ГоловнаArchive of numbers2021Volume 29, issue 2 (107)Psychopathological consequences of COVID-19: possibilities of prevention and treatment
Title of the article Psychopathological consequences of COVID-19: possibilities of prevention and treatment
Authors Maruta Natalia
Fedchenko Viktoriya
In the section HELP TO PRACTICAL PHYSICIAN
Year 2021 Issue Volume 29, issue 2 (107) Pages 76-82
Type of article Scientific article Index UDK 616-036.21:371.711-08 Index BBK -
Abstract DOI: https://doi.org/10.36927/2079-0325-V29-is2-2021-13 During the COVID-19 pandemic, conditions for the deterioration of the mental health of a wide range of people at risk were created. The manifestation or exacerbation of mental illness contributes to the spread of COVID-19 and is associated with the frequent development of somatic complications and an unfavorable prognosis. Psychopharmacotherapy in patients with COVID-19 should take into account its effect on respiratory function, possible side effects and inter-drug interactions. The drug that can be recommended for the treatment of depressive and anxiety-depressive symptoms in COVID-19 is a representative of the modern class of antidepressants, multimodal modulators of the serotonin system — trazodone.
Key words coronavirus disease COVID-19, mental disorders, depressive disorders, therapy, trazodone coronavirus disease COVID-19, mental disorders, depressive disorders, therapy, trazodone
Access to full text version of the article pdf download
Bibliography 1. World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. http: //www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (Accessed on February 12, 2020). 2. Campion J, Javed A, Marmot M, Valsraj K . The need for a public mental health approach to COVID-19. World Social Psychiatry. 2020; 2: 77-83. DOI: 10.4103/WSP.WSP_48_20 3. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenburg N, Rubin GJ. The Psychological Impact of Quarantine and How to Reduce It: Rapid Review of the Evidence. The Lancet. 2020; 395: 912-920. DOI: https://doi.org/10.1016/S0140-6736(20)30460-8 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30460-8/fulltext 4. Wang C, Pan R, Wan X, Tan Y, Xu L, Ho CS, Ho RC. Int J Environ Res Public Health. 2020 Mar 6; 17(5): 1729. DOI: 10.3390/ijerph17051729. 5. Morens DM, Fauci AS. The 1918 influenza pandemic: insights for the 21st century. J. Infect. Dis. 2007; 195, 1018–1028. DOI: 10.1086/511989 6. Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J. Med. Virol. 2020; 92, 401–402. DOI: 10.1002/jmv.25678 7. Hui DS. et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J. Infect. Dis. 2020; 91: 264–266. DOI: 10.1016/j.ijid.2020.01.009 8. Gorbalenya AE et al. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat. Microbiol. 2020; 5, 536–544. 9. Ikeda K et al. The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology. J. Physiol. Sci. 2017; 67, 45–62. DOI: 10.1007/s12576-016-0475-y 10. Benarroch EE. Brainstem respiratory chemosensitivity: new insights and clinical implications. Neurology. 2007; 68, 2140–2143. DOI: https://doi.org/10.1212/01.wnl.0000266560.60371.98 11. Aziz, M., Aziz, M., Fatima, R., Assaly, R. Elevated interleukin‐6 and severe COVID‐19: a meta‐analysis. J. Med. Virol. https://doi.org/10.1002/jmv.259480. (2020). E-pub ahead of print. 12. Lindqvist, D. et al. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biol. Psychiatry. 2009; 66, 287–292. DOI: 10.1016/j.biopsych.2009.01.030 13. Sasayama, D. et al. Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder. J. Psychiatr. 2013; Res 47, 401–406. DOI: 10.1016/j.jpsychires.2012.12.001 14. Kern, S. et al. Higher CSF interleukin-6 and CSF interleukin-8 in current depression in older women. Results from a population-based sample. Brain Behav. Immun. 2014; 41, 55–58. DOI: 10.1016/j.bbi.2014.05.006 15. Castro VM, Perlis RH. Electronic Health Record Documentation of Psychiatric Assessments in Massachusetts Emergency Department and Outpatient Settings During the Coronavirus Disease 2019 (COVID-19) Pandemic. JAMA Netw Open. 2020; 3: e2011346. 16. Wilkinson E. How mental health services are adapting to provide care in the pandemic. BMJ 2020; 369: m2106. DOI: 10.1136/bmj.m2106 17. Xiang YT, Jin Y, Cheung T. Joint International Collaboration to Combat Mental Health Challenges During the Coronavirus Disease 2019 Pandemic. JAMA Psychiatry. 2020. DOI: 10.1001/jamapsychiatry.2020.1057 18. Shechter A, Diaz F, Moise N, et al. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry. 2020; 66: 1. DOI: 10.1016/j.genhosppsych. 2020.06.007 19. Lai J, Ma S, Wang Y, et al. Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. JAMA Netw Open. 2020; 3: e203976. DOI: 10.1001/jamanetworkopen.2020.3976 20. Rossi R, Socci V, Pacitti F, et al. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Netw Open. 2020; 3: e2010185. DOI: 10.1001/jamanetworkopen.2020.10185 21. Potloc and Canadian Public Health Association. Perception of Canadian health workers around the COVID-19 outbreak. https://potloc.com/blog/en/potloc-study-canadian-health-workers-insights-front-lines-covid-19-pandemic/ (Accessed on July 05, 2020). 22. Tan BYQ, Chew NWS, Lee GKH, et al. Psychological Impact of the COVID-19 Pandemic on Health Care Workers in Singapore. Ann Intern Med. 2020; 173: 317. DOI: 10.7326/M20-1083 23. Holmes EA, O'Connor RC, Perry VH, et al. Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry. 2020; 7: 547. DOI: https://doi.org/10.1016/S2215-0366(20)30168-1 24. Wang C, Pan R, Wan X, et al. Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Int J Environ Res Public Health. 2020; 17. DOI: 10.3390/ijerph17051729 25. Tang W, Hu T, Hu B, et al. Prevalence and correlates of PTSD and depressive symptoms one month after the outbreak of the COVID-19 epidemic in a sample of home-quarantined Chinese university students. J Affect Disord. 2020; 274: 1. DOI: 10.1016/j.jad.2020.05.009 26. Tian F, Li H, Tian S, et al. Psychological symptoms of ordinary Chinese citizens based on SCL-90 during the level I emergency response to COVID-19. Psychiatry Res. 2020; 288: 112992. DOI: 10.1016/j.psychres.2020.112992 27. American Psychiatric Association. New poll: COVID-19 impacting mental well-being: Americans feeling anxious, especially for loved ones; older adults are less anxious. Published March 25, 2020. https://www.psychiatry.org/newsroom/news-releases/new-poll-covid-19-impacting-mental-well-being-americans-feeling-anxious-especially-for-loved-ones-older-adults-are-less-anxious (Accessed on June 11, 2020). 28. McGinty EE, Presskreischer R, Han H, Barry CL. Psychological Distress and Loneliness Reported by US Adults in 2018 and April. 2020. JAMA 2020; 324: 93. DOI: 10.1001/jama.2020.9740 29. Pfefferbaum B, North CS. Mental Health and the Covid-19 Pandemic. N Engl J Med. 2020; 383: 510. DOI: 10.1056/NEJMp2008017 30. Reger MA, Stanley IH, Joiner TE. Suicide Mortality and Coronavirus Disease 2019-A Perfect Storm? JAMA Psychiatry. 2020; 77 (11): 1093-1094. DOI: 10.1001/jamapsychiatry.2020.1060 31. Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020; 395: 912. DOI: https://doi.org/10.1016/S0140-6736(20)30460-8 32. Galea S, Merchant RM, Lurie N. The Mental Health Consequences of COVID-19 and Physical Distancing: The Need for Prevention and Early Intervention. JAMA Intern Med. 2020; 180: 817. DOI: 10.1001/jamainternmed.2020.1562 33. Zhou J, Liu L, Xue P, et al. Mental Health Response to the COVID-19 Outbreak in China. Am J Psychiatry. 2020; 177: 574. DOI: 10.1176/appi.ajp.2020.20030304 34. Rogers JP, Chesney E, Oliver D, et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry. 2020; 7: 611. DOI: https://doi.org/10.1016/S2215-0366(20)30203-0 35. Kisely S, Warren N, McMahon L, et al. Occurrence, prevention, and management of the psychological effects of emerging virus outbreaks on healthcare workers: rapid review and meta-analysis. BMJ 2020; 369: m1642. DOI: 10.1136/bmj.m1642 36. Sommer IE, Bakker PR. What can psychiatrists learn from SARS and MERS outbreaks? Lancet Psychiatry. 2020; 7: 565. DOI: 10.1016/S2215-0366(20)30219-4 37. Stam HJ, Stucki G, Bickenbach J. Covid-19 and Post Intensive Care Syndrome: A Call for Action. J Rehabil Med. 2020; 52: jrm00044. DOI: 10.2340/16501977-2677 38. Nikayin S, Rabiee A, Hashem MD, et al. Anxiety symptoms in survivors of critical illness: a systematic review and meta-analysis. Gen Hosp Psychiatry. 2016; 43: 23. DOI: 10.1016/j.genhosppsych.2016.08.005 39. Rabiee A, Nikayin S, Hashem MD, et al. Depressive Symptoms After Critical Illness: A Systematic Review and Meta-Analysis. Crit Care Med. 2016; 44: 1744. DOI: 10.1097/CCM.0000000000001811 40. Parker AM, Sricharoenchai T, Raparla S, et al. Posttraumatic stress disorder in critical illness survivors: a metaanalysis. Crit Care Med. 2015; 43: 1121. DOI: 10.1097/CCM.0000000000000882 41. Hatch R, Young D, Barber V, et al. Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study. Crit Care. 2018; 22: 310. DOI: 10.1186/s13054-018-2223-6 42. Cohen GH, Tamrakar S, Lowe S, et al. Comparison of Simulated Treatment and Cost-effectiveness of a Stepped Care Case-Finding Intervention vs Usual Care for Posttraumatic Stress Disorder After a Natural Disaster. JAMA Psychiatry. 2017; 74: 1251. DOI: 10.1001/jamapsychiatry.2017.3037 43. Razai MS, Oakeshott P, Kankam H, et al. Mitigating the psychological effects of social isolation during the covid-19 pandemic. BMJ. 2020; 369: m1904. DOI: https://doi.org/10.1136/bmj.m1904 44. Zhang K, Zhou X, Liu H, Hashimoto K. Treatment concerns for psychiatric symptoms in patients with COVID-19 with or without psychiatric disorders. Br J Psychiatry. 2020; 217: 351. DOI: 10.1192/bjp.2020.84 45. M, Kasper S. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012; 26: 1033-49. DOI: 10.1007/s40263-012-0010-5 46. Stahl SM. Mechanism of action of trazodone: a multifunctional drug. CNS Spectr. 2009; 14: 536-46. DOI: 10.1017/s1092852900024020 47. Karhu D, Groenewoud G, Potgieter MA, Mould DR. Dose proportionality of once-daily trazodone extended-release caplets under fasting conditions. J Clin Pharmacol. 2010; 50: 1438-49. DOI: 10.1177/0091270009360979 48 Frecska E. Trazodone – it’s multifunctional mechanism of action and clinical use. Neuropsychofarmacol Hung. 2010; 12: 477-82. 49. Smulevich A. B. Depressii pri somaticheskikh i psikhicheskikh zabolevaniyakh [Depression in somatic and mental diseases]. M.: Mediczinskoe informaczionnoe agentstvo; 2003: 209 s. 50. Busner J. The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont). 2007; 4 (7): 28–37.