ГоловнаArchive of numbers2017Volume 25, issue 2 (91)Possibilities of using the fi nding of serum level of neuronspecifi c enolase as for prediction the level of neurological defi cit in early recovery period of cerebral ischemic hemispheric stroke
Title of the article Possibilities of using the fi nding of serum level of neuronspecifi c enolase as for prediction the level of neurological defi cit in early recovery period of cerebral ischemic hemispheric stroke
Authors Medvedkova Svitlana
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL DISORDERS
Year 2017 Issue Volume 25, issue 2 (91) Pages 23-26
Type of article Scientific article Index UDK 616.831-005.1-005.4-036.1-074:577.15]-037 Index BBK -
Abstract The aim is to value the diagnostic informative basis of serum concentration of neuron-specific enolase (NSE) on the 10th day of disease of cerebral ischemic hemispheric stroke (CIHS) as for prediction of the level of neurological defi cit in early recovery period of the disease. Materials and methods: complex clinical and instrumental-laboratory research was done among 72 patients (the average age of patients was 57.4 ± 1.2 years) in early recovery period of CHIS using National Institute of Health Stroke Scale (NIHSS), Barthel Index, modifi ed Rankin Scale on the 10th, 30th, 90th and 180th day of disease, computed tomography scan of cerebrum. The level of neuron-specifi c enolase in the blood serum was defi ned on the 10th day of disease. ROC-analysis was used as for identifi cation the criteria of prediction. It was defi ned that; those patients with CIHS whose results according to the scale NIHSS on the 180 day of CIHS were 5 points and more, on the 10th day of disease differed by the higher serum level of NSE in comparison with those patients, whose results as for the NIHSS on the 180th day of CIHS were less than 5 points (3,86 [3.25; 4.57] mkg/l against 1.51 [0.56; 2.36] mkg/l, р = 0.029). The serum concentration of neuron-specifi c enolase on the 10th day was associated with the level of neurological defi cit on the 180th day of disease (R = +0.29, p < 0.05); the serum concentration of neuron-specifi c enolase on the 10th day is associated with the level of neurological defi cit on the 180 day (R = +0.29, p < 0.05); the predictor of grade as for NIHSS scale 5 points and more on the 90th and on the 180 day of disease of CIHS is the levels of neuron-specifi c enolase in the blood serum more 2.95 mcg/L on the 10th day of disease (AUC = 0.81, p < 0.05; sensitivity is equal to 80.0 %, specifi city — 82.3 %).
Key words cerebral ischemic hemispheric stroke, neuron-specifi c enolase, prediction
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