ГоловнаArchive of numbers2016Volume 24, issue 1 (86)Dynamics of leptinlevel and production of interleukin-1 by mononuclear blood cells in patients with epilepsy under different conditions of treatment
Title of the article Dynamics of leptinlevel and production of interleukin-1 by mononuclear blood cells in patients with epilepsy under different conditions of treatment
Authors Muratova Tetiana
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL DISORDERS
Year 2016 Issue Volume 24, issue 1 (86) Pages 41-44
Type of article Scientific article Index UDK 616.12-008.331.1 Index BBK -
Abstract The level of leptin in blood serum in patients with complex partial epilepsy with secondarily developed generalized seizures exceeded that one registered before transcranial magnetic stimulation (TMS) of cerebellum by 41.5 % (P < 0.05). The number of blood mononuclearcells transformed into blast cells, which was the marker for ability to produce interleukine-1, and which was determined in epileptic patients under conditions of incubation of blood mononuclears with bacterial lipopolysaccharide during 1.5 hour exceeded that one in practically health persons by 4.1 times (rised up to 235.7 ± 21.6 % from 57.2 ± 4.9 % in control, P < 0.05). The treatment with levetiracetam (three weeks), nicotinamid (one week) and TMS caused signifi cant decrease the number of blast cells under condition of 1.5 hour incubation; their number was less when compared with such one in group treated with levetiracetam during four weeks combined with nicotinamid (two weeks) (P < 0.05).
Key words epilepsy, immunological reactivity, leptin, transcranial magnetic stimulation, levetiracetam, nicotinamid
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