ГоловнаArchive of numbers2013Volume 21, issue 3 (76)Dopaminergic disbalance, salience dysregulation and reward system in schizophrenia: a report on symposium held on April 8, 2013 at XXI EPA Congress (6—9 April, 2013, Nice, France)
Title of the article Dopaminergic disbalance, salience dysregulation and reward system in schizophrenia: a report on symposium held on April 8, 2013 at XXI EPA Congress (6—9 April, 2013, Nice, France)
Authors Alfimov P.
In the section COUNCIL OF YOUNG SCIENTISTS
Year 2013 Issue Volume 21, issue 3 (76) Pages 162-169
Type of article Scientific article Index UDK 616.89; ГРНТИ 76.29.52; ВАК 14.01.06 Index BBK -
Abstract This paper provides an overview of the symposium Reward, Salience and Dopamine in Schizophrenia Patients, which was held on April 8, 2013 under the chairmanship of A. Heinz (Germany), and O. Howes (UK) during the XXI Congress of the European Psychiatric Association (6—9 April 2013, Nice, France). This paper provides a brief review of key defi nitions, reports of four in dependent research groups from diff erent regions of Europe and relevant publications on dopaminergic dysbalance, neuroimaging fi ndings, salience disruption and signal processing in the reward system which occur in schizophrenia patients.
Key words schizophrenia, salience, reward processing, dopaminergic transmission, neuroimaging, ventral striatum, EPA Congress 2013.
Access to full text version of the article pdf download
Bibliography 1. Мосолов С. Н. Некоторые актуальные теоретические проблемы диагностики, классификации, нейробиологии и терапии шизофрении: сравнение зарубежного и отечественного подходов / С. Н. Мосолов // Журнал неврологии и психиатрии им. С. С. Корсакова. — 2010. — № 6. — С. 4—11.
2. Abler B. Neural correlates of frustration / Abler B., Walter H., Erk S. / Neuroreport. — 2005. — 7: Vol. 16. — P. 669—672.
3. Berridge K. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? / K. Berridge, T. Robinson // Brain Research Reviews. — 1998. — 3: Vol. 28. — P. 309—369.
4. Heinz A. Dopaminergic dysfunction in alcoholism and schizophrenia — psychopathological and behavioral correlates / A. Heinz // Eur Psychiatry. — 2002. — 1: Vol. 17. — P. 9—16.
5. Molecular Brain Imaging and the Neurobiology and Genetics of Schizophrenia / [Heinz A., Romero B., Gallinat J. et al.] // Pharmacopsychiatry. — 2003. — Suppl 3: Vol. 36. — P. 152—157.
6. Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study / [Howes O., Bose S., Turkheimer F. et al.] // Molecular Psychiatry. — 2011. — 9: Vol. 16. — P. 885—886. 7. The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment: Meta-analysis of Imaging Studies / [Howes O., Kambeitz J., Kim E. et al.] // Arch Gen Psychiatry. — 2012. — 8: Vol. 69. — P. 776—786.
8. Dysfunction of ventral striatal reward prediction in schizo phrenic patients treated with typical, not atypical, neuroleptics / [Juckel G., Schlagenhauf F., Koslowski M. et al.] // Psychopharmacology. — 2006b. — 2: Vol. 187. — P. 222—228.
9. Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics / [Juckel G. Schlagenhauf F., Koslowski M. et al.] // Ibid. — 2006a. — 2: Vol. 187. — P. 222—228.
10. Dysfunction of ventral striatal reward prediction in schizophrenia / [Juckel G., Schlagenhauf F., Koslowski M. et al.] // Neuroimage. — 2006b. — 2: Vol. 29. — P. 409—416.
11. Kapur S. Psychosis as a State of Aberrant Salience: A Framework Linking Biology, Phenomenology, and Pharmacology in Schizophrenia / S. Kapur // Am J Psychiatry. — 2003. — 1: Vol. 160. — P. 13—23.
12. Anticipation of increasing monetary reward selectively recruits nucleus accumbens / [Knutson B., Adams C., Fong G., Hommer D.] // J Neurosci. — 2001. — 16: Vol. 21. — P. 1—5.
13. Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia / [Nielsen M., Rostrup E., Wulff S. et al.] / Arch Gen Psychiatry. — 2012b. — 12: Vol. 69. — P. 1195—1204.
14. Alterations of the brain reward system in antipsychotic naïve schizophrenia patients / [Nielsen M., Rostrup E., Wulff S. et al.] // Biol Psychiatry. — 2012a. — Vol. 71. — 10. — P. 898—905.
15. Robinson T. The neural basis of drug craving: an incentivesensitization theory of addiction / T. Robinson, K. Berridge // Brain Res Brain Res Rev. — 1993. — 3: Vol. 18. — P. 247—291.
16. Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine / [Schlagenhauf F., Juckel G., Koslowski M. et al.] // Psychopharmacology. — 2008. — 4: Vol. 196. — P. 673—684.
17. Schultz W. A neural substrate of prediction and reward / Schultz W., Dayan P., Montague P. // Science. — 1997. — Vol. 275. — P. 1593—1599.
18. Neural correlates of reward processing in schizophrenia — Relationship to apathy and depression / [Simon J., Biller A., Walther S. et al.] // Schizophrenia Research. — 2010. — Vol. 118. — P. 154—161.
19. Jim van Os J. A salience dysregulation syndrome / J. Jim van Os // Br J Psychiatry. — 2009. — 2: Vol. 194. — P. 101—103.
20. Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers / [Waltz J., Schweitzer J., Gold J. et al.] / Neuropsychopharmacology. — 2008. — 6: Vol. 34. — P. 1567—1577.