UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325

Modern opportunities of neuronal protection during the acute period of ischemic stroke

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Abstract

In the study they estimated the effi ciency of intravenous injection of Ceraxon in the dose of 2000 mg per day among patients with moderate and severe acute ischemic stroke with the use of separate scales (NIHSS, Bartel’s Index, mRS) on the 21-st day of treatment and determined the eff ect of the medicine on the total index of neurologic functions recovery, which is expressed by the combination of these scales indices on the 90-th day of observation. Results of the conducted clinical study showed that intravenous injection of Ceraxon during the fi rst 24 hours after the ischemic stroke development appears to be highly eff ective in the treatment of the moderate and severe stroke. The use of Ceraxon development signifi cantly increased the index of full neurologic functions recovery in 3 months after the initiation of therapy in comparison with the control group. Safety of the medicine use appeared similar to the safety of the traditional therapy application.

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References

  1. Burchinsky S.G. New possibilities of neuroprotection // International Neurological Journal. - 2006. - № 4(8). - С. 188-195.
  2. Vinychuk SM, Prokopiv MM Acute ischemic stroke. K.: Naukova Dumka, 2006. 285 p.
  3. Ostrovaya T. V., Chernyi V. I. Cerebroprotection in the aspect of evidence-based medicine // Emergency Medicine. - 2007. - № 2(9). - С. 48-52.
  4. Tanovych A., Alfaro V., Sekades H. H. Citicoline in the treatment of traumatic brain injury // Ukrainian Neurological Journal. 2007. - No. 2. - P. 99-111.
  5. : neu- Adibhatla R. M., Hatcher J. F., Dempsey R. J. Citicoline roprotective mechanisms in cerebral ischemia // J. Neurochem. — 2002. — Vol. 80. — P. 15—23.
  6. Adibhatla R. M., Hatcher J. F. and Dempsey R. J. Phospholipase A2, hydroxyl radicals and lipid peroxidation in transient cerebral ische mia // Antioxid Redox Signal. — 2003. — Vol. 5. — P. 647—654.
  7. Adibhatla R. M., Hatcher J. F. Citidine 5-Diphosphocholine (CDP-choline) in Stroke and other CNS Disorders // Neurochemical Research. — 2005. — Vol. 30(1). — P. 15: 23.
  8. Agut J., Font E., Sacriston A., Urtiz J. A. Radioactivity incorporation into different cerebral phospholipids after oral administration of 14C methyl CDP-choline // Arzneimittel for schung. — 1983. — Vol. 33. — P. 1048—1050.
  9. et al. Effect of CDP-choline on Alberghina M., Viola M., Serra I. the biosynthesis of phospholipids in brain regions during hypoxic treatment // J. Neurosci Res. — 1981. — Vol. 6. — P. 421—433.
  10. Anonymous Cytidine diphosphate choline (citicoline, Somazina) // Arzneim-Forsch. — 1983. — Vol. 33. — P. 1011—1080.
  11. Arakawa S., Perera N., Donnan G. A. Neuroprotection in stroke // ACNR. — 2005. — Vol. 5(5) — P. 10—11.
  12. Astrup J., Siesjo B. K., Symon L. Thresholds in cerebral ischemia — the ischemic penumbra // Stroke. — 1981. — Vol. 12, № 6. — P. 723—725.
  13. : PET Baron J. C. Pathophysiology of acute cerebral ischemia studies in humans // Cerebrovasc. Dis. 1 — 1991. — Supl. 1. — P. 22—31.
  14. et al. Barrachina M, Dominguez I., Ambrosio S. Neuroprotective effect of citicoline in 6-hydroxydopamine treated SH-SYSY human neuroblastoma cells // J. Neurol. Sci. — 2003. — Vol. 215. — P. 105—110.
  15. Chinchilla A., Lopez-Ibor J. J., Vega M. Camarero M. CDP-colinaen la evolucion de las funciones mentales en el syndrome de abstinencia alcoholica // Psiquiat Biol. — 1995. — Vol. 2(5). — P. 171—175.
  16. G Clark W. M., Warach S. J., Pettigrew L. C. ammans R. E., Sabounjian L. A. A randomized dose-response trial of citicoline in acute ischemic stroke patients // Neurology. — 1997. — Vol. 49. — P. 671—678.
  17. et al. A r Clark W. M., Williams B. J., Selzer K. A. andomized efficacy trial of citicoline in patients with acute ischemic stroke // Stroke. — 1999. — Vol. 30. — P. 2592—2597.
  18. Clark W. M., Wechsler L. R., Sabounjian L. A., Schwiderski U. E., for the Citicoline Stroke Study Group. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients // Neurology. — 2001. — Vol. 57. — P. 1595—1602.
  19. utic applications of citicoline Conant R., Schauss A. G. Therape for Stroke and cognitive dysfunctions the elderly: a review of the literature // Alter. Med rew. — 2004. — Vol. 9(1): 17—31.
  20. Corso E. A, Arena M/, Ventimiglia A. et al. La CDP-colina nelle vasculopatie cerebrali: valutazioni cliniche e di semioligia strumentale // Clin. Ther. — 1982. — Vol. 102. — P. 379—386.
  21. et al. Oral citicoline in Davalos A., Castillo J., Alvarez-Labin J. acute ischemic stroke. An individual patient data pooling analysis of clinical trials // Stroke. — 2002. — Vol. 33. — P. 2850—2857.
  22. de la Morena E. Efficacy of CDP-choline in the treatment of senile alterations in memory // Ann N Y Acad Sci. — 1991. — Vol. 640. — P. 233—236.
  23. D’Orlando K. J., Sandage B. W. Citicolone (CDP-choline) mechanisms of action and effects In ischemic brain injury // J. Neurol. Res. — 1995. — Vol. 17. — P. 281—284.
  24. Farooqui A. A., Horrocks L. A., Farooqui T. Glycerophospholipids in brain: their metabolism, incorporation to membranes, functions, and involvement in neurological disorders // Chem. Phys. Lipids. — 2000. — Vol. 106. — P. 1—29.
  25. uroprot Fisher M. Ne ection of acute ischemic stroke. Where are we? // Neuroscientist. — 1999. — Vol. 6. — P. 392—401.
  26. Gladstone D. J., Black S. E., Hakim A. M. Toward wisdom from failure: lessons from neuroprotective stroke trial and new therapeutic directions // Stroke. — 2002. — Vol. 33. — P. 2123-2136
  27. is Grotta J. Neuroprotection unlikely to be effective in humans using current trial designs // Stroke. — 2002. — Vol. 33. — P. 306—307.
  28. Hacke W., Kaste M., Bogonsslavsky J. et al. European Stroke Initiative Executive Committee and the EUSI Writing Committee (2003). European Stroke Initiative Recommendations for Stroke Management — update 2003 // Cerebrovasc. Dis. — 2003. — Vol. 16, № 4. — P. 311—337.
  29. et al. Neuroprotection Hurtado O., Moro M. A., Cardenas A. afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport // Neurobiol. Dis — 2005. — Vol. 18. — P. 336—345.
  30. Katsuki H. and Okuda S. Arachidonic acid as a neurotoxic and neurotrophic substance // Prog. Neurobiol. — 1995. — Vol. 46. — P. 607—636.
  31. Klein J. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids // J. Neural Transm. — 2000. — Vol. 107. — P. 1027—1063.
  32. et al. CDP-choline reduces Krupinski J., Ferrer I., Barrachina M. pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat // Neuropharmacology. — 2002. — Vol. 42. — P. 846—854.
  33. Labiche L. A., Grotta J. C. Clinical Trial for Cytoprotection in Stroke // The Journal of the American Society For Experimental NeuroTherapeutics. — 2004. — Vol. 1(1). — P. 46—70.
  34. — Humana Press Lyden P. D. Thrombolytic therapy for stroke. Totowa, New Jersey, 2001. — 410 p.
  35. Martínez-Vila E., Sieira P. I. Current status and perspectives of neuroprotection in ischemic stroke treatment // Cerebrovasc. Dis. — 2001. — Vol. 11 (suppl 1). — P. 60—70.
  36. Masi I., Giani E., Galli C. Effects of CDP-choline on platelet aggregation and the antiaggregatory activity of arterial wall in the rat // Pharmacol Res Commun. — 1986. — Vol. 18. — P. 273—281.
  37. Mir C., Clotet J., Aledo R. CDP-choline prevents glutamatemediated сell death in cerebellar granule neurons // J. Mol. Neurosci. — 2003. — Vol. 20. — P. 53—60.
  38. ants Muir K. W., Teal Ph. A. Why have neuroprotect failed? Lessons Learned from stroke trials // J. of Neurology. — 2005. — Vol. 252(9). — P. 1011—1020.
  39. Pulsinelli W. Pathophysiology of acute ischemic stroke // Lancet. — 1992. — Vol. 339. — P. 533—536.
  40. : neuro- Rao A. M., Hatcher J. F., Dempsey R. J. CDP-choline protection in transient forebrain ischemia of gerbils // J. Neurosci Res. — 1999. — Vol. 58. — P. 697—705.
  41. Rao A. M., Hatcher J. F., Dempsey R. J. Does CDP-choline modulate phospholipase activities after transient forebrain ischemia? // Brain Res. — 2001. — Vol. 58. — P. 268—272.
  42. -R. Rogalewski A., Schneider A., Ringelstein E. R., Schabitz W. Toward a multimodal neuroprotective treatment of stroke // Stroke. — 2006. — Vol. 37. — P. 1129—1136.
  43. h Saver J. l., Wilterdink J. C oline precursor in acute and subacute human Stroke: A meta-analysis // Stroke. — 2002. — Vol. 33. — P. 353.
  44. Secades J. J., Frontera G. CDP-choline pharmacological and clinical review // Methods Find Exp Clin Pharmacol. — 1995. — Vol. 17. — P. 2—54.
  45. : update and review of its pharmaco- Secades J. J. CDP-choline logic and clinical use // Methods & Find Exp. Clin. Pharmacol. — 2002. — Vol. 24. suppl. B. — P. 1—53.
  46. et al. Citic Secades J. J., Alvarez-Sabin J., Rubio F. oline in intracerebral hemorrhage: a double-blind, randomized, placebocontrolled, multi-centre pilot study // Cerebrovasc. Dis. — 2006. — Vol. 21. — P. 380—385.
  47. Siao C. J., Fernandes S. R. and Tsirka S. E. Cell type-specific roles for tissue plasminogenactivator released by neurons or microglia after excitotoxic injury // J. Neurosci. — 2003. — Vol. 23. — P. 3234—3242.
  48. et al. Treatment of acute cerebral Tazaki Y., Sakai F., Otomo E. infarction with a choline precursor in a multicenter double-blind controlled study // Stroke. — 1988. — Vol. 19. — P. 211—216.
  49. et al. Effect of CDP- Trovarelli G., de Medio G. E., Dorman R. V. choline on ischemia-induced alterations of brain lipid in the gerbil // Neurochem Res. — 1981. — Vol. 6. — P. 821—833.
  50. et al. Levels of anti-inflammatory Vila N., Castillo J., Davalos A. cytokines and neurological worsening in acute ischemic stroke // Stroke. — 2003. — Vol. 34, № 3. — Р. 671—675.
  51. Warach S. J., Pettigrew L. C., Dashe J. F. et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging // Ann. Neurol. — 2000. — Vol. 48. — P. 713—722.