unfavorable prognosis for all types of course of family forms compared with sporadic, primarily for PC.