ГоловнаArchive of numbers2016Volume 24, issue 4 (89)Neuroanatomical and histological background of schizophrenia (review)
Title of the article Neuroanatomical and histological background of schizophrenia (review)
Authors Osokina Olga
Year 2016 Issue Volume 24, issue 4 (89) Pages 72-75
Type of article Scientific article Index UDK 616.895.8-008:611.8(048.8) Index BBK -
Abstract We carried out a review of the morphological features of the brain in schizophrenia patients in this article. Carried out morphometric studies have shown a reduction of the gray matter volume of the brain in patients with schizophrenia. Parts of researches were also found the reduction of white matter of the brain. It is proved that structurally and functionally the most expressed changes are in the frontal, temporal lobe (more on the left) and the limbic system (in particular, the hippocampus). The electron microscopy of pyramidal layer of hippocampus in schizophrenia was showed the pathology of oligodendrogliocytes and myelinated axons. This may be the cause of cognitive weaknesses and indicates that a impairment of the ontogenetic development of the individual regarding the myelination process in the brain refl ects the likely role in the pathogenesis of schizophrenia.
Key words schizophrenia, gray and white matter of the brain, oligodendrogliocytes, myelinated axons
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