Український вісник ПСИХОНЕВРОЛОГІЇ

Науково-практичний медичний журнал
ISSN 2079-0325(p)
DOI 10.36927/2079-0325
Головна » Архiв номерiв » 2018 » Том 26, випуск 2 (95) » ПРОБЛЕМА ДИАГНОСТИКИ И ТЕРАПИИ АУТОИММУННЫХ ЭНЦЕФАЛИТОВ

ПРОБЛЕМА ДИАГНОСТИКИ И ТЕРАПИИ АУТОИММУННЫХ ЭНЦЕФАЛИТОВ

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Тип статті

  • Наукова стаття

Рубрика

  • МЕХАНІЗМИ ФОРМУВАННЯ ТА СУЧАСНІ ПРИНЦИПИ ТЕРАПІЇ НЕВРОЛОГІЧНИХ РОЗЛАДІВ

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Індекс УДК:
  • 616.831-002-07.08:612.017.1

Анотація

Аутоімунні енцефаліти (АЕ) — це неврологічне захворювання, що характеризується ураженням переважно сірої речовини, в патоґенезі якого основну роль відіграють аутоантитіла до внутрішньо- або позаклітинних структур нервової системи, які виступають як антигени. Діагностичний алгоритм, поряд з проведенням комплексного обстеження, що включає нейровізуалізацію, електроенцефалографію, дослідження цереброспінальної рідини і визначення антитіл до NMDA-рецепторів, ще треба доповнювати, в деяких випадках, пошуком і онкологічного вогнища. Терапевтичний алгоритм АЕ передбачає комбіноване призначення глюкокортикостероїдної терапії, плазмаферезу, імуноглобулінів, цитостатиків, а також — при виявленні в деяких випадках онкологічного процесу — оперативне лікування.

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  1. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma / Dalmau J., Tüzün E., Wu H. Y. [et al.] // Ann Neurol. 2007. Vol. 61, № 1. P. 25—36.
  2. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study / Titulaer M. J., McCracken L., Gabilondo I. [et al.] // Lancet Neurol. 2013. Vol. 12, № 2. P. 157—165.
  3. Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal / T. Iizuka, F. Sakai, T. Ide [et al.] // Neurology. 2008. Vol. 70, № 7. P. 504—511.
  4. Anti-N-methyl-D-aspartate receptor encephalitis in Korea: clinical features, treatment, and outcome / J. A. Lim, Lee S. T., Jung K. H. [et al.] // J Clin Neurol. 2014. Vol. 10, № 2. P. 157—161.
  5. Longitudinal electroencephalographic (EEG) findings in pediatric anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis: the Padua experience / Nosadini M., Boniver C., Zuliani L. [et al.] // J Child Neurol. 2015. Vol. 30, № 2. P. 238—245.
  6. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes / Irani S. R., Bera K., Waters P. [et al.] // Brain. 2010. Vol. 133, Pt 6. P. 1655—1667.
  7. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study // Granerod J., Ambrose H. E., Davies N. W. [et al.] // Lancet Infect Dis. 2010. Vol. 10, № 12. P. 835—844.
  8. Anti-NMDA Receptor Encephalitis: Clinical Features and Basic Mechanisms / Lynch D. R., A. Rattelle, Y. N. Dong [et al.] // Adv Pharmacol. 2018. Vol. 82. P. 235—260.
  9. Anti-NMDA receptor encephalitis presenting as an acute psychotic episode in a young woman: an underdiagnosed yet treatable disorder / S. Keller, P. Roitman, T. Ben-Hur [et al.] // Case Rep Psychiatry. 2014. Vol. 2014. P. 868325. doi: https://doi.org/10.1155/2014/868325.
  10. Burden of encephalitis-associated hospitalizations in the United States, 1998—2010 / Vora N. M., Holman R. C., Mehal J. M. [et al.] // Neurology. 2014. Vol. 82, № 5. P. 443—451.
  11. Anti-NMDAR limbic encephalitis — a clinical curiosity / A. K. Katte pur, D. Patil, A. Shankarappa [et al.] // World J Surg Oncol. 2014. Vol. 12. P. 256.
  12. Clinical experience and laboratory investigations in patients with anti NMDR encephalitis / Dalmau J., Lancaster E., MartinezHernandez E. [et al.] // Lancet Neurol. 2011. Vol. 10, № 1. P. 63—74.
  13. Paraneoplastic encephalitis, psychiatric symptoms and hypoventilation in ovarian teratoma / R. Vitaliani W. Mason, B. Ances [et al.] // Ann Neurol. 2005. Vol. 58, № 4. P. 594—604.
  14. The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project / Gable M. S., Sheriff H., Dalmau J. [et al.] // Clin Infect Dis. 2012. Vol. 54, № 7. P. 899—904.
  15. Herpes simplex encephalitis as a potential cause of antiN-methyl-D-aspartate receptor antibody encephalitis: report of 2 cases / [Desena A., Graves D., Warnack W., Greenberg B. M.] // JAMA Neurol. 2014. Vol. 71, № 3. P. 344—346.
  16. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies / Dalmau J., Gleichman A. J., Hughes E. G. [et al.] // Lancet Neurol. 2008. Vol. 7, № 12. P. 1091—1098.
  17. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents / N. R. Florance, R. L. Davis, C. Lam [et al.] // Ann Neurol. 2009. Vol. 66, № 1. P. 11—18.
  18. Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report / F. Leypoldt, M. J. Titulaer, E. Aguilar [et al.] // Neurology. 2013. Vol. 81, № 18. P. 1637—1639.
  19. A case of NMDAR encephalitis misdiagnosed as postpartum psychosis and neuroleptic malignant syndrome / Koksal A., Baybas S., Mutluay B. [et al.] // Neurol Sci. 2015. Vol. 36, № 7. P. 1257—1258.
  20. Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis / Steiner J., Walter M., Glanz W. [et al.] // JAMA Psychiatry. 2013. Vol. 70, № 3. P. 271—278.
  21. Anti-N-methyl-D-aspartate receptor encephalitis in a patient with a 7-year history of being diagnosed as schizophrenia: complexities in diagnosis and treatment / Huang C., Kang Y., Zhang B. [et al.] // Neuropsychiatr Dis Treat. 2015. Vol. 11. P. 1437—1442.
  22. Anti-NMDAR encephalitis misdiagnosed as Hashimoto’s encephalopathy / Mirabelli-Badenier M., Biancheri R., Morana G. [et al.] // Eur J Paediatr Neurol. 2014. Vol. 18, № 1. P. 72—74.
  23. Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome / [Greiner H., Leach J. L., Lee K. H., Krueger D. A.] // Seizure. 2011. Vol. 20, № 3. P. 266—270.
  24. Anti-NMDA receptor encephalitis: clinical characteristics, predictors of outcome and the knowledge gap in Southwest China / Wang W., Li J. M., Hu F. Y. [et al.] // Eur J Neurol. 2016. Vol. 23, № 3. P. 621—629.
  25. Paediatric anti-N-methyl-D-aspartate receptor encephalitis: the first Italian multicenter case series / Sartori S., Nosadini M., Cesaroni E. [et al.] // Eur J Paediatr Neurol. 2015. Vol. 19, № 4. P. 453—463.
  26. Analysis of relapses in anti-NMDAR encephalitis / Gabilondo I., Saiz A., Galán L. [et al.] // Neurology. 2011. Vol. 77, № 10. P. 996—999.
  27. Frequency and characteristics of isolated psychiatric episodes in anti-N-methyl-D-aspartate receptor encephalitis / [Kayser M. S., Titulaer M. J., Gresa-Arribas N., Dalmau J.] // JAMA Neurol. 2013. Vol. 70, № 9. P. 1133—1139.
  28. Anti-NMDA-receptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis / [Wandinger K. P., Saschenbrecker S., Stoecker W., Dalmau J.] // J Neuroimmunol. 2011. Vol. 231, № 1—2. P. 86—91.
  29. Anti-NMDAR encephalitis: a new, severe and challenging enduring entity / [E. H. van de Riet, M. M. Esseveld, L. Cuypers, J. N. Schieveld] // Eur Child Adolesc Psychiatry. 2013. Vol. 22, № 5. P. 319—323.
  30. Chapman, M. R., Vause H. E. Anti-NMDA receptor encephali tis: diagnosis, psychiatric presentation, and treatment // Am J Psychiatry. 2011. Vol. 168, № 3. P. 245—251.
  31. Anti-N-methyl-D-aspartate receptor encephalitis: a targeted review of clinical presentation, diagnosis, and approaches to psychopharmacologic management / Kruse J. L., Jeffrey J. K., Davis M. C. [et al.] // Ann Clin Psychiatry. 2014. Vol. 26, № 1. P. e1—e9.
  32. Titulaer, M. J., Dalmau J. Seizures as first symptom of antiNMDA receptor encephalitis are more common in men // Neurology. 2014. Vol. 82, № 7. P. 550—551.
  33. Pediatric anti-N-methyl-D-aspartate receptor encephalitisclinical analysis and novel findings in a series of 20 patients / Armangue T., Titulaer M. J., Málaga I. [et al.] // J Pediatr. 2013. Vol. 162, № 4. P. 850—856.e2.
  34. Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis / Viaccoz A., Desestret V., Ducray F. [et al.] // Neurology. 2014. Vol. 82, № 7. P. 556-563.
  35. Subacute anti-N-methyl-D-aspartate receptor encephalitis. A series of 13 paediatric cases / Erazo R., González J., Quintanilla C. [et al.] // Rev Chil Pediatr. 2016. Vol. 87, № 6. P. 487—493.
  36. Central neurogenic hyperventilation in anti-NMDA receptor encephalitis / [Vural A., Arsava E. M., Dericioglu N., Topcuoglu M. A.] // Intern Med. 2012. Vol. 51, № 19. P. 2789—2792.
  37. Interobserver agreement for the assessment of handicap in stroke patients / [van Swieten J. C., Koudstaal P. J., Visser M. C. [et al.] // Stroke. 1988. Vol. 19, № 5. P. 604—607.
  38. Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics / Chow F. C., Glaser C. A., Sheriff H. [et al.] // Clin Infect Dis. 2015. Vol. 60, № 9. P. 1377—1383.
  39. CNS aquaporin-4 autoimmunity in children / McKeon A., Lennon V. A., Lotze T. [et al.] // Neurology. 2008. Vol. 71, № 2. P. 93—100.
  40. Demarquay, G., Honnorat J. Clinical presentation of immunemediated cerebellar ataxia // Rev Neurol (Paris). 2011. Vol. 167, № 5. P. 408—417.
  41. Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition / Luigi Zuliani, Francesc Graus, Bruno Giometto [et al.] // J Neurol Neurosurg Psychiatry. 2012. Vol. 83, № 6. P. 638—645.
  42. Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis / Barry H., Hardiman O., Healy D. G. [et al.] // Br J Psychiatry. 2011. Vol. 199, № 6. P. 508—509.
  43. Functional and structural brain changes in anti-N-methylD-aspartate receptor encephalitis / Finke C., Kopp U. A., Scheel M. [et al.] // Ann Neurol. 2013. Vol. 74, № 2. P. 284—296.
  44. Extreme delta brush: a unique EEG pattern in adults with antiNMDA receptor encephalitis / Schmitt S. E., Pargeon K., Frechette E. S. [et al.] // Neurology. 2012. Vol. 79, № 11. P. 1094—1100.
  45. Irani, S. R., Vincent A. NMDA receptor antibody encephalitis // Curr Neurol Neurosci Rep. 2011. Vol. 11, № 3. P. 298—304.
  46. A clinical approach to diagnosis of autoimmune encephalitis / Graus F., Titulaer M. J., Balu R. [et al.] // Lancet Neurol. 2016. Vol. 15, № 4. P. 391—404.
  47. Disease-relevant autoantibodies in first episode schizophrenia / Zandi M. S., Irani S. R., Lang B. [et al.] // J Neurol. 2011. Vol. 258, № 4. P. 686—688.
  48. Antiepileptic treatment for anti-NMDA receptor encephalitis: the need for video-EEG monitoring / Dericioglu N., Vural A., Acar P. [et al.] // Epileptic Disord. 2013. Vol. 15, № 2. P. 166—170.
  49. Clinical Neuropathology practice guide 4-2013: post-herpes simplex encephalitis: N-methyl-D-aspartate receptor antibodies are part of the problem / Romana Höftberger, Thaís Armangue, Frank Leypoldt [et al.] // Clin Neuropathol. 2013. Vol. 32, № 4. P. 251—254.
  50. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium / Venkatesan A., Tunkel A. R., Bloch K. C. [et al.] // Clin Infect Dis. 2013. Vol. 57, № 8. P. 1114—1128.
  51. Overlapping demyelinating syndromes and anti-N-methylD-aspartate receptor encephalitis / Titulaer M. J., Höftberger R., Iizuka T. [et al.] // Ann Neurol. 2014. Vol. 75, № 3. P. 411—428.
  52. Anti-N-methyl-D-aspartate receptor encephalitis with acute disseminated encephalomyelitis-like MRI features / Lekoubou A., Viaccoz A., Didelot A. [et al.] // Eur J Neurol. 2012. Vol. 19, № 2. P. e16—e17.
  53. Anti-N-methyl-D-aspartate receptor encephalitis in a patient with neuromyelitis optica spectrum disorders / Luo J. J., Lv H., Sun W. [et al.] // Mult Scler Relat Disord. 2016. Vol. 8. P. 74—77.
  54. NMDA receptor encephalitis mimicking seronegative neuromyelitis optica / M. C. Kruer, T. K. Koch, D. N. Bourdette [et al.] // Neurology. 2010. Vol. 74, № 18. P. 1473—1475.
  55. N-methyl D-aspartate receptor antibody encephalitis associated with myelitis / C. Pennington, S. J. Livingstone, S. Razvi [et al.] // J Neurol Sci. 2012. Vol. 317, № 1—2. P. 151—153.
  56. A case of anti-N-methyl-D-aspartate receptor encephalitis with multiple sclerosis-like demyelinated lesions / Takeda A., Shimada H., Tamura A. [et al.] // Mult Scler Relat Disord. 2014. Vol. 3, № 3. P. 391—397.
  57. Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort / Hacohen, Y., Absoud, M., Woodhall, M. [et al.] // J Neurol Neurosurg Psychiatry. 2014. Vol. 85, № 4. P. 456—461.
  58. Mann, A. P., Grebenciucova E., Lukas R. V. Anti-N-methyl-Daspartate-receptor encephalitis: diagnosis, optimal management, and challenges // Ther Clin Risk Manag. 2014. Vol. 10. P. 517—525.
  59. Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis / Seki M., Suzuki S., Iizuka T. [et al.] // J Neurol Neurosurg Psychiatry. 2008. Vol. 79, № 3. P. 324—326.
  60. Anti-N-methyl-D-aspartate receptor encephalitis associated with an ovarian teratoma in an adolescent female / Lesher A. P., Myers T. J., Tecklenburg F. [et al.] // J Pediatr Surg. 2010. Vol. 45, № 7. P. 1550—1553.
  61. Refractory status epilepticus caused by anti-NMDA receptor encephalitis that markedly improved following combination therapy with rituximab and cyclophosphamide / Kadoya M., Onoue H., Kadoya A. [et al.] // Intern Med. 2015. Vol. 54, № 2. P. 209—213.
  62. Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab / Ishiura H., Matsuda S., Higashihara M. [et al.] // Neurology. 2008. Vol. 71, № 23. P. 1921—1923.
  63. Screening for tumors in paraneoplastic syndromes: report of an EFNS task force / Titulaer M. J., Soffietti R., Dalmau J. [et al.] // Eur J Neurol. 2011. Vol. 18, № 1. P. 19—e3.
  64. Anti-NMDA receptor encephalitis in children: the disorder, its diagnosis, and treatment / Peery H. E., Day G. S., Doja A. [et al.] // Handb Clin Neurol. 2013. Vol. 112. P. 1229—1233.
  65. A multidisciplinary approach to the treatment of anti-NMDAreceptor antibody encephalitis: a case and review of the literature / Mann A., Machado N. M., Liu N. [et al.] // J Neuropsychiatry Clin Neurosci. 2012. Vol. 24, № 2. P. 247—254.
  66. The rehabilitation of children with anti-N-methyl-D-aspartatereceptor encephalitis: a case series / Houtrow A. J., Bhandal M., Pratini N. R. [et al.] // Am J Phys Med Rehabil. 2012. Vol. 91, № 5. P. 435—441.
  67. Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study / T. Iizuka, S. Yoshii, S. Kan [et al.] // J Neurol. 2010. Vol. 257, № 10. P. 1686—1691.
  68. Antibody titers at diagnosis and during follow-up of antiNMDA receptor encephalitis: a retrospective study / Gresa-Arribas N., Titulaer M. J., Torrents A. [et al.] // Lancet Neurology. 2014. Vol. 13, № 2. P. 167—177.
  69. Late-onset anti-NMDA receptor encephalitis / Titulaer M. J., McCracken L., Gabilondo I. [et al.] // Neurology. 2013. Vol. 81, № 12. P. 1058—1063.

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