ГоловнаArchive of numbers2023Volume 31, issue 2 (115)The problem of profile and duration of cognitive impairments associated with COVID-19 (literature review)
Title of the article The problem of profile and duration of cognitive impairments associated with COVID-19 (literature review)
Authors Nikishkova Iryna
In the section LITERATURE REVIEW
Year 2023 Issue Volume 31, issue 2 (115) Pages 98-104
Type of article Scientific article Index UDK 616.89-008.46:616.89-008.47:616.9-079 Index BBK -
Abstract

 The article provides a review of results of researches, systematic reviews and meta-analyses dealt with peculiarities of cognitive impairments (profile, prevalence, duration) and methodological approaches to their detection in persons after coronavirus disease 2019 (COVID-19). The presented data proved that a systematic cognitive assessment (long-term and with appropriate instruments) of patients who had COVID-19 has to be an important element of the everyday clinical practice, as an early detection and interventions could improve solving problems associated with cogni- tive deficits after COVID-19 in the long term.
Key words COVID-19, profile of cognitive impairments, neurocognitive deficits, long-lasting consequences, cognitive screening
Access to full text version of the article pdf download
Bibliography
1. Xu K, Cai H, Shen Y, Ni Q, Chen Y, Hu S, Li J, Wang H, Yu L, Huang H, Qiu Y, Wei G, Fang Q, Zhou J, Sheng J, Liang T, Li L. [Management of COVID-19: the Zhejiang experience]. Zhejiang Da Xue Xue Bao Yi Xue Ban [J. Zhejiang. Univ. Med. Sci.]. 2020 Feb 21;49(2):147-157. doi: 10.3785/j.issn.1008-9292.2020.02.02. PMID: 32391658; PMCID: PMC8800711. (Chinese).
2. Al-Aly Z, Xie Y, Bowe B. High-dimensional characteri- zation of post-acute sequelae of COVID-19. Nature. 2021 Jun;594(7862):259-264. doi: 10.1038/s41586-021-03553-9. Epub 2021 Apr 22. PMID: 33887749.
3. Duan K, Premi E, Pilotto A, Cristillo V, Benussi A, Libri I, Giunta M, Bockholt HJ, Liu J, Campora R, Pezzini A, Gasparotti R, Magoni M, Padovani A, Calhoun VD. Alterations of frontal- temporal gray matter volume associate with clinical mea- sures of older adults with COVID-19. Neurobiol Stress. 2021 May;14:100326. doi: 10.1016/j.ynstr.2021.100326. Epub 2021 Apr 13. PMID: 33869679; PMCID: PMC8041745.
4. Liu, Y.-H., Wang, Y.-R., Wang, Q.-H., Chen, Y., Chen, X., Li, Y., Cen, Y., Xu, C., Hu, T., Liu, X.-D., Yang, L.-L., Li, S.-J., Liu, X.-F., Liu, C.-M., Zhu, J., Li, W., Zhang, L.-L., Liu, J., & Wang, Y.-J. (2021). Post-infection cognitive impairments in a cohort of elderly patients with COVID-19. Molecular Neurodegeneration, 16, Article 48. https://doi.org/10.1186/s13024-021-00469-w.
5. Tavares-Júnior JWL, de Souza ACC, Borges JWP, Oliveira DN, Siqueira-Neto JI, Sobreira-Neto MA, Braga-Neto P. COVID-19 associated cognitive impairment: A systematic review. Cortex. 2022 Jul;152:77-97. doi: 10.1016/j.cortex.2022.04.006. Epub 2022 Apr 18. PMID: 35537236; PMCID: PMC9014565.
6. Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, Walshaw C, Kemp S, Corrado J, Singh R, Collins T, O'Connor RJ, Sivan M. Postdischarge symptoms and rehabilita- tion needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021 Feb;93(2):1013-1022. doi: 10.1002/ jmv.26368. Epub 2020 Aug 17. PMID: 32729939.
7. Poletti S, Palladini M, Mazza MG, De Lorenzo R; COVID-19 BioB Outpatient Clinic Study group; Furlan R, Ciceri F, Rovere- Querini P, Benedetti F. Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life. Eur Arch Psychiatry Clin Neurosci. 2022 Aug;272(5):773-782. doi: 10.1007/s00406- 021-01346-9. Epub 2021 Oct 26. PMID: 34698871; PMCID: PMC8546751.
8. Almeria M, Cejudo JC, Sotoca J, Deus J, Krupinski J. Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment. Brain Behav Immun Health. 2020 Dec;9:100163. doi: 10.1016/j.bbih.2020.100163. Epub 2020 Oct 22. PMID: 33111132; PMCID: PMC7581383.
9. Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C, Fafi-Kremer S, Ohana M, Anheim M, Meziani F. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med. 2020 Jun 4;382(23):2268-2270. doi: 10.1056/NEJMc2008597. Epub 2020 Apr 15. PMID: 32294339; PMCID: PMC7179967.
10. Coleman B, Casiraghi E, Blau H, Chan L, Haendel MA, Laraway B, Callahan TJ, Deer RR, Wilkins KJ, Reese J, Robinson PN. Risk of new-onset psychiatric sequelae of COVID-19 in the early and late post-acute phase. World Psychiatry. 2022 Jun;21(2):319-320. doi: 10.1002/wps.20992. PMID: 35524622; PMCID: PMC9077621.
11. Ritchie K, Chan D. The emergence of cognitive COVID. World Psychiatry. 2021 Feb;20(1):52-53. doi: 10.1002/wps.20837. PMID: 33432769; PMCID: PMC7801840.
12. Heesakkers H, van der Hoeven JG, van den Boogaard M, Zegers M; MONITOR-IC research group. Two-year physical, mental and cognitive outcomes among intensive care unit survivors treated for COVID-19. Intensive Care Med. 2023 Apr 5:1–3. doi: 10.1007/s00134-023-07038-3. Epub ahead of print. PMID: 37017696; PMCID: PMC10073777.
13. Ferrucci R, Dini M, Rosci C, Capozza A, Groppo E, Reitano MR, Allocco E, Poletti B, Brugnera A, Bai F, Monti A, Ticozzi N, Silani V, Centanni S, D'Arminio Monforte A, Tagliabue L, Priori A. One-year cognitive follow-up of COVID-19 hospi- talized patients. Eur J Neurol. 2022 Jul;29(7):2006-2014. doi: 10.1111/ene.15324. Epub 2022 Mar 29. PMID: 35285122; PMCID: PMC9111730.
14. Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT. Cognitive impairment and altered cerebral glucose me- tabolism in the subacute stage of COVID-19. Brain. 2021 May 7;144(4):1263-1276. doi: 10.1093/brain/awab009. PMID: 33822001; PMCID: PMC8083602.
15. Yu AT, Absar NM. Long-term Neuropsychiatric Com pli- cations and 18F-FDG-PET Hypometabolism in the Brain From Prolonged Infection of COVID-19. Alzheimer Dis Assoc Disord. 2022 Apr-Jun 01;36(2):173-175. doi: 10.1097/WAD.0000000000000485. Epub 2021 Dec 30. PMID: 34966022; PMCID: PMC9132237.
16. Hugon J, Msika EF, Queneau M, Farid K, Paquet C. Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex. J Neurol. 2022 Jan;269(1):44-46. doi: 10.1007/ s00415-021-10655-x. Epub 2021 Jun 18. PMID: 34143277; PMCID: PMC8211714.
17. Shan D, Li S, Xu R, Nie G, Xie Y, Han J, Gao X, Zheng Y, Xu Z, Dai Z. Post-COVID-19 human memory impairment: A PRISMA- based systematic review of evidence from brain imaging stud- ies. Front Aging Neurosci. 2022 Dec 9;14:1077384. doi: 10.3389/ fnagi.2022.1077384. PMID: 36570532; PMCID: PMC9780393.
18. Jasti M, Nalleballe K, Dandu V, Onteddu S. A review of pathophysiology and neuropsychiatric manifestations of COVID-19. J Neurol. 2021 Jun;268(6):2007-2012. doi: 10.1007/ s00415-020-09950-w. Epub 2020 Jun 3. PMID: 32494854; PMCID: PMC7268182.
19. Crivelli L, Palmer K, Calandri I, Guekht A, Beghi E, Carroll W, Frontera J, García-Azorín D, Westenberg E, Winkler AS, Mangialasche F, Allegri RF, Kivipelto M. Changes in cognitive functioning after COVID-19: A systematic review and meta- analysis. Alzheimers Dement. 2022 May;18(5):1047-1066. doi: 10.1002/alz.12644. Epub 2022 Mar 17. PMID: 35297561; PMCID: PMC9073922.
20. Rogers JP, Chesney E, Oliver D, Pollak TA, McGuire P, Fusar-Poli P, Zandi MS, Lewis G, David AS. Psychiatric and neuropsychiatric presentations associated with severe coro- navirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry. 2020 Jul;7(7):611-627. doi: 10.1016/S2215-0366(20)30203-0. Epub 2020 May 18. PMID: 32437679; PMCID: PMC7234781.
21. Honarmand K, Lalli RS, Priestap F, Chen JL, McIntyre CW, Owen AM, Slessarev M. Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review. Am J Respir Crit Care Med. 2020 Jul 15;202(2):193-201. doi: 10.1164/rccm.201904- 0816CI. PMID: 32078780; PMCID: PMC7365360.
22. Geense, Wytske and Zegers, Marieke and Vermeulen, Hester and Boogaard, Mark and Hoeven, Johannes MONITOR- IC study, a mixed methods prospective multicentre controlled cohort study assessing 5-year outcomes of ICU survivors and related healthcare costs: a study protocol. BMJ Open. 2017. 7(11). e018006. doi: 10.1136/bmjopen-2017-018006.
23. Toniolo S, Di Lorenzo F, Scarioni M, Frederiksen KS, Nobili F. Is the Frontal Lobe the Primary Target of SARS-CoV-2? J Alzheimers Dis. 2021;81(1):75-81. doi: 10.3233/JAD-210008. PMID: 33720900.
24. Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, Guis S, Barthelemy F, Habert P, Ceccaldi M, Million M, Raoult D, Cammilleri S, Eldin C. 18F-FDG brain PET hypometabolism in patients with long COVID. Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2823-2833. doi: 10.1007/ s00259-021-05215-4. Epub 2021 Jan 26. PMID: 33501506; PMCID: PMC7837643.
25. Lu Y, Li X, Geng D, Mei N, Wu PY, Huang CC, Jia T, Zhao Y, Wang D, Xiao A, Yin B. Cerebral Micro-Structural Changes in COVID-19 Patients - An MRI-based 3-month Follow- up Study. EClinicalMedicine. 2020 Aug;25:100484. doi: 10.1016/j. eclinm.2020.100484. Epub 2020 Aug 3. PMID: 32838240; PMCID: PMC7396952.
 26. Blazhenets G, Schroeter N, Bormann T, Thurow J, Wagner D, Frings L, Weiller C, Meyer PT, Dressing A, Hosp JA. Slow but Evident Recovery from Neocortical Dysfunction and Cognitive Impairment in a Series of Chronic COVID-19 Patients. J Nucl Med. 2021 Jul 1;62(7):910-915. doi: 10.2967/ jnumed.121.262128. Epub 2021 Mar 31. PMID: 33789937; PMCID: PMC8882885.
27. Kas A, Soret M, Pyatigoskaya N, Habert MO, Hesters A, Le Guennec L, Paccoud O, Bombois S, Delorme C; on the behalf of CoCo-Neurosciences study group and COVID SMIT PSL study group. The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2543-2557. doi: 10.1007/s00259-020-05178-y. Epub 2021 Jan 15. Erratum in: Eur J Nucl Med Mol Imaging. 2022 Jul;49(9):3304. PMID: 33452633; PMCID: PMC7810428.
28. Alemanno F, Houdayer E, Parma A, Spina A, Del Forno A, Scatolini A, Angelone S, Brugliera L, Tettamanti A, Beretta L, Iannaccone S. COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience. PLoS One. 2021 Feb 8;16(2):e0246590. doi: 10.1371/ journal.pone.0246590. PMID: 33556127; PMCID: PMC7870071.
29. Jaywant A, Vanderlind WM, Alexopoulos GS, Fridman CB, Perlis RH, Gunning FM. Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19. Neuropsychopharmacology. 2021 Dec;46(13):2235- 2240. doi: 10.1038/s41386-021-00978-8. Epub 2021 Feb 15. PMID: 33589778; PMCID: PMC7884062.
30. Hellmuth J, Barnett TA, Asken BM, Kelly JD, Torres L, Stephens ML, Greenhouse B, Martin JN, Chow FC, Deeks SG, Greene M, Miller BL, Annan W, Henrich TJ, Peluso MJ. Persistent COVID-19-associated neurocognitive symptoms in non-hos- pitalized patients. J Neurovirol. 2021 Feb;27(1):191-195. doi: 10.1007/s13365-021-00954-4. Epub 2021 Feb 2. PMID: 33528824; PMCID: PMC7852463.
31. Negrini F, Ferrario I, Mazziotti D, Berchicci M, Bonazzi M, de Sire A, Negrini S, Zapparoli L. Neuropsychological Features of Severe Hospitalized Coronavirus Disease 2019 Patients at Clinical Stability and Clues for Postacute Rehabilitation. Arch Phys Med Rehabil. 2021 Jan;102(1):155-158. doi: 10.1016/j. apmr.2020.09.376. Epub 2020 Sep 28. PMID: 32991870; PMCID: PMC7521874.
32. Groiss SJ, Balloff C, Elben S, Brandenburger T, Müttel T, Kindgen-Milles D, Vollmer C, Feldt T, Kunstein A, Ole Jensen BE, Hartung HP, Schnitzler A, Albrecht P. Prolonged Neuropsychological Deficits, Central Ner vous System Involvement, and Brain Stem Affection After COVID-19-A Case Series. Front Neurol. 2020 Nov 5;11:574004. doi: 10.3389/ fneur.2020.574004. PMID: 33224088; PMCID: PMC7674620.
33. Beaud V, Crottaz-Herbette S, Dunet V, Vaucher J, Bernard- Valnet R, Du Pasquier R, Bart PA, Clarke S. Pattern of cognitive deficits in severe COVID-19. J Neurol Neurosurg Psychiatry. 2021 May;92(5):567-568. doi: 10.1136/jnnp-2020-325173. Epub 2020 Nov 20. PMID: 33219042; PMCID: PMC8053331.
34. Tolentino JC, Gjorup ALT, Schmidt GJ, Schmidt SL. Early attention impairment in a patient with COVID-19. Psychiatry Clin Neurosci. 2021 Feb;75(2):66-67. doi: 10.1111/pcn.13178. Epub 2020 Dec 14. PMID: 33241874; PMCID: PMC7753571.
35. Whiteside DM, Oleynick V, Holker E, Waldron EJ, Porter J, Kasprzak M. Neurocognitive deficits in severe COVID-19 infection: Case series and proposed model. Clin Neuropsychol. 2021 May;35(4):799-818. doi: 10.1080/13854046.2021.1874056. Epub 2021 Jan 25. PMID: 33487098.
36. Yesilkaya UH, Sen M, Balcioglu YH. COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway. J Clin Neurosci. 2021 May;87:153-155. doi: 10.1016/j.jocn.2021.03.007. Epub 2021 Mar 14. PMID: 33863524; PMCID: PMC7955917.
37. Henneghan AM, Lewis KA, Gill E, Kesler SR. Cognitive Impairment in Non-critical, Mild-to-Moderate COVID-19 Survivors. Front Psychol. 2022 Feb 17;13:770459. doi: 10.3389/ fpsyg.2022.770459. PMID: 35250714; PMCID: PMC8891805.
38. Graham EL, Clark JR, Orban ZS, Lim PH, Szymanski AL, Taylor C, DiBiase RM, Jia DT, Balabanov R, Ho SU, Batra A, Liotta EM, Koralnik IJ. Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 "long haulers". Ann Clin Transl Neurol. 2021 May;8(5):1073-1085. doi: 10.1002/acn3.51350. Epub 2021 Mar 30. PMID: 33755344; PMCID: PMC8108421.
39. Zhou H, Lu S, Chen J, Wei N, Wang D, Lyu H, Shi C, Hu S. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020 Oct;129:98-102. doi: 10.1016/j. jpsychires.2020.06.022. Epub 2020 Jun 30. PMID: 32912598; PMCID: PMC7324344.
40. Méndez R, Balanzá-Martínez V, Luperdi SC, Estrada I, Latorre A, González-Jiménez P, Feced L, Bouzas L, Yépez K, Ferrando A, Hervás D, Zaldívar E, Reyes S, Berk M, Menéndez R. Short-term neuropsychiatric outcomes and quality of life in COVID-19 survivors. J Intern Med. 2021 Sep;290(3):621-631. doi: 10.1111/joim.13262. Epub 2021 Mar 13. PMID: 33533521; PMCID: PMC8013333.
41. Mazza MG, Palladini M, De Lorenzo R, Magnaghi C, Poletti S, Furlan R, Ciceri F; COVID-19 BioB Outpatient Clinic Study group; Rovere-Querini P, Benedetti F. Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: Effect of inflammatory biomarkers at three-month follow- up. Brain Behav Immun. 2021 May;94:138-147. doi: 10.1016/j. bbi.2021.02.021. Epub 2021 Feb 24. PMID: 33639239; PMCID: PMC7903920.
42. Garrigues E, Janvier P, Kherabi Y, Le Bot A, Hamon A, Gouze H, Doucet L, Berkani S, Oliosi E, Mallart E, Corre F, Zarrouk V, Moyer JD, Galy A, Honsel V, Fantin B, Nguyen Y. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect. 2020 Dec; 81(6):e4-e6. doi: 10.1016/j.jinf.2020.08.029. Epub 2020 Aug 25. PMID: 32853602; PMCID: PMC7445491.
43. Bonizzato S, Ghiggia A, Ferraro F, Galante E. Cognitive, behavioral, and psychological manifestations of COVID-19 in post-acute rehabilitation setting: preliminary data of an observational study. Neurol Sci. 2022 Jan;43(1):51-58. doi: 10.1007/s10072-021-05653-w. Epub 2021 Oct 12. PMID: 34642823; PMCID: PMC8510572.
 44. Vannorsdall TD, Brigham E, Fawzy A, Raju S, Gorgone A, Pletnikova A, Lyketsos CG, Parker AM, Oh ES. Cognitive Dysfunction, Psychiatric Distress, and Functional Decline After COVID-19. J Acad Consult Liaison Psychiatry. 2022 Mar- Apr;63(2):133-143. doi: 10.1016/j.jaclp.2021.10.006. Epub 2021 Nov 15. PMID: 34793996; PMCID: PMC8591857.
45. Becker JH, Lin JJ, Doernberg M, Stone K, Navis A, Festa JR, Wisnivesky JP. Assessment of Cognitive Function in Patients After COVID-19 Infection. JAMA Netw Open. 2021 Oct 1;4(10):e2130645. doi: 10.1001/jamanetworkopen.2021.30645. PMID: 34677597; PMCID: PMC8536953.
46. Søraas A, Bø R, Kalleberg KT, Støer NC, Ellingjord-Dale M, Landrø NI. Self-reported Memory Problems 8 Months After COVID-19 Infection. JAMA Netw Open. 2021 Jul 1;4(7):e2118717. doi: 10.1001/jamanetworkopen.2021.18717. PMID: 34323987; PMCID: PMC8322992.
47. Ahmed M, Roy S, Iktidar MA, Chowdhury S, Akhter S, Khairul Islam AM, Hawlader MDH. Post-COVID-19 Memory Complaints: Prevalence and Associated Factors. Neurologia. 2022 Apr 20. doi: 10.1016/j.nrl.2022.03.007. Epub ahead of print. PMID: 35469238; PMCID: PMC9020525.
48. Li J, Yang Z, Qiu H, Wang Y, Jian L, Ji J, Li K. Anxiety and depression among general population in China at the peak of the COVID-19 epidemic. World Psychiatry. 2020 Jun;19(2):249-250. doi: 10.1002/wps.20758. PMID: 32394560; PMCID: PMC7214959.
49. Penninx BWJH. Psychiatric symptoms and cognitive impairment in "Long COVID": the relevance of immunopsy- chiatry. World Psychiatry. 2021 Oct;20(3):357-358. doi: 10.1002/ wps.20913. PMID: 34505378; PMCID: PMC8429338.
50. Miskowiak KW, Johnsen S, Sattler SM, Nielsen S, Kunalan K, Rungby J, Lapperre T, Porsberg CM. Cognitive impairments four months after COVID-19 hospital discharge: Pattern, severity and association with illness variables. Eur Neuropsychopharmacol. 2021 May;46:39-48. doi: 10.1016/j.euroneuro.2021.03.019. Epub 2021 Mar 29. PMID: 33823427; PMCID: PMC8006192.
51. Givens JL, Sanft TB, Marcantonio ER. Functional recovery after hip fracture: the combined effects of depressive symp- toms, cognitive impairment, and delirium. J Am Geriatr Soc. 2008 Jun;56(6):1075-9. doi: 10.1111/j.1532-5415.2008.01711.x. Epub 2008 Apr 18. PMID: 18422945.
52. Perrottelli A, Sansone N, Giordano GM, Caporusso E, Giuliani L, Melillo A, Pezzella P, Bucci P, Mucci A, Galderisi S. Cognitive Impairment after Post-Acute COVID-19 Infection: A Systematic Review of the Literature. J Pers Med. 2022 Dec 15;12(12):2070. doi: 10.3390/jpm12122070. PMID: 36556290; PMCID: PMC9781311.