ГоловнаArchive of numbers2024Volume 32, issue 2 (119)Participation of the autonomic system in tremorogenesis and possible ways of its correction (literature review)
Title of the article Participation of the autonomic system in tremorogenesis and possible ways of its correction (literature review)
Authors Stoianov Oleksandr
Son Anatoliy
Vastianov Ruslan
Kalashnikov Valerii
Mirjuraev Jakhongir
In the section LITERATURE REVIEW
Year 2024 Issue Volume 32, issue 2 (119) Pages 82-89
Type of article Scientific article Index UDK 611.83:616.8-009.3-08 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V32-is2-2024-13

 Tremor is the most common hyperkinesis. There is evidence that tremor often occurs in the event of a disturbance in the integrative activity of the central nervous system involving structures that relate to non-specific brain systems. The analysis of own and available in the literature clinical and experimental data on the effect on tremorogenesis of the vegetative system was carried out. Pathogenetically justified ways of correction were evaluated. In experimental studies, the participation of monoaminergic neurotransmitters in both tremorogenesis and autonomic dysfunctions has been revealed and confirmed. Our research and analysis of literary sources make it possible, in addition to diagnosis, to assess the balance of vegetative support, which improves adequate therapy.
Key words tremor, tremorogenesis, autonomic system, diagnosis, central and peripheral nervous system, treatment
Access to full text version of the article pdf download
Bibliography 1. Kurako Yu.L., Stoyanov A.N. Tremor v klinicheskoj nevrologii. Odessa. OGMU. 2000. 128 p. (In Russian).
2. Louis ED, Bares M, Benito-Leon J, Fahn S, Frucht SJ, Jankovic J, Ondo WG, Pal PK, Tan EK. Essential tremor-plus: a controversial new concept. Lancet Neurol. 2020 Mar;19(3):266- 270. doi: 10.1016/S1474-4422(19)30398-9. Epub 2019 Nov 22. PMID: 31767343; PMCID: PMC10686582.
3. Bain PG. Parkinsonism & related disorders. Tremor. Parkinsonism Relat Disord. 2007; 13 (Suppl 3): S369-74. doi: 10.1016/ S1353-8020(08)70032-4. PMID: 18267266.
4. Bermejo-Pareja F. Essential tremor — a neurodegenerative disorder associated with cognitive defects? Nat. Rev. Neurol. 2011 May; 7(5): 273-82. doi: 10.1038/nrneurol.2011.44. Epub 2011 Apr 12. PMID: 21487422.
5. Stoyanov A. N., Skorobrekha V. Z. Kliniko-instrumentalnaya diagnostika drozhatelnykh giperkinezov : monografiya. Odessa : VMV, 2017. 84 p. (In Russian).
6. Ortiz, G. G., González-Usigli, H., Pacheco-Moisés, F. P., Mireles-Ramírez, M. A., Sánchez-López, A. L., Torres-Sánchez, E. D., … González, V. S. (2017). Physiology and Pathology of Neuroimmunology: Role of Inflammation in Parkinson’s Disease. InTech. doi: 10.5772/intechopen.70377.
7. Orekhova M. G. Klinika, patogenez i lecheniye narusheniy dvigatelnoy sfery u bolnykh nevrozopodobnymi sostoyaniyami : avtoref. dis. … d-ra med. nauk. Kharkov, 1991. 73 s. (In Russian). 8. Testa M., Claudia and Dietrich Haubenberger (eds.), Tremors (New York, 2022; online edition, Oxford Academic, August 1, 2022), https://doi.org/10.1093/med/ 9780197529652.001.0001, accessed 18 Apr. 2024.
9. Bologna M, Berardelli I, Paparella G, Ferrazzano G, Angelini L, Giustini P, Berardelli A. Tremor Distribution and the Variable Clinical Presentation of Essential Tremor. The Cerebellum. 2019 Oct;18(5):866-872. doi:10.1007/s12311-019-01070-0. PMID: 31422549. 
10. Deuschl G., Raethjen J., Lindemann M., Krack P. The pathophysiology of tremor. Muscle and Nerve 2001 Jun;24(6):716-35. doi: 10.1002/mus.1063. PMID: 11360255.
11. Likhachev S. A. Vashchilin V. V., Dik S. K. Tremor: fenomenologiya i sposoby registratsii. Meditsinskiy zhurnal. 2010;2:133- 137. http://rep.bsmu.by/handle/BSMU/2709. (In Russian).
12. Louis ED. Tremor. Continuum (Minnip Minnesota). 2019 August; 25(4): 959-975. doi: 10.1212/CON.0000000000000748. PMID: 31356289.
13. Chunling W, Zheng X. Review on clinical update of essential tremor. Neurol Sci. 2016 Apr;37(4):495-502. doi: 10.1007/ s10072-015-2380-1. Epub 2016 Jan 9. PMID: 26749268.
14. Nassar M.H., Tageldin E.A. and Ragab O.A. Evaluation of the autonomic nervous system in patients with essential tremor. Egypt J Neurol Psychiatry Neurosurg 59, 156 (2023). https://doi.org/10.1186/s41983-023-00754-z.
15. Rekik А., Nasri А., Kachem І., Garguri А., Ben Djebara М.,Guider R. Autonomic dysfunction in patients with essential tremor. Journal of the Neurological Sciences. Poster Session 3: 275. October 15, 2019. DOI: https://doi.org/10.1016/j. jns.2019.10.1332.
16. Karaban I. N. Sosudistyy parkinsonizm: vozmozhnost i/ ili obyektivnaya realnost. Mizhnarodnyi nevrolohichnyi zhurnal. 2016;3(81):25-32. http://nbuv.gov.ua/UJRN/Mnzh_2016_3_4. (In Russian).
17. Michiel F. Dirkx, Matteo Bologna, The pathophysiology of Parkinson’s disease tremor, Journal of the Neurological Sciences, Volume 435, 2022, 120196, https://doi.org/10.1016/j. jns.2022.120196.
18. Titova N. V., Chauduri K. R. Nemotornyye simptomy bolezni Parkinsona: podvodnaya chast aysberga. Annaly klinicheskoy i eksperimentalnoy nevrologii. 2017; 11(4): 5–18. DOI: 10.18454/ACEN.2017.4.1. (In Russian).
19. Levin O. S., Makedonskiy P. V., Smoleshcheva I. G., Lycheva N. Yu. Neyropsikhologicheskiye narusheniya u bolnykh essentsialnym tremorom. Nevrologicheskiy zhurnal. 2005; 10 (4): 25-32. (In Russian).
20. Vastyanov R. S., Stoyanov A. N., Bakumenko I. K. Sistemnaya patologicheskaya dezintegratsiya pri khronicheskoy ishemii mozga. Eksperimentalno-klinicheskiye aspekty. Saarbrucken: LAP Lambert Academic Publishing. 2015. 169 p. (In Russian).
21. Fiziologiya cheloveka. Obshchaya fiziologiya : uchebnoye posobiye dlya studentov inostrannogo fakulteta / pod red. V. P. Mishchenko. Poltava, 2005. 104 s. http://repository.pdmu. edu.ua/handle/123456789/17634. (In Russian).
22. Tantik Pak A, Otcu H, Sengul HS, Corakci Z, Sengul Y, Alkan A. Cognitive and brain micro-structural correlates of alexithymia in essential tremor patients. Appl Neuropsychol Adult. 2022 Jul-Aug;29(4):536-545. doi: 10.1080/23279095.2020.1786693. Epub 2020 Jul 11. PMID: 32657147.
 23. Haubenberger D, Hallett M. Essential Tremor. N Engl J Med. 2018 May 10;378(19):1802-1810. doi: 10.1056/NEJMcp1707928. PMID: 29742376.
24. Stoyanov A. N. Neyrovegetologiya neyropaticheskoy boli : uchebnoye posobiye. Kiev : EDVANS-PRINT, 2015. 42 s. http://repo.odmu.edu.ua:80/xmlui/handle/123456789/3015. (In Russian).
25. Samuels’s Manual of Neurologic Therapeutics / Martin Samuels, Allan H. Ropper. 9th Edition. 2017. 744 p. 9781496360311.
26. Louis ED. Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry. Lancet Neurol. 2010 Jun;9(6):613-22. doi: 10.1016/S1474-4422(10)70090- 9. Epub 2010 May 5. PMID: 20451458.
27. Akhmadeeva L. R., Kharisova E. M., Derevyanko Kh. P. Role of cerebellum in formation of postural and cognitive functions: clinical example with schmahmann syndrome. Perm Medical Journal. 2017. 34. 87-91. 10.17816/pmj34687-91. doi: 10.17816/pmj34687-91. (In Russian).
28. Golubev V. L., Veyn A. M. Nevrologicheskiye sindromy : rukovodstvo dlya vrachey. 7-e izd. Moskva : MEDpressinform, 2019. 736 s.
29. Ondo W. Essential Tremor: What We Can Learn from Current Pharmacotherapy. Tremor Other Hyperkinet Mov (N Y). 2016 Mar 4;6:356. doi: 10.7916/D8K35TC3. PMID: 26989572; PMCID: PMC4790207.
30. Handforth A. Harmaline tremor: underlying mechanisms in a potential animal model of essential tremor. Tremor Other Hyperkinet Mov (N Y). 2012;2:02-92-769-1. doi: 10.7916/D8TD9W2P. Epub 2012 Sep 12. PMID: 23440018; PMCID: PMC3572699.
31. Karlov V. A. Nevrologiya : rukovodstvo dlya vrachey. M. : Medinformagentstvo, 1999. 624 s. (In Russian).
32. Govorova T. G., Tappakhov A. A., Popova T. E., Antipina U. D. Tremor: klassifikatsiya, klinicheskaya kharakteristika Consilium Medicum. 2018; 20 (9):95–100. doi: 10.26442/2075- 1753_2018.9.95-100. (In Russian).
33. Khramtsov D. M. Moduliatsiia vnutrishnostriarnoi neirotransmisii pry eksperymentalnomu pisliatravmatychnomu parkinsonizmi. Aktualni problemy suchasnoi medytsyny: Visnyk Ukrainskoi medychnoi stomatolohichnoi akademii. 2012. T. 12, vyp. 4 (40). S.187—190. (In Ukrainian).
34. Karaban I. N. Bolezn Parkinsona: patogeneticheskiye aspekty lekarstvennoy terapii i klinicheskogo techeniya. Mizhnarodnyi nevrolohichnyi zhurnal. 2011; 6:31-38.
35. Ostrow L, Jessell L, Hurd M, Darrow SM, Cohen D. Discontinuing Psychiatric Medications: A Survey of Long-Term Users. Psychiatr Serv. 2017 Dec 1;68(12):1232-1238. doi: 10.1176/appi. ps.201700070. Epub 2017 Jul 17. Erratum in: Psychiatr Serv. 2022 Jul;73(7):744. PMID: 28712356.
36. Leta V, Urso D, Batzu L, Lau YH, Mathew D, Boura I, Raeder V, Falup-Pecurariu C, van Wamelen D, Ray Chaudhuri K. Viruses, parkinsonism and Parkinson's disease: the past, present and future. J Neural Transm (Vienna). 2022 Sep;129(9):1119- 1132. doi: 10.1007/s00702-022-02536-y. Epub 2022 Aug 29. PMID: 36036863; PMCID: PMC9422946.
37. Blakemore RL, MacAskill' MR, Shoorangiz R, Anderson TJ. Stress-evoking emotional stimuli exaggerate deficits in motor function in Parkinson's disease. Neuropsychologia. 2018 Apr;112:66-76. doi: 10.1016/j.neuropsychologia.2018.03.006. Epub 2018 Mar 6. PMID: 29522760.
38. Belinskiy, Artem & Devishvili, Vazha & Chernorizov, Aleksandr & Lobin, Mihail. Influence of emotional tension on tremor parameters in the writing process. World of Science. Pedagogy and psychology. 2023. 11. 10.15862/28PSMN123.
39. Cocoros NM, Svensson E, Szépligeti SK, Vestergaard SV, Szentkúti P, Thomsen RW, Borghammer P, Sørensen HT, Henderson VW. Long-term Risk of Parkinson Disease Following Influenza and Other Infections. JAMA Neurol. 2021 Dec 1;78(12):1461- 1470. doi: 10.1001/jamaneurol.2021.3895. PMID: 34694344; PMCID: PMC8546623.
40. Bigman DY, Bobrin BD. Von Economo's disease and postencephalitic parkinsonism responsive to carbidopa and levodopa. Neuropsychiatr Dis Treat. 2018 Apr 4;14:927-931. doi: 10.2147/NDT.S153313. PMID: 29670352; PMCID: PMC5894716.
41. Stoyanov A. N., Kolesnik E. A., Borisenko O. A. Korrektsiya drozhatelnykh giperkinezov pri vegetativnykh i sosudistykh disfunktsiyakh. Dosiahnennia biolohii ta medytsyny. 2016;2:49-54.
42. Stoyanov O.M. Kolesnyk O.O. Mozhlyvosti terapii dryzhalnykh hiperkyneziv pry vehetatyvnykh ta sudynnykh dysfunktsiiakhiu. Ukrainskyi visnyk psykhonevrolohii [Ukrainian Bulletin of Psychoneurology]. 2017;25(1):107-108. (In Ukrainian).
43. Stoyanov, A. N., Vastyanov R.S. Tremor pri vegetativnykh i sosudistykh disfunktsiyakh. Vozmozhnosti terapii. Ukrainskyi medychnyi almanakh. 2011;14(4):98-101. (In Russian).
44. Filipović Grčić P, Džamonja G, Filipović Grčić A, Dolić K, Matijaca M, Titlić M. Regression of Asymmetric Upper Extremity Tremor After Liver Transplantation in a Patient With Hepatic Encephalopathy: Case Report. Acta Clin Croat. 2018 Mar;57(1):181-186. doi: 10.20471/acc.2018.57.01.25. PMID: 30256030; PMCID: PMC6400343.
45. Shavlovskaya O.A., Bayduletova A.YU. Psikhogennaya distoniya. Annaly nevrologii.ru. 2016. 10:4;62-66. https://annalynevrologii. com/journal/pathID/article/view/23/125. (In Russian).
46. Kim Y, Kim JW. Toxic encephalopathy. Saf Health Work. 2012 Dec;3(4):243-56. doi: 10.5491/SHAW.2012.3.4.243. Epub 2012 Nov 30. PMID: 23251840; PMCID: PMC3521923.
47. Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G; Tremor Task Force of the International Parkinson and Movement Disorder Society. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018 Jan;33(1):75-87. doi: 10.1002/mds.27121. Epub 2017 Nov 30. PMID: 29193359; PMCID: PMC6530552.
48. Stoyanov A. N., Vastyanov R. S., Kubareva D. A., Bakumenko I. K., Kubarev A. V. Effektivnost primeneniya noofena dlya korrektsii vegetativnykh disfunktsiy u podrostkov s tserebralnymi angiodistoniyami i motornymi rasstroystvami. Ukrainskyi visnyk psykhonevrolohii [Ukrainian Bulletin of Psychoneurology]. 2012. 20; 4 (73): 114-119. (In Russian).
49. Baizabal-Carvallo JF, Morgan JC. Drug-induced tremor, clinical features, diagnostic approach and management. J Neurol Sci. 2022 Apr 15;435:120192. doi: 10.1016/j.jns.2022.120192. Epub 2022 Feb 19. PMID: 35220110.
50. Levin O.S., Shtulman D.R. Nevrologiya. Spravochnik prakticheskogo vracha. M. : MedPress-Inform, 2022. 880 с. ISBN 978-5-907504-34-9.
51. Amlang CJ, Trujillo Diaz D, Louis ED. Essential Tremor as a "Waste Basket" Diagnosis: Diagnosing Essential Tremor Remains a Challenge. Front Neurol. 2020 Mar 25;11:172. doi: 10.3389/fneur.2020.00172. PMID: 32269548; PMCID: PMC7109309.
52. Voronkova K. V., Nikitin A. E., Rudakova I. G., Vlasov P. N., Burd S. G., Lebedeva A. V., Avakyan G. N. Sovremennyy vybor antiepilepticheskoy terapii: etapy i rekomendatsii. Epilepsiya i paroksizmalnyye sostoyaniya. 2018;10 (2): 74-81. https://doi. org/10.17749/2077-8333.2018.10.2.074-081. (In Russian).
53. Guseinova RM, Prosvirnina AA, Korchagina MO, Trukhin AA, Sheremeta MS. [Thyrotoxicosis in a patient with Turner syndrome: radioactive iodine therapy]. Probl Endokrinol (Mosk). 2022 Jul 25;68(6):49-58. doi: 10.14341/probl13132. PMID: 36689711; PMCID: PMC9939966. (In Russian).
54. Sposib likuvannia tremoru pry tserebralnykh anhiodystoniiakh. Patent Ukrainy 122897. Stoianov O. M., Kolesnyk O. O., Mashchenko S. S. ta in. A 61K 31/00, 31/4412, N 1/18, 2/00 (2006.01) Biul. № 2 vid 25.06.2018. (In Ukrainian).
55. Borysenko O.A. Kliniko-patohenetychni osoblyvosti vehetatyvnykh rozladiv ta yikh korektsiia v uchasnykiv ATO u viddalenomu periodi cherepno-mozkovoi travmy. Avtoreferat dys… kand. med. nauk. Uzhhorod, 2020. 21 s. (In Ukrainian).
56. Kolesnyk O.O. Kliniko-patohenetychni osoblyvosti i korektsiia hiperkinetychnykh rozladiv pry vehetatyvnykh dysfunktsiiakh. Ukrainskyi visnyk psykhonevrolohii [Ukrainian Bulletin of Psychoneurology]. 2020. 28; 1 (102): 6-9. https://doi. org/10.36927/20790325-V28-is1-2020-1. (In Ukrainian).
57. Karaban I. N., Lukhanina E. P., Melnik N. A., Berezetskaya N. M. Vliyaniye kursovogo lecheniya noofenom na dvigatelnuyu aktivnost, kognitivnyye funktsii i psikhoemotsionalnoye sostoyaniye u bolnykh boleznyu Parkinsona. Ukrainskyi visnyk psykhonevrolohii [Ukrainian Bulletin of Psychoneurology]. 2008;14, 1 (46): 46-50. (In Russian).
58. Stoyanov A. N., Son A. S., Bakumenko I. K., Lebed E. P, Vastyanov R. S. Patogeneticheskaya korrektsiya nekotorykh motornykh komponentov pri vegetativnykh i sosudistykh disfunktsiyakh. "Future research". Mater. X Inter. scientific-practical conference Sofia: ”BialGRAD-BG” 2014; 37:39-44. (In Russian).
59. Sposib likuvannia tremoru. Patent Ukrainy 70543. Stoianov O.M., Son A.S., Vastianov R.S. ta in. A 61K 31/00 (2006.01) Biul. № 11 vid 11.06.2012. (In Ukrainian).
60. Mironenko T. V., Khramtsov D. N., Karpov S. M., Stoyanov A. N., Vastyanov R. S., Bakumenko I. K., Yamkovaya T. G. Kompleksnaya korrektsiya motornykh i neyrovegetativnykh rasstroystv u patsiyentov s posttravmaticheskim parkinsonizmom. Sovremennyye problemy nauki i obrazovaniya. 2013;5. URL: https:// science-education.ru/ru/article/view?id=10079. (In Russian).