Title of the article Burden of cerebral small vessel disease
Authors Mishchenko Tamara
Nikishkova Iryna
Mishchenko Vladyslav
Kutikov Damir
In the section PROBLEMATIC ARTICLES
Year 2016 Issue Volume 24, issue 3 (88) Pages 11-16
Type of article Scientific article Index UDK 616.831-005-036.87 Index BBK -
Abstract The article is devoted to a retrospective cohort study of assessment of cerebral small vessel disease (сSVD) score according to the scale of total сSVD burden. In accordance with neuroimaging data, in 308 patients with сSVD scores of the burden of the disea se was 0 in 107 patients (34.74 %), 1 in 71 (23.05 %) (p < 0.001), 2 in 66 (21.43 %), 3 in 44 (14.29 %) (p < 0.01), and 4 in 20 ones (6.49 %) (p < 0.001). Among MRI markers of сSVD the most prevalent were visible perivascular spaces (93.5 %) and leucoaraiosis (62.7 %). An amount of silent brain infarcts was 50 % of cases (p < 0.0001) and of cerebral microbleedings was 16.2 % (p < 0.0001). An asso ciation between score of the сSVD burden and 6 vascular risk factors (arterial hypertension (AH), carotid stenosis, dyslipidemia, diabetes mellitus II, sleep apnea, and gender) have been found. AH was associated with the сSVD burden independently from a total сSVD score, and connections between the сSVD burden and other 5 vascular risk factors were of a complicated character. An increasing of total сSVD score also did not come down to a linear growth of number of all the MRI markers of the disease and was not connected with age of the patients. It is the simultaneous increasing of severity/number of asymptomatic lesions up to a critical level due to a step-by-step character of their accumulation in сSVD might be morphofunctional background for a crashing character of symptomatic stroke, cognitive decline, and vascular dementia.
Key words cerebral small vessel disease, burden, MRI markers, prevalence, vascular risk factors, visible perivascular space, leucoaraiosis, silent brain infarct, cerebral microbleeding
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