ГоловнаArchive of numbers2016Volume 24, issue 2 (87)Аpoptosis of peripheral blood leukocytes in patients with traumatic brain injury consequences
Title of the article Аpoptosis of peripheral blood leukocytes in patients with traumatic brain injury consequences
Authors Salii Zoia
Shkrobot Svitlana
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL DISORDERS
Year 2016 Issue Volume 24, issue 2 (87) Pages 23-27
Type of article Scientific article Index UDK 616.833.1-001.1-009.11 Index BBK -
Abstract The aim of this study was to establish main peculiarities of apoptosis of peripheral blood leukocytes in patients with traumatic brain injury consequences of varying severity. In 280 patients with the eff ects of light (95), moderate (72) and hard (113) TBI and the catamnesis of trauma in the age from 1 to 30 years percentage of peripheral blood leukocytes in stage of apoptosis (AnV+) and necrotic (PI+) was explored by fl ow cytofl uorometry method. The control group consisted of 30 people representative by age and sex. Neurological status was assessed by Neurological Outcome Scale for Traumatic Brain Injury (NOS-TBI), cognitive status — Montreal scale for cognitive defi cit (MoСА), the level of anxiety and depression — by the HADS scale. Activation of necrosis and apoptosis of peripheral blood leukocytes was diagnosed in patients of the main group. Credible dependency of these data on gender, case history, severity of injury and presence of concomitant somatic pathology was not defi ned. There was no significant difference between РІ+ and AnV+ values in patients of diff erent age groups. However, with age, negative relationship between AnV+ and MoСА test amplifi ed. Increased depressive disorder (HADS scale) was also combined with activation of necrosis and apoptosis of peripheral blood leukocytes.
Key words traumatic brain injury consequences, apoptosis, peripheral blood leukocytes
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