ГоловнаArchive of numbers2017Volume 25, issue 2 (91)Prediction of the severity of myasthenia gravis depending on the structural changes of the thymus
Title of the article Prediction of the severity of myasthenia gravis depending on the structural changes of the thymus
Authors Samoilova Hanna
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL DISORDERS
Year 2017 Issue Volume 25, issue 2 (91) Pages 28-30
Type of article Scientific article Index UDK 616.831.8-009.17:616.438:53.083.3 Index BBK -
Abstract The results of clinical and immunological examination of 102 patients with myasthenia gravis have been analyzed. Was found that the thymus structure changes aff ect the severity of the disease according to the indicators of QMG scale (the most severe course was in patients with myasthenia gravis+ thymoma, the easiest — in patients without structural changes in the thymus). For patients with myasthenia gravis without structural changes of thymus criteria of the disease severity are: reduction of phagocytic index, inhibition of expression of CD8+ expression and increased CD50+ and CD54+. For patients with myasthenia + thymic hyperplasia criteria of the disease severity are: inhibition of expression of CD8+, and increased expression of CD16+, CD50+ and CD54+. For patients with myasthenia+ thymoma inhibition of: reduction of phagocytic index, inhibition of expression of CD11a+, increased expression of CD11b+, CD16+, CD19+, CD50+ and CD54+.
Key words myasthenia gravis, the thymus hyperplasia, thymoma, immunological imbalance
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