ГоловнаArchive of numbers2023Volume 31, issue 1 (114)Clinical and genetic aspect of resistant depression in adolescents
Title of the article Clinical and genetic aspect of resistant depression in adolescents
Authors Mykhailova Iemiliia
Bahatska Nataliia
Mitelov Dmytro
Matkovska Tetiana
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL, MENTAL AND NARCOLOGICAL DISORDERS
Year 2023 Issue Volume 31, issue 1 (114) Pages 70-76
Type of article Scientific article Index UDK 616.89-008.454-053.6:159.922.73 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V31-is1-2023-10

 The work considers and distinguishes the psychopathological symptom complexes of depression in adolescents that are resistant to therapy: anxious, obsessive, behavioral. The level of spontaneous and induced mutagenesis in the blood lymphocytes of adolescents with depression was determined in vitro, which was twice the level of chromosomal aberrations after introducing a mutagen into the culture mixture, which indicates a pronounced individual and group hidden chromosomal instability of patients with depression. The constants of the lack of effectiveness of therapeutic intervention in adolescents with depression were determined (infantilism, personal anxiety, cogni- tive component of depression, noncompliance, addictions, comorbidity of depression with anorexia nervosa, suicidal behavior, recurrent depression, insufficient titration of antidepressant medication, unpleasant side effects of antidepressants).
Key words resistant depression, adolescents, chromosomal aberrations, risk factors
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