ГоловнаArchive of numbers2023Volume 31, issue 3 (116)Neuroethological analysis of the features of aggressive and submissive behavior of rats with alcohol dependence during the action of intranasally administered progesterone
Title of the article Neuroethological analysis of the features of aggressive and submissive behavior of rats with alcohol dependence during the action of intranasally administered progesterone
Authors Berchenko Olga
Veselovska Olena
Shlyakhova Anna
In the section DIAGNOSTICS AND THERAPY OF MENTAL AND BEHAVIORAL DISORDERS
Year 2023 Issue Volume 31, issue 3 (116) Pages 59-65
Type of article Scientific article Index UDK 612.820:616-092.9-89 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V31-is3-2023-10

 The aim of the work was to study in a chronic experiment the effect of intranasal progesterone administration on the specifics of behavioral (aggressive and submissive) reactions of rats with alcohol dependence during agonistic encounters. It was shown that the intranasal administration of progesterone to aggressive rats with alcohol dependence under conditions of long-term psychoemotional consequences of zoosocial confrontational interactions led to a decrease in aggressive motivational reactions (the number and total time of attacks); rats with a subordinate type of behavior with alcohol addiction — to a decrease in quantitative and time indicators of passive-defensive behavior. The features of the anxiolytic and hypnotic effects of progesterone on the emotional behavior of aggressive and submissive rats with alcohol dependence were revealed.
Key words alcohol dependence, intranasal administration of progesterone, agonistic collisions
Access to full text version of the article pdf download
Bibliography 1. Miczek KA, DeBold JF, Hwa LS, Newman EL, de Almeida RM. Alcohol and violence: neuropeptidergic modulation of monoamine systems. Ann N Y Acad Sci. 2015 Sep;1349(1):96-118. doi: 10.1111/nyas.12862. Epub 2015 Aug 18. PMID: 26285061; PMCID: PMC4564371.
2. Heinz AJ, Beck A, Meyer-Lindenberg A, Sterzer P, Heinz A. Cognitive and neurobiological mechanisms of alcohol-related aggression. Nat Rev Neurosci. 2011 Jun 2;12(7):400-13. doi: 10.1038/nrn3042. PMID: 21633380.
3. Sontate KV, Rahim Kamaluddin M, Naina Mohamed I, Mohamed RMP, Shaikh MF, Kamal H, Kumar J. Alcohol, Aggression, and Violence: From Public Health to Neuroscience. Front Psychol. 2021 Dec 20;12:699726. doi: 10.3389/fpsyg.2021.699726. PMID: 35002823; PMCID: PMC8729263.
4. Veselovska, O. V., Shlyakhova A. V., Levicheva N. O., Bevziuk D. O., Berchenko O. H., Prikhodko O. O. Realizatsiia tryvozhnosti i ahresyvnosti u shchuriv z alkoholnoiu zalezhnistiu v umovakh zoosotsialnoho konfliktu. Fiziolohichnyi zhurnal. [Physiological journal]. 2022. 68 (4). S. 66—76. https://doi. org/10.15407/fz68.04.066. (In Ukrainian).
5. Jie F, Yin G, Yang W, Yang M, Gao S, Lv J, Li B. Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases. Front Neurosci. 2018 Aug 14;12:562. doi: 10.3389/fnins.2018.00562. PMID: 30154693; PMCID: PMC6103381.
6. Koob G. F. A role for GABA mechanisms in the motivational effects of alcohol. Biochem. Pharmacol. 2004 Oct 15;68(8):1515- 25. doi: 10.1016/j.bcp.2004.07.031. PMID: 15451394.
7. Abrahao KP, Salinas AG, Lovinger DM. Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits. Neuron. 2017 Dec 20;96(6):1223-1238. doi: 10.1016/j.neuron.2017.10.032. PMID: 29268093; PMCID: PMC6566861.
8. Berchenko O. H., Tytkova A. M., Shlyakhova A. V., Veselovska O. V., Prikhodko O. O. Osoblyvosti neirorehuliatornykh mekhanizmiv adaptatsii pry alkoholnii zalezhnosti (eksperymentalne doslidzhennia). Ukrainskyi visnyk psykhonevrolohii. 2021. Vol. 29, issue 2 (107). S. 36—40. DOI: https://doi. org/10.36927/2079-0325-V29-is2-2021-6. (In Ukrainian).
9. Zheng P. Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Prog Neurobiol. 2009. Oct;89(2). P. 134 — 52. doi: 10.1016/j. pneurobio.2009.07.001. Epub 2009 Jul 10. PMID: 19595736.
10. Balashov, A. M. Neyrosteroidy pri addiktivnoy patologii. Zhurnal nevrologii i psikhiatrii imeni S. S. Korsakova. 2010. 110 (6). S. 107-111. (In Russian).
11. Ducharme N, Banks WA, Morley JE, Robinson SM, Niehoff ML, Mattern C, Farr SA. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2- 3):128-34. doi: 10.1016/j.ejphar.2010.05.033. Epub 2010 Jun 8. Erratum in: Eur J Pharmacol. 2010 Nov 10;646(1-3):46. Farr, Susan A [added]. PMID: 20570588; PMCID: PMC3008321.
12. Peltier MR, Sofuoglu M. The role of exogenous progesterone in the treatment of males and females with substance use disorders: a narrative review. CNS Drugs. 2018 May; 32 (5). P. 421—435. doi: 10.1007/s40263-018-0525-5. PMID: 29761343; PMCID: PMC6235727.
13. Titkova, A., Berchenko, O., Shlyakhova, A., Veselovskaya, E., & Prikhodko, E. Vzaimodeystviya dofamina, oksida azota i testosterona v mozgovoy sisteme motivatsionnogo podkrepleniya krys s alkogolnoy zavisimostyu i pod vliyaniyem donatora oksida azota [Interaction of dopamine, nitric oxide and testosterone in the brain system of motivational reinforcement in rats with alcohol dependence and under nitric oxide donator impact]. Visnyk Kharkivskoho natsionalnoho universytetu imeni V. N. Karazina [The Journal of V. N. Karazin's Kharkiv National University]. Series "Biology", 30(30), 95—102. https://doi.org/10.26565/2075-5457-2018-30-11. (In Russian).
14. Erdő F, Bors LA, Farkas D, Bajza Á, Gizurarson S. Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Res Bull. 2018 Oct;143:155-170. doi: 10.1016/j. brainresbull.2018.10.009. Epub 2018 Oct 25. PMID: 30449731.
15. Didone, Vincent & Masson, Sébastien & Quoilin, Caroline & Seutin, Vincent & Quertemont, Etienne. (2015). Correlation between ethanol behavioral sensitization and midbrain dopamine neuron reactivity to ethanol. Addiction Biology. 21 (2). doi: https://doi.org/10.1111/adb.12216.
16. Denson, T. F., Kasumovic, M. M., & Harmon-Jones, E. (2022). Understanding the desire to play violent video games: An integrative motivational theory. Motivation Science, 8(2), 161–173. https://doi.org/10.1037/mot0000246.