UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Home » Archive of numbers » 2007 » Volume 15, issue 1 (50) » Multiple sclerosis in Ukraine: the prevalence, course, prognosis, treatment, farmakoeconomy

Multiple sclerosis in Ukraine: the prevalence, course, prognosis, treatment, farmakoeconomy

Authors

Type of Article

  • Scientific Article

In the Section

  • PROBLEMATIC ARTICLES
Index UDK:
  • 616.832-004.2-036.2-037-08 (477)

Abstract

In the work it was carried out the complex analysis of prevalence of multiple sclerosis in different regions of Ukraine. There were revealed the factors of risk which were preceding the clinical manifestation of debut. There were presented various types of debuts with different courses of multiple sclerosis in western and eastern regions of Ukraine on the models of Kharkiv and Lviv regions. It was given characteristics of relapses of different degrees with relapsing course of multiple sclerosis. There were revealed different types of progressing stages (progressive, relapsing, steady) with the primary- and secondary-progressive courses which were differed from each other by their mechanisms of formation. The criterions of favorable, unfavorable and indefinite prognosis for different courses of multiple sclerosis were picked out. It was given clinical and pathogenetic description of different courses of multiple sclerosis according to the psychological, neurovisual, neurophysiologic and immunological methods of research. It was grounded the application of the new original technologies of the medical treatment of multiple sclerosis (autotransplantation of stromal cells and endolumbal introduction of glucocorticoids), there were developed approaches for the differentiated application of modern methods of pathogenetic therapy taking into account the stage of activity and type of course of the demielinizative process. The farmakoeconomical ground of medical treatment of the patients with multiple sclerosis was conducted, including the preparations of the preventive action.

Pages

  • 6-21

Year / Issue

Download PDF

References

  1. Gusev, E. I. Multiple sclerosis / Gusev E. I., Demina T. L., Boyko A. N. - M. 1997. N. - M., 1997.
  2. Zavalishin I. A. Multiple sclerosis: selected issues of theory and practice. - М., 2000. - 640 с.
  3. Barkhatova, V. P. Pathophysiology of demyelinating process / Barkhatova V. P., Zavalishin I. A., Baidina E. V. // Journal of neurology and psychiatry. V. // Journal of Neurology and Psychiatry. С. С. Korsakov. - 2002. - № 7. - С. 53-58.
  4. Lisyanyi, N. I. Immunology and immunotherapy of multiple sclerosis / N. I. Lisyanyi. - Kiev, 2003. - 251 с.
  5. Cheknev, S. B. Pathogenesis of MS: immunostimulation or immunodeficiency / S. B. Cheknev // Immunology. - 1994. - № 2. - С. 9-17.
  6. Yarosh O., Yarosh O. Prevalence of MS in Ukraine // Medical Affairs. - No. 9. - 1995. - P. 84-86.
  7. Mayer, David. Social Psychology / David Mayer: 6th ed., rev. and add.; per. from Engl. - St. Petersburg: Piter, 2002. - 752 с.
  8. Ponomarenko V. S., Kyzym M. O., Uzunov F. V. Level and quality of life of the population of Ukraine (monograph) - Kharkiv: Inzek Publishing House, 2003. 226 p.
  9. Voloshyna N.P., Levchenko I.L., Panchenko I.O. Multiple sclerosis in the industrialized city of Kharkiv // Ukrainian Medical Almanac - Vol. 8, No. 4 (supplement) - 2005. - P. 27-29. (Materials of the scientific and practical conference "Modern technologies of prevention and treatment of mental, behavioral and nervous disorders", September 20-22, 2005, Luhansk).
  10. Donald W. NMR in diagnosis, monitoring treatment and epidemiology of multiple sclerosis // Acta Neurol. Scand. — 1995. — P. 52—53.
  11. Kurtzke J. F. MS epidemiology world wide. One view of current status // Ibid. — 1995. — 91(161). — P. 23—33.
  12. Pavlyuk N. E. Features of multiple sclerosis in the Far Eastern region: Author's thesis. ... kand. med. nauk. - Novosibirsk, 1995.
  13. Nehreba T. V. Klinichna diahnostyka riznykh typiv perebihu rozsiianoho sklerozu. Zbirka anket : Svidotstvo pro reiestratsiiu avtorskoho prava na naukovyi tvir No. 8675 vid 31.10.2003. (In Ukrainian).
  14. Progressive course of multiple sclerosis / I. A. Zavalishin, M. N. Zakharova, A. V. Peresadova [et al] // Journal of Neurology and Psychiatry. С. С. Korsakov. 2002. No. 2, special issue. С. 26-31.
  15. Negreba T.V. The course and prognosis of modern forms of multiple sclerosis [Text] / T. V. Negreba. Negreba // Ukrainian Journal of Psychoneurology. - 2006. - Vol. 14, Issue 1(46). - P. 44-46.
  16. McDonald W. J., Fazenas F., Thomson A. D. Diagnosis of multiple sclerosis // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 2003. - No. 2, special issue - P. 4-9.
  17. Blazhei V.Y., Dziuba A.N. Clinic of the debut of multiple sclerosis in Luhansk region // Ukrainian Medical Almanac. 2002. - Vol. 5 - No. 6. - pp. 15-16.
  18. Negreba, T.V. Clinical characteristics of the debut at different types of multiple sclerosis [Text] / T. V. Negreba // Ukrainian Journal of Psychoneurology. - 2003. - Vol. 11, Issue 2(35). - P. 34-36.
  19. Brixman A. M. On the clinical characteristics and diagnostic criteria of the debut of multiple sclerosis // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 1984. - № 2. - С.189-193.
  20. Poser S. M., Paty D. W., Sceinberg l. New diagnostic criteria for multiple sclerosis // Ann Neurol. 1983; 13: 227—231.
  21. Bisaga G. N. Multiple sclerosis. Modern concepts, diagnosis and treatment. - St. Petersburg, Aspet Plus. - 2001. - 41 с.
  22. Negreba T. V. Clinical characteristics of the progredient types of the course of multiple sclerosis // Ibid. 2003. Т. 11, vip. 1 (34). С. 16-18.
  23. Alan J. Thompson, Chris Pohlman, Reinhard Holfeld. Multiple sclerosis: clinical aspects and controversial issues / Translated from English by N. A. Totolyan; Edited by A. A. Skoromets. - SPb.: Politechnika, 2001. - 422 с.
  24. Poser C. M. Exacerbations, activity and progression in multiple sclerosis // Arch. neurol. — 1999. — Vol. 37. — P. 471—474.
  25. Alexeeva T. G., Boyko A. N. N., Gusev E. I. Spectrum of neuropsychological disorders in multiple sclerosis // Journal of Neurology and Psychiatry. С. С. Korsakov. - 2002. - № 11. - С. 15-20.
  26. Enikolopova E. V., Sadalskaya E. V., Nanyan S. B. et al. Neuropsychological analysis of cognitive functions in patients with multiple sclerosis // Proc. of the 2nd International Conference "A. R. Luria and psychology of the 21st century". - М., 2002. - С.50-51.
  27. Shestopalova, L. F. Cognitive disorders in patients with multiple sclerosis / L. F. Shestopalova // Journal of Psychiatry and Medical Psychology. - 2002. - № 1(9). - С. 50-53.
  28. Lobzin S. V., Ivolgin A. F., Vorobyev S. V. et al. Complex diagnostics of vegetative disorders in multiple sclerosis // Neuroimmunology: Mater. All-Russian scientific and practical conference of neurologists. - St. Petersburg, 2005. - С.85.
  29. Taitzlin V. I., Pertsev G. D. Vegetative disorders in patients with multiple sclerosis // Ukrainian Medical Chaos. - 2004. - № 5. - С. 43-46.
  30. Evdokimova O. V., Starikov A. S., Lapkin M. M. et al. The state of the autonomic nervous system and nonspecific adaptation mechanisms in patients with multiple sclerosis // Neurological Bulletin. - 2003. - Vol. XXXV, vol. 1-2. - С. 22-25.
  31. Osteoporosis: epidemiology, clinic, diagnosis, prevention and treatment / Edited by N. A. Korzh et al. - Kharkov: Golden Pages, 2002. - 648 с.
  32. Malashkhia Y. A., Nadareishvili Z. G., Malashkhia N. Y. et al. Brain as an organ of immunity // Journal of Neurology and Psychiatry. С. С. Korsakov. - 1999. - № 9. - С. 62-64.
  33. Biochemical mechanisms of neuroimmune interaction disorders in multiple sclerosis / [Barkhatova V. P., Zavalishin I. A., Khaidarov B. T. et al.] // Journal of Neurology and Psychiatry. С. С. Korsakov. - 2000. - № 11. - С. 42-47.
  34. Dzyuba, A. N. Indicators of cellular immunity in patients with multiple sclerosis / Dzyuba AN, Frolov VM, Gaidash IS // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - Т. 92. - Vol. 2. - 1992. - С. 12-14.
  35. Comparative clinical and immunochemical analysis of remitting and secondary progressive course of multiple sclerosis / [Gusev E. I., Belyaeva I. A., Chekhonin V. P. et al] // Ibidem. - 2000. - № 6: - С. 51-57.
  36. Remitting and progressive multiple sclerosis: immunopathogenetic differences / [Bisaga G. N., Kalinina N. M., Akimova S. B., Davydova N. I.] // Medical and social aspects of MS. - SPb.: Liki Rossii, 2001. - С. 17-21.
  37. Koliada T. I., Voloshina N. P., Nehreba T. V. Porivnialna kharakterystyka imunnoho statusu pry riznykh typakh perebihu rozsiianoho sklerozu. Ukrainskyi visnyk psykhonevrolohii. 2004. T. 12, vyp. 2 (39). S. 88-94.
  38. Gusev E. I., Demina T. L., Tatarinova M. Yu et al. Use of NMR tomography for dynamic monitoring of patients with multiple sclerosis // Journal of Neurol. and Psychiatry. - 1993, vol. 4. - С. 3-7.
  39. Vavilov S. B., Knorin E.A., Pushkina E. A et al. Magnetic resonance tomography in the diagnosis of brain diseases // Medical Radiology. - 1992. - № 2. - С. 28-33.
  40. Vereshchagin N. V., Khondkarian O. A., Adarcheva L. S. et al. On criteria of pathologic process activity in multiple sclerosis (clinical-computer tomographic comparisons) // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 1985. - № 8. - С. 1121-1126.
  41. Gnezditsky V. В. Evoked brain potentials in clinical practice. Taganrog : TRTU Publishing House, 1997. 252 с.
  42. Sokolova L. I. Visual evoked potentials in patients with multiple sclerosis // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 1982. - № 2. - С.183-189.
  43. Ebers G. C. Treatment of multiple sclerosis // Lancet. — 1994. — P. 275—279.
  44. Lowitzsch. Новые подходы к лечению рассеянного склероза // Неврологический вестник. — 1999. — № 4. — С. 90—91.
  45. Gusev E. I., Boyko A.. N. Some clinical and medico-social aspects of new methods of pathogenetic treatment of multiple sclerosis // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 2001. - № 4. - С. 61-65.
  46. Levin O. S. Immunotherapy of multiple sclerosis // Russian Medical Journal. - М., 2001. - № 22. - С.3-7.
  47. Sokolova L. I. Differentiated treatment of MS patients // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 1997. - № 3. - С. 93-95.
  48. Gusev E. I., Boyko A. N., Poser C. Problems in the future use of B-interferons and copaxone in the treatment of MS // Ibid. - 1999. - № 4. - С. 33-37.
  49. Gusev E. I., Boyko A.. N. Rebif in long-term immunocorrection in multiple sclerosis // Journal "Treatment of Nervous Diseases". - Moscow, 2001. - № 2. - С. 16-19.
  50. Demina T. L., Khachanova N. V., Lashch N. Yu et al. Betaferon in the treatment of patients with multiple sclerosis // Ibidem. - С. 13-16.
  51. Zavalishin I. A., Peresedova A. V. Modern possibilities of pathogenetic treatment of multiple sclerosis // Ibid. V. Modern possibilities of pathogenetic treatment of multiple sclerosis // Ibidem. - С. 3-7.
  52. Zavalishin I. A., Schmidt T. E., Yakhno N. et al. Copaxone in the treatment of patients with multiple sclerosis // Ibidem. - С.19-22.
  53. Voloshyna N.P., Shestopalova L.F., Negreba T.V. et al. Copaxone in the treatment of patients with multiple sclerosis // Ukrainian Journal of Psychoneurology. - 2002. - Vol. 10, Issue 2 (31). - P. 199-202.
  54. Richard A. Radick, Donald E. Goodkin. Therapy of Multiple Sclerosis - Moscow: Dunitz - London, 2000. - 573 p.
  55. Schmidt T. E. Treatment of multiple sclerosis // Russian Medical Journal. - 2001. - Т. 9, № 7-8. - С. 322-328.
  56. Lisich-Williamson K. A., Plocker G. L. Therapy of remitting multiple sclerosis. Determination of the role of interferon beta-1 for subcutaneous administration // Ukrainian Medical Chasopis. - К., 2002. - № 3. - С. 56-76.
  57. Sanchez-Ramos J., Song S., Cardozo-Pelaez F.et al. Adult bone marrow stromal cells differentiate into neural cells in vitro // Experimental Neurology. — 2000, V. 164. — № 2. — P. 247—256.
  58. Prockop D. J., Azizi S. A., Phinney D. G., Kopen G. C., Schwarz E. J. Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system // Prog. Brain Research. — 2000. — V. 128. — P. 293—297.
  59. Woodbury D., Schwarz E. J., Prockop D. J., Black I. B. Adult rat and human bone marrow stromal cells differentiate into neurons // Journal Neuroscience Research. — 2000. — V. 61. — № 4. — P. 364—370.
  60. Neretin V. Ya. Ya., Gannushkina IV, Zhirnova IG et al. Dynamics of immunologic parameters in the treatment of patients with multiple sclerosis prednisolone in combination with plasmapheresis // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 1988. - № 2. - С. 17-21.
  61. Negreba T.V. Clinical efficacy of hormone therapy in relapsing-remitting multiple sclerosis // Ukrainian Journal of Psychoneurology, Vol. 11, Issue 4 (37), 2003, pp. 26-28.
  62. Kolomenskaya E. A., Andreeva I. I., Ibragimova G. V. et al. Effectiveness and side effects of the use of corticosteroid drugs in high doses every other day // Journal of Neuropathology and Psychiatry. С. С. Korsakov. - 1983. - № 4. - С. 531-536.
  63. Neretin V. Ya. Ya., Kiryakov VA, Sapfirova VA Application of corticosteroids in the complex therapy of neurological diseases // Ibid. - 1991. - № 2. - С. 103 - 107.
  64. Voloshina N. P., Vasilovsky V. V., Mikulinsky Y. E., Schegelskaya E. A. Autotherapy with bone marrow stromal cells (BMSCM), induced into nerve cells in patients with progredient forms of multiple sclerosis // 3rd Russian Congress on Pathophysiology with international participation "Dysregulatory pathology of organs and systems (experimental and clinical pathophysiology)": Abstracts - M., 2004. - С. 222-223.
  65. "Method of treatment of patients with multiple sclerosis" of 02.10.2003, Kyiv, Ukrpatent, code of the research work: AMS RS 03, title of the research work: "Development of new technologies for the treatment of multiple sclerosis in the experiment and in the clinic". Patent authors: Head of the Department of Neuroinfections and Pathology of the CNS, Doctor of Medicine, Professor Voloshyna N.P., Senior Researcher, Candidate of Medicine Vasylovsky V.V. Ukraine (19) UA, (11) 68711 A "Method for treatment of patients with multiple sclerosis"
  66. "Method of treatment of patients with multiple sclerosis" of 02.10.2003, Kyiv, Ukrpatent, code of the research work: AMS RS 03, title of the research work: "Development of new technologies for the treatment of multiple sclerosis in the experiment and in the clinic". Patent authors: Head of the Department of Neuroinfections and Pathology of the CNS, Doctor of Medicine, Professor Voloshyna N.P., Senior Researcher, Candidate of Medicine Vasylovsky V.V. Ukraine (19) UA, (11) 68711 A "Method for treatment of patients with multiple sclerosis"
  67. Zhirnova I. G., Gannushkina I. V., Labunskaya D. A. et al. A. et al. Immunologic indices and efficiency of plasmapheresis // Neuroimmunology, neuroinfection, neuroimage: Mater. conf. - St. Petersburg, 1995. - С.43-45.
  68. Anastasiev V. V. Immunoglobulin for intravenous administration. - Nizhny Novgorod, 2000. - 166 с.
  69. Sorensen P. S., Wanscher B. et al Intravenous immunoglobulin reduces MRI activity in relapsing multiple sclerosis // Neurology. — 1998. — Vol. 50. — P. 1273—1284.
  70. Link Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid chemical and immunological characterization with special reference to multiple sclerosis // Acta Neurol. Scand. — 1967. — Vol. 43, Suppl 28. — P. 1—136
  71. Odinak MM, Bisaga GN, Zarubina IV New approaches to antioxidant therapy in multiple sclerosis // Journal of Neurology and Psychiatry. С. С. Korsakov. - 2002. - № 2. - С. 72-75.
  72. Kolendo O.O. Application of berlition and neomidantan in the complex treatment of patients with MS with fatigue // Ukrainian Journal of Psychoneurology. - 2004. - Vol. 12, Issue 2 (39). - P. 38-41.
  73. Vinychuk S.M., Donchenko G.V., Kopchak O.O. et al. Efficacy of Berlition in the treatment of patients with multiple sclerosis with fatigue and its effect on the state of prooxidant-antioxidant balance // Ukrainian Medical Journal. 2004. - 5/43 IX-X. - P. 36-42.
  74. Kolendo O.O. Application of Berlition and Neomidantan in the complex treatment of patients with multiple sclerosis with fatigue // Berlin-Chemie Representative Office in Ukraine. - 2003. - 4 p.
  75. Odinak MM, Bisaga GN, Zarubina IV New approaches to antioxidant therapy in multiple sclerosis // Journal of Neurology and Psychiatry. С. С. Korsakov. - 2002. - № 2. - С. 72-75.
  76. Voloshyna N.P., Vasylovskyi V.V., Chernenko M.E. The use of the drug mitoxantrone in the treatment of patients with progressive type of multiple sclerosis // Ukrainian Journal of Psychoneurology. - 2005. - Vol. 13, Issue 3 (44). - P. 53-55.
  77. Schmidt T.E., Yakhno N.N. Multiple sclerosis. Moscow : Medicine, 2003.
  78. Schwartz G. Y. Pharmacoeconomic justification of the use of preventive drugs in the treatment of patients with multiple sclerosis // Neurological Journal. - 2001. - Т. 6, № 1. - С.43-47.
  79. Andlin-Sobocki P., Jonsson B., Wittchen H.-U., Olesen J. Cost of disorders of the brain in Europe // European Journal of Neurology. — 2005, 12 (Suppl.). — P. 1—27.

Journal’s Indexing:

UKRAINS'KYI VISNYK PSYKHONEVROLOHII

The Scientific and Practical Journal of Medicine

ДУ «ІНПН імені
П.В. ВОЛОШИНА
НАМН УКРАЇНИ»