ГоловнаArchive of numbers2023Volume 31, issue 4(117)The study of relationships between clinical syndromes and gene polymorphisms of ACE and AT2R1 genes in patients with chronic vascular encephalopathy.
Title of the article The study of relationships between clinical syndromes and gene polymorphisms of ACE and AT2R1 genes in patients with chronic vascular encephalopathy.
Authors Duve Khrystyna
In the section MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS
Year 2023 Issue Volume 31, issue 4(117) Pages 5-10
Type of article Scientific article Index UDK 616.831:575.174.015.3 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V31-is4-2023-1

This article presents the results of the study of relationships between clinical presentation and polymorphism of the ACE and AT2R1 genes in patients with chronic vascular encephalopathy (CVE). The 145 patients with chronic vascular encephalopathy (CVE) were examined in order to analyze the clinical presentation of the disease. The molecular genetic research was performed in 18 patients. After the complete clinical and neurological examination, such frequency of the syndromes was found: cephalalgic (70.34 %), extrapyramidal (60.00 %), vestibular (61.38 %), asthenic (53.79 %) syndromes, and syndrome of cognitive disorders (66.21 %). When assessing the dependence of the clinical syndromes most often found in patients with CVE on the I/D polymorphism of the ACE gene, it was established that 90.91 % of patients with cephalalgic syndrome, 81.82 % of patients with asthenic syndrome, and 90.91 % of patients with extrapyramidal syndrome are carriers of the D/D genotype. In contrast, all patients with the absence of cephalalgic, extrapyramidal, and asthenic syndromes had the I/I ACE gene genotype. No significant correlations were found between the presence/absence of clinical syndromes and the frequency distribution of genotypes and alleles of the A1166C polymorphic variant of the AT2R1 gene in patients with CVE.
Key words encephalopathy, ACE gene polymorphism, AT2R1 gene polymorphism, vascular encephalopathy, chronic brain ischemia
Access to full text version of the article pdf download
Bibliography 1. Pashkovskaya N. V. Diabeticheskiye entsefalopatii: mekhanizm razvitiya, differentsialnaya diagnostika, lecheniye i profilaktika [Diabetic encephalopathies: mechanism of development, differential diagnosis, treatment and prevention] : avtoref. dis. ... d-ra med. nauk : spets. 14.01.11 — Nervnyye zabolevaniya [Dissertation abstract for obtaining the scientific degree of Doctor of Medical Sciences. 14.01.15 — nervous diseases] / N. V. Pashkovskaya ; Bukovinskiy gosudarstvennyy meditsinskiy universitet MOZ Ukrainy. Kharkov, 2010. 25 s. (In Russian).
2. Mushehian M. M., Litovchenko T. A., Voitiuk A. O. Otsinka klinichnykh pokaznykiv khvorykh na symptomatychnu sudynnu epilepsiiu z khronichnymy porushenniamy mozkovoho krovoobihu. [Evaluation of clinical parameters in patients with symptomatic vascular epilepsy and chronic disorders of cerebral circulation]. Mizhnarodnyi nevrolohichnyi zhurnal. [International neurological journal]. 2019. 4 (106), 26–32. https://doi. org/10.22141/2224-0713.4.106.2019.174048. (In Ukrainian).
3. Petrenko M. S., Hrabovetskyi S. A. Analiz zviazku kontsentratsii zaliza v bazalnykh yadrakh iz kohnityvnymy porushenniamy u khvorykh na hipertenzyvnu ta aterosklerotychnu entsefalopatiiu pry doslidzhennia zmin mahnitnoi spryiniatlyvosti pidkirkovykh struktur holovnoho mozku. Skhidno-yevropeiskyi nevrolohichnyi zhurnal [East European Journal of Neurology]. 2018; 3: 19-25. http://nbuv.gov.ua/UJRN/cenj_2018_3_5. (In Ukrainian).
4. Vladimirskiy E. V., Karakulova Yu. V., & Tsepilov S. V. Dinamika pokazateley kognitivnoy sfery i neyrotroficheskikh faktorov v protsesse balneoterapii pri distsirkulyatornoy entsefalopatii. [Dynamics of the cognitive sphere indicators and neurotrophic factors in the course of balneotherapy of dyscirculatory encephalopathy]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kultury [Questions of spa treatment, physiotherapy and therapeutic physical culture]. 2019. 96(2). 4—10. https:// doi.org/10.17116/kurort2019960214. (In Russian).
5. Parfenov V. A., Zhivolupov S. A., Zakharov V. V., Belova L. A. Khronicheskiye tserebrovaskulyarnyye zabolevaniya: primeneniye vinpotsetina v nevrologicheskoy praktike (materialy Kruglogo stola) [Chronic cerebrovascular diseases: use of vinpocetin in neurological practice (Round Table discussion)]. Nevrologiya, neyropsikhiatriya, psikhosomatika [Neurology, neuropsychiatry, psychosomatics]. 2018. 10 (4). 139-145. DOI: 10.14412/2074- 2711-2018-4-139-145. (In Russian).
6. Verjugina NI, Chimagomedova ASh, Starovoitova IM, Levin OS. Éndotelial’naia disfunktsiia pri distsirkuliatornoĭ éntsefalopatii [Endothelial dysfunction in chronic vascular encephalopathy]. Zhurnal nevrologii i psikhiatrii im S S Korsakova. 2017;117(6. Vyp. 2):73-80. doi: 10.17116/jnevro20171176273-80. PMID: 28980617. (In Russian).
7. Gurol ME, Sacco RL, McCullough LD. Multiple Faces of Cerebral Small Vessel Diseases. Stroke. 2020 Jan;51(1):9-11. doi: 10.1161/STROKEAHA.119.027969. Epub 2019 Nov 22. PMID: 31752615; PMCID: PMC7590926.
8. Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, Gulati M, Kamel H, Knopman DS, Launer LJ, Saczynski JS, Seshadri S, Zeki Al Hazzouri A; American Heart Association Council on Hypertension; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council. Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension. 2016 Dec;68(6):e67-e94. doi: 10.1161/HYP.0000000000000053. Epub 2016 Oct 10. PMID: 27977393; PMCID: PMC5361411.
9. Walker KA, Power MC, Gottesman RF. Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review. Curr Hypertens Rep. 2017 Mar;19(3):24. doi: 10.1007/ s11906-017-0724-3. PMID: 28299725; PMCID: PMC6164165.
10. Peila R, White LR, Petrovich H, Masaki K, Ross GW, Havlik RJ, Launer LJ. Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the HonoluluAsia Aging Study. Stroke. 2001 Dec 1;32(12):2882-9. doi: 10.1161/ hs1201.100392. PMID: 11739991.
11. de Leeuw FE, Richard F, de Groot JC, van Duijn CM, Hofman A, Van Gijn J., Breteler MM. Interaction between hypertension, apoE, and cerebral white matter lesions. Stroke. 2004 May;35(5):1057-60. doi: 10.1161/01.STR.0000125859.71051.83. Epub 2004 Apr 1. PMID: 15060316. 12. Andrews S, Das D, Anstey KJ, Easteal S. Interactive effect of APOE genotype and blood pressure on cognitive decline: the PATH through life study. J Alzheimers Dis. 2015;44(4):1087- 98. doi: 10.3233/JAD-140630. PMID: 25672766.
13. de Frias CM, Schaie KW, Willis SL. Hypertension moderates the effect of APOE on 21-year cognitive trajectories. Psychol Aging. 2014 Jun;29(2):431-9. doi: 10.1037/a0036828. PMID: 24956008. 14. O’Donell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, Myers RH, Levy D. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation. 1998 May 12;97(18):1766-72. doi: 10.1161/01.cir.97.18.1766. PMID: 9603529.
15. Sierra C, Coca A, Gómez-Angelats E, Poch E, Sobrino J, de la Sierra A. Renin-angiotensin system genetic polymorphisms and cerebral white matter lesions in essential hypertension. Hypertension. 2002 Feb;39(2 Pt 2):343-7. doi: 10.1161/ hy02t2.102912. PMID: 11882570.
16. Wan, C., Zong, R. Y., & Chen, X. S. The new mechanism of cognitive decline induced by hypertension: High homocysteine- mediated aberrant DNA methylation. Front Cardiovasc Med. 2022 Oct 24;9:928701. doi: 10.3389/fcvm.2022.928701. PMID: 36352848; PMCID: PMC9637555.
17. McHugh J. ACE inhibitors preserve cognitive function. Nat Rev Rheumatol. 2018 Nov;14(11):623. doi: 10.1038/s41584- 018-0102-9. PMID: 30310160.
18. Li Y, Zhang Z, Deng L, Bai F, Shi Y, Yu H, Xie C, Yuan Y, Zhang Z. Genetic variation in angiotensin converting-enzyme affects the white matter integrity and cognitive function of amnestic mild cognitive impairment patients. J Neurol Sci. 2017 Sep 15;380:177-181. doi: 10.1016/j.jns.2017.06.026. Epub 2017 Jun 16. PMID: 28870562.
19. Zhang Z, Deng L, Bai F, Shi Y, Yu H, Yuan Y, Jiang T, Jia J, Zhang Z. ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment. Behav Brain Res. 2011 Mar 17;218(1):114-20. doi: 10.1016/j. bbr.2010.11.032. Epub 2010 Nov 23. PMID: 21108975.
20. Taylor WD, Benjamin S, McQuoid DR, Payne ME, Krishnan RR, MacFall JR, Ashley-Koch A. AGTR1 gene variation: association with depression and frontotemporal morphology. Psychiatry Res. 2012 May 31;202(2):104-9. doi: 10.1016/j. pscychresns.2012.03.007. Epub 2012 Jun 15. PMID: 22703619; PMCID: PMC3398195.
21. Zannas AS, McQuoid DR, Payne ME, MacFall JR, Ashley- Koch A, Steffens DC, Potter GG, Taylor WD. Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. Am J Psychiatry. 2014 Nov 1;171(11):1214-21. doi: 10.1176/appi. ajp.2014.13111543. PMID: 25124854; PMCID: PMC4329281.